(62 nodes) DNA replication network (Erinaceus europaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSEEUP00000011081	annotation not available (427 aa)
	ENSEEUP00000011149	annotation not available (85 aa)
	POLE3	DNA polymerase epsilon subunit 3. (147 aa)
	C16orf70	UPF0183 protein C16orf70 homolog. (400 aa)
	ATAD5	ATPase family AAA domain containing 5. (1813 aa)
	RFC5	Replication factor C subunit 5. (304 aa)
	SASS6	Spindle assembly abnormal protein 6 homolog. (655 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (516 aa)
	MEIOB	Meiosis-specific with OB domain-containing protein. (214 aa)
	MCM2	DNA helicase; Belongs to the MCM family. (536 aa)
	LIG1	DNA ligase 1. (919 aa)
	MCM3	DNA helicase; Belongs to the MCM family. (788 aa)
	CPNE4	Copine-4. (496 aa)
	GEN1	Flap endonuclease GEN homolog 1. (871 aa)
	MACROD2	mono-ADP ribosylhydrolase 2. (422 aa)
	MCMDC2	MCM domain-containing protein 2 isoform X2. (590 aa)
	GTF3C6	LOW QUALITY PROTEIN: general transcription factor 3C polypeptide 6-like. (219 aa)
	CPNE2	Copine-2. (548 aa)
	ENSEEUP00000002862	annotation not available (684 aa)
	PCNA	Proliferating cell nuclear antigen. (259 aa)
	TOR1A	Torsin. (333 aa)
	MCM6	DNA helicase; Belongs to the MCM family. (820 aa)
	ENSEEUP00000002125	annotation not available (198 aa)
	ENSEEUP00000002093	annotation not available (1887 aa)
	STN1	STN1 subunit of CST complex. (369 aa)
	PRIM2	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (452 aa)
	ENSEEUP00000002022	annotation not available (356 aa)
	GDAP2	Ganglioside-induced differentiation-associated protein 2. (433 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	PARP14	Poly [ADP-ribose] polymerase. (1634 aa)
	TOR3A	torsin-3A. (381 aa)
	FAM162A	Protein FAM162A. (186 aa)
	ENSEEUP00000001422	annotation not available (445 aa)
	ENSEEUP00000000307	annotation not available (84 aa)
	ENSEEUP00000000369	annotation not available (121 aa)
	ENSEEUP00000004683	annotation not available (557 aa)
	ENSEEUP00000004885	annotation not available (315 aa)
	PARP9	Poly [ADP-ribose] polymerase 9. (715 aa)
	ENSEEUP00000005701	annotation not available (1146 aa)
	POLD2	DNA polymerase delta subunit 2. (466 aa)
	RNASEH2B	Ribonuclease H2 subunit B isoform X2. (303 aa)
	TOR1B	Torsin family 1 member B. (335 aa)
	MCM7	Minichromosome maintenance complex component 7. (682 aa)
	CPNE3	Copine-3. (537 aa)
	RNASEH2A	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (294 aa)
	YJU2	YJU2 splicing factor homolog. (231 aa)
	MCM4	DNA helicase; Belongs to the MCM family. (829 aa)
	ENSEEUP00000007707	annotation not available (128 aa)
	PRKRIP1	PRKR-interacting protein 1. (153 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	DNA2	DNA replication ATP-dependent helicase/nuclease DNA2. (924 aa)
	POLD3	DNA polymerase delta subunit 3. (404 aa)
	RFC3	Replication factor C subunit 3. (353 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (95 aa)
	POLE4	DNA polymerase epsilon subunit 4. (97 aa)
	CPNE5	Copine-5 isoform X2. (593 aa)
	POLA1	DNA polymerase alpha 1, catalytic subunit. (1463 aa)
	ENSEEUP00000009711	annotation not available (333 aa)
	SSBP1	Single-stranded DNA-binding protein, mitochondrial. (147 aa)
	ENSEEUP00000010189	annotation not available (368 aa)
	PARP15	Poly [ADP-ribose] polymerase. (495 aa)
	WRNIP1	ATPase WRNIP1 isoform X1. (533 aa)

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	B2M	ENSEEUP00000011589	ENSEEUP00000008754	ATPase family AAA domain containing 5.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.598
ATAD5	DNA2	ENSEEUP00000011589	ENSEEUP00000008021	ATPase family AAA domain containing 5.	DNA replication ATP-dependent helicase/nuclease DNA2.	0.890
ATAD5	ENSEEUP00000000307	ENSEEUP00000011589	ENSEEUP00000000307	ATPase family AAA domain containing 5.	annotation not available	0.598
ATAD5	ENSEEUP00000000369	ENSEEUP00000011589	ENSEEUP00000000369	ATPase family AAA domain containing 5.	annotation not available	0.694
ATAD5	ENSEEUP00000002022	ENSEEUP00000011589	ENSEEUP00000002022	ATPase family AAA domain containing 5.	annotation not available	0.622
ATAD5	ENSEEUP00000002093	ENSEEUP00000011589	ENSEEUP00000002093	ATPase family AAA domain containing 5.	annotation not available	0.867
ATAD5	ENSEEUP00000002862	ENSEEUP00000011589	ENSEEUP00000002862	ATPase family AAA domain containing 5.	annotation not available	0.945
ATAD5	ENSEEUP00000004885	ENSEEUP00000011589	ENSEEUP00000004885	ATPase family AAA domain containing 5.	annotation not available	0.988
ATAD5	ENSEEUP00000005701	ENSEEUP00000011589	ENSEEUP00000005701	ATPase family AAA domain containing 5.	annotation not available	0.544
ATAD5	ENSEEUP00000009711	ENSEEUP00000011589	ENSEEUP00000009711	ATPase family AAA domain containing 5.	annotation not available	0.598
ATAD5	ENSEEUP00000011081	ENSEEUP00000011589	ENSEEUP00000011081	ATPase family AAA domain containing 5.	annotation not available	0.831
ATAD5	GEN1	ENSEEUP00000011589	ENSEEUP00000004437	ATPase family AAA domain containing 5.	Flap endonuclease GEN homolog 1.	0.754
ATAD5	LIG1	ENSEEUP00000011589	ENSEEUP00000014075	ATPase family AAA domain containing 5.	DNA ligase 1.	0.841
ATAD5	MCM2	ENSEEUP00000011589	ENSEEUP00000013501	ATPase family AAA domain containing 5.	DNA helicase; Belongs to the MCM family.	0.890
ATAD5	MCM3	ENSEEUP00000011589	ENSEEUP00000004609	ATPase family AAA domain containing 5.	DNA helicase; Belongs to the MCM family.	0.446
ATAD5	MCM4	ENSEEUP00000011589	ENSEEUP00000007638	ATPase family AAA domain containing 5.	DNA helicase; Belongs to the MCM family.	0.772
ATAD5	MCM6	ENSEEUP00000011589	ENSEEUP00000002647	ATPase family AAA domain containing 5.	DNA helicase; Belongs to the MCM family.	0.681
ATAD5	MCM7	ENSEEUP00000011589	ENSEEUP00000007000	ATPase family AAA domain containing 5.	Minichromosome maintenance complex component 7.	0.706
ATAD5	MEIOB	ENSEEUP00000011589	ENSEEUP00000013330	ATPase family AAA domain containing 5.	Meiosis-specific with OB domain-containing protein.	0.817
ATAD5	PCNA	ENSEEUP00000011589	ENSEEUP00000002812	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen.	0.977