STRINGSTRING
HDAC2 HDAC2 CDC23 CDC23 CDC45 CDC45 CDK4 CDK4 CDC26 CDC26 STAG2 STAG2 MCM7 MCM7 SMAD2 SMAD2 PRKDC PRKDC CDK1 CDK1 ORC5 ORC5 CDKN2B CDKN2B ENSEEUP00000010564 ENSEEUP00000010564 TMEM82 TMEM82 CDC14A CDC14A ATM ATM CDKN2D CDKN2D CDC25A CDC25A MCM4 MCM4 ZNF652 ZNF652 RBL2 RBL2 GSK3B GSK3B ANAPC4 ANAPC4 CDC27 CDC27 CDC7 CDC7 AP5S1 AP5S1 ENSEEUP00000008599 ENSEEUP00000008599 EP300 EP300 ORC2 ORC2 MAD2L1 MAD2L1 RBL1 RBL1 YWHAG YWHAG CCNB1 CCNB1 DBF4 DBF4 TGFB1 TGFB1 MCM3 MCM3 ENSEEUP00000004580 ENSEEUP00000004580 ZBTB46 ZBTB46 ENSEEUP00000004369 ENSEEUP00000004369 MYNN MYNN CCND3 CCND3 CHEK1 CHEK1 ORC3 ORC3 PCNA PCNA MCM6 MCM6 ENSEEUP00000002529 ENSEEUP00000002529 CDC25C CDC25C ENSEEUP00000002216 ENSEEUP00000002216 CCNE2 CCNE2 ENSEEUP00000001618 ENSEEUP00000001618 ABL1 ABL1 CCNA1 CCNA1 ENSEEUP00000000492 ENSEEUP00000000492 SMAD4 SMAD4 SKP2 SKP2 ENSEEUP00000001332 ENSEEUP00000001332 MYC MYC RAD21 RAD21 ENSEEUP00000001281 ENSEEUP00000001281 ENSEEUP00000001196 ENSEEUP00000001196 CDKN2C CDKN2C ENSEEUP00000001146 ENSEEUP00000001146 ORC4 ORC4 CCNB2 CCNB2 ANAPC10 ANAPC10 ESPL1 ESPL1 ANAPC2 ANAPC2 ENSEEUP00000000751 ENSEEUP00000000751 STAG1 STAG1 ENSEEUP00000010893 ENSEEUP00000010893 TGFB2 TGFB2 SMC1B SMC1B ATR ATR CDKN1A CDKN1A CDK3 CDK3 ORC6 ORC6 ORC1 ORC1 ZBTB10 ZBTB10 CDC25B CDC25B ENSEEUP00000011702 ENSEEUP00000011702 ENSEEUP00000011815 ENSEEUP00000011815 SNAPIN SNAPIN PTTG1 PTTG1 E2F2 E2F2 GADD45G GADD45G BUB1B BUB1B CDK7 CDK7 CCNA2 CCNA2 TTK TTK CDKN1B CDKN1B SKP1 SKP1 CDK6 CDK6 CDK2 CDK2 E2F4 E2F4 PKMYT1 PKMYT1 E2F5 E2F5 TP53 TP53 FAM126B FAM126B ENSEEUP00000013426 ENSEEUP00000013426 CDK20 CDK20 MCM2 MCM2 HDAC3 HDAC3 ENSEEUP00000013640 ENSEEUP00000013640 ENSEEUP00000014174 ENSEEUP00000014174 CDC6 CDC6 ENSEEUP00000014410 ENSEEUP00000014410 CDC20 CDC20 E2F1 E2F1 SMC3 SMC3 BUB1 BUB1 E2F3 E2F3 WEE1 WEE1 CDC20B CDC20B RB1 RB1 CREBBP CREBBP CCNE1 CCNE1 YWHAQ YWHAQ ENSEEUP00000005302 ENSEEUP00000005302 ENSEEUP00000005308 ENSEEUP00000005308 ENSEEUP00000005358 ENSEEUP00000005358 ENSEEUP00000005380 ENSEEUP00000005380 MAD2L2 MAD2L2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (470 aa)
CDC23Cell division cycle 23. (591 aa)
CDC45Cell division control protein 45 homolog. (481 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CDC26Anaphase-promoting complex subunit CDC26. (58 aa)
STAG2Cohesin subunit SA-2. (1268 aa)
MCM7Minichromosome maintenance complex component 7. (682 aa)
SMAD2Mothers against decapentaplegic homolog. (426 aa)
PRKDCDNA-dependent protein kinase catalytic subunit. (4126 aa)
CDK1Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. (284 aa)
ORC5Origin recognition complex subunit 5. (420 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (138 aa)
ENSEEUP00000010564annotation not available (560 aa)
TMEM82Transmembrane protein 82. (305 aa)
CDC14ADual specificity protein phosphatase CDC14A. (579 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3041 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (121 aa)
CDC25AM-phase inducer phosphatase 1. (509 aa)
MCM4DNA helicase; Belongs to the MCM family. (829 aa)
ZNF652Zinc finger protein 652. (608 aa)
RBL2Retinoblastoma-like protein 2 isoform X2. (1136 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X2; Belongs to the protein kinase superfamily. (433 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa)
CDC27Cell division cycle protein 27 homolog. (785 aa)
CDC7Cell division cycle 7-related protein kinase. (483 aa)
AP5S1AP-5 complex subunit sigma-1. (141 aa)
ENSEEUP00000008599annotation not available (323 aa)
EP300Histone acetyltransferase p300. (1983 aa)
ORC2Origin recognition complex subunit 2. (548 aa)
MAD2L1Mitotic spindle assembly checkpoint protein MAD2A. (196 aa)
RBL1Retinoblastoma-like protein 1. (876 aa)
YWHAG14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (394 aa)
DBF4Protein DBF4 homolog A. (514 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MCM3DNA helicase; Belongs to the MCM family. (788 aa)
ENSEEUP00000004580annotation not available (624 aa)
ZBTB46Zinc finger and BTB domain-containing protein 46. (405 aa)
ENSEEUP00000004369annotation not available (1233 aa)
MYNNMyoneurin. (519 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (226 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (476 aa)
ORC3Origin recognition complex subunit 3. (712 aa)
