(57 nodes) Nucleotide excision repair network (Erinaceus europaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	POLD2	DNA polymerase delta subunit 2. (466 aa)
	LIG1	DNA ligase 1. (919 aa)
	XPC	DNA repair protein complementing XP-C cells. (912 aa)
	CDK20	Cyclin-dependent kinase 20 isoform X4; Belongs to the protein kinase superfamily. (235 aa)
	MEIOB	Meiosis-specific with OB domain-containing protein. (214 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (516 aa)
	ENSEEUP00000012754	annotation not available (247 aa)
	SASS6	Spindle assembly abnormal protein 6 homolog. (655 aa)
	CUL4B	cullin-4B isoform X1; Belongs to the cullin family. (893 aa)
	CDK7	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (246 aa)
	RFC5	Replication factor C subunit 5. (304 aa)
	ERCC1	DNA excision repair protein ERCC-1 isoform X2. (232 aa)
	ATAD5	ATPase family AAA domain containing 5. (1813 aa)
	POLE3	DNA polymerase epsilon subunit 3. (147 aa)
	GTF2H1	General transcription factor IIH subunit 1 isoform X1. (424 aa)
	WDR76	WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (604 aa)
	ENSEEUP00000011189	annotation not available (1002 aa)
	ENSEEUP00000010992	annotation not available (59 aa)
	DDX11	Probable ATP-dependent DNA helicase DDX11. (801 aa)
	ZNF608	Zinc finger protein 608 isoform X1. (1371 aa)
	LOC103116283	General transcription factor IIH subunit 3-like isoform X2. (217 aa)
	ENSEEUP00000009711	annotation not available (333 aa)
	ERCC2	TFIIH basal transcription factor complex helicase XPD subunit. (729 aa)
	POLE4	DNA polymerase epsilon subunit 4. (97 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (95 aa)
	ENSEEUP00000008599	annotation not available (323 aa)
	GTF2H3	General transcription factor IIH subunit 3. (304 aa)
	RFC3	Replication factor C subunit 3. (353 aa)
	POLD3	DNA polymerase delta subunit 3. (404 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	PRKRIP1	PRKR-interacting protein 1. (153 aa)
	ERCC6	DNA excision repair protein ERCC-6. (1468 aa)
	ENSEEUP00000007707	annotation not available (128 aa)
	YJU2	YJU2 splicing factor homolog. (231 aa)
	ENSEEUP00000000307	annotation not available (84 aa)
	ENSEEUP00000000369	annotation not available (121 aa)
	FBH1	F-box DNA helicase 1 isoform X1. (977 aa)
	ERCC3	TFIIH basal transcription factor complex helicase XPB subunit isoform X1. (733 aa)
	MNAT1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (269 aa)
	RAD23B	UV excision repair protein RAD23 homolog B. (360 aa)
	ENSEEUP00000001618	annotation not available (457 aa)
	GTF2H5	General transcription factor IIH subunit 5. (71 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	ENSEEUP00000002022	annotation not available (356 aa)
	STN1	STN1 subunit of CST complex. (369 aa)
	ENSEEUP00000002093	annotation not available (1887 aa)
	PCNA	Proliferating cell nuclear antigen. (259 aa)
	DDB1	DNA damage-binding protein 1. (1138 aa)
	ENSEEUP00000002984	annotation not available (425 aa)
	GTF3C6	LOW QUALITY PROTEIN: general transcription factor 3C polypeptide 6-like. (219 aa)
	ERCC8	DNA excision repair protein ERCC-8. (395 aa)
	CLSPN	Claspin. (1328 aa)
	ENSEEUP00000004885	annotation not available (315 aa)
	ENSEEUP00000004944	annotation not available (389 aa)
	XPA	DNA repair protein complementing XP-A cells. (214 aa)
	ENSEEUP00000005701	annotation not available (1146 aa)
	ERCC4	DNA repair endonuclease XPF. (918 aa)

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	B2M	ENSEEUP00000011589	ENSEEUP00000008754	ATPase family AAA domain containing 5.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.598
ATAD5	CLSPN	ENSEEUP00000011589	ENSEEUP00000004857	ATPase family AAA domain containing 5.	Claspin.	0.858
ATAD5	CUL4B	ENSEEUP00000011589	ENSEEUP00000012607	ATPase family AAA domain containing 5.	cullin-4B isoform X1; Belongs to the cullin family.	0.636
ATAD5	DDX11	ENSEEUP00000011589	ENSEEUP00000010841	ATPase family AAA domain containing 5.	Probable ATP-dependent DNA helicase DDX11.	0.792
ATAD5	ENSEEUP00000000307	ENSEEUP00000011589	ENSEEUP00000000307	ATPase family AAA domain containing 5.	annotation not available	0.598
ATAD5	ENSEEUP00000000369	ENSEEUP00000011589	ENSEEUP00000000369	ATPase family AAA domain containing 5.	annotation not available	0.694
ATAD5	ENSEEUP00000002022	ENSEEUP00000011589	ENSEEUP00000002022	ATPase family AAA domain containing 5.	annotation not available	0.622
ATAD5	ENSEEUP00000002093	ENSEEUP00000011589	ENSEEUP00000002093	ATPase family AAA domain containing 5.	annotation not available	0.867
ATAD5	ENSEEUP00000002984	ENSEEUP00000011589	ENSEEUP00000002984	ATPase family AAA domain containing 5.	annotation not available	0.406
ATAD5	ENSEEUP00000004885	ENSEEUP00000011589	ENSEEUP00000004885	ATPase family AAA domain containing 5.	annotation not available	0.988
ATAD5	ENSEEUP00000004944	ENSEEUP00000011589	ENSEEUP00000004944	ATPase family AAA domain containing 5.	annotation not available	0.754
ATAD5	ENSEEUP00000005701	ENSEEUP00000011589	ENSEEUP00000005701	ATPase family AAA domain containing 5.	annotation not available	0.544
ATAD5	ENSEEUP00000009711	ENSEEUP00000011589	ENSEEUP00000009711	ATPase family AAA domain containing 5.	annotation not available	0.598
ATAD5	ENSEEUP00000011189	ENSEEUP00000011589	ENSEEUP00000011189	ATPase family AAA domain containing 5.	annotation not available	0.754
ATAD5	ENSEEUP00000012754	ENSEEUP00000011589	ENSEEUP00000012754	ATPase family AAA domain containing 5.	annotation not available	0.441
ATAD5	ERCC2	ENSEEUP00000011589	ENSEEUP00000009661	ATPase family AAA domain containing 5.	TFIIH basal transcription factor complex helicase XPD subunit.	0.640
ATAD5	ERCC4	ENSEEUP00000011589	ENSEEUP00000007144	ATPase family AAA domain containing 5.	DNA repair endonuclease XPF.	0.694
ATAD5	ERCC8	ENSEEUP00000011589	ENSEEUP00000004017	ATPase family AAA domain containing 5.	DNA excision repair protein ERCC-8.	0.454
ATAD5	FBH1	ENSEEUP00000011589	ENSEEUP00000000409	ATPase family AAA domain containing 5.	F-box DNA helicase 1 isoform X1.	0.671
ATAD5	GTF2H1	ENSEEUP00000011589	ENSEEUP00000011507	ATPase family AAA domain containing 5.	General transcription factor IIH subunit 1 isoform X1.	0.577