PCNAProliferating cell nuclear antigen. (259 aa)
MCM6DNA helicase; Belongs to the MCM family. (820 aa)
ENSEEUP00000002529annotation not available (468 aa)
CDC25CM-phase inducer phosphatase 3 isoform X2. (418 aa)
ENSEEUP00000002216annotation not available (543 aa)
CCNE2G1/S-specific cyclin-E2 isoform X2; Belongs to the cyclin family. (403 aa)
ENSEEUP00000001618annotation not available (457 aa)
ABL1Tyrosine-protein kinase. (925 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (413 aa)
ENSEEUP00000000492annotation not available (46 aa)
SMAD4Mothers against decapentaplegic homolog. (551 aa)
SKP2S-phase kinase-associated protein 2 isoform X2. (314 aa)
ENSEEUP00000001332annotation not available (113 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
RAD21Double-strand-break repair protein rad21 homolog. (631 aa)
ENSEEUP00000001281annotation not available (392 aa)
ENSEEUP00000001196annotation not available (240 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
ENSEEUP00000001146annotation not available (493 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (362 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (123 aa)
ESPL1Separin. (2102 aa)
ANAPC2Anaphase promoting complex subunit 2. (818 aa)
ENSEEUP00000000751annotation not available (1259 aa)
STAG1Cohesin subunit SA-1 isoform X1. (1257 aa)
ENSEEUP00000010893annotation not available (47 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
SMC1BStructural maintenance of chromosomes protein 1B. (1204 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2572 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (159 aa)
CDK3Cyclin-dependent kinase 3 isoform X1; Belongs to the protein kinase superfamily. (304 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (797 aa)
ZBTB10Zinc finger and BTB domain-containing protein 10 isoform X2. (776 aa)
CDC25BM-phase inducer phosphatase 2 isoform X1. (601 aa)
ENSEEUP00000011702annotation not available (224 aa)
ENSEEUP00000011815annotation not available (1943 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (133 aa)
PTTG1Securin isoform X1. (201 aa)
E2F2Transcription factor E2F2. (431 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (94 aa)
BUB1BMitotic checkpoint serine/threonine-protein kinase BUB1 beta. (1043 aa)
CDK7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (246 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (256 aa)
TTKDual specificity protein kinase TTK. (772 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (197 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (47 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
E2F4Transcription factor E2F4 isoform X1. (409 aa)
PKMYT1Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1; Belongs to the protein kinase superfamily. (493 aa)
E2F5Transcription factor E2F5. (269 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
FAM126BProtein FAM126B isoform X2. (525 aa)
ENSEEUP00000013426annotation not available (47 aa)
CDK20Cyclin-dependent kinase 20 isoform X4; Belongs to the protein kinase superfamily. (235 aa)
MCM2DNA helicase; Belongs to the MCM family. (536 aa)
HDAC3Histone deacetylase 3 isoform X2. (353 aa)
ENSEEUP00000013640annotation not available (750 aa)
ENSEEUP00000014174annotation not available (150 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (553 aa)
ENSEEUP00000014410annotation not available (414 aa)
CDC20Cell division cycle protein 20 homolog. (500 aa)
E2F1Transcription factor E2F1. (341 aa)
SMC3Structural maintenance of chromosomes protein 3. (1219 aa)
BUB1Mitotic checkpoint serine/threonine-protein kinase BUB1. (1068 aa)
E2F3Transcription factor E2F3 isoform X1. (461 aa)
WEE1Wee1-like protein kinase. (380 aa)
CDC20BCell division cycle protein 20 homolog B. (484 aa)
RB1Retinoblastoma-associated protein. (928 aa)
CREBBPCREB-binding protein. (2360 aa)
CCNE1LOW QUALITY PROTEIN: G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (178 aa)
ENSEEUP00000005302annotation not available (113 aa)
ENSEEUP00000005308annotation not available (706 aa)
ENSEEUP00000005358annotation not available (228 aa)
ENSEEUP00000005380annotation not available (91 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (216 aa)
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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