STRINGSTRING
VDAC3 VDAC3 RBL1 RBL1 ENSEEUP00000008767 ENSEEUP00000008767 MAPK14 MAPK14 HIPK1 HIPK1 ENSEEUP00000008412 ENSEEUP00000008412 FOXM1 FOXM1 EFCAB3 EFCAB3 TGFBR2 TGFBR2 PTEN PTEN VDAC2 VDAC2 RHEBL1 RHEBL1 MRE11 MRE11 RBL2 RBL2 PIK3CB PIK3CB CDC25A CDC25A RAD1 RAD1 IGFBP3 IGFBP3 ENSEEUP00000007255 ENSEEUP00000007255 ATM ATM MYBL2 MYBL2 CDK1 CDK1 MRAS MRAS SMAD2 SMAD2 ENSEEUP00000006766 ENSEEUP00000006766 NFATC3 NFATC3 LIN9 LIN9 LOC103117188 LOC103117188 NFATC1 NFATC1 PPP3CC PPP3CC CDK4 CDK4 ENSEEUP00000005984 ENSEEUP00000005984 ENSEEUP00000005868 ENSEEUP00000005868 CSDE1 CSDE1 ITPR3 ITPR3 TPRG1 TPRG1 MAPK13 MAPK13 RASSF3 RASSF3 CDK3 CDK3 CDKN1A CDKN1A ATR ATR TGFB2 TGFB2 CDKN2B CDKN2B LIN52 LIN52 TRAF3IP2 TRAF3IP2 LIN37 LIN37 RAF1 RAF1 NFATC4 NFATC4 AKT1 AKT1 CAPN11 CAPN11 TRPM7 TRPM7 TGFBR1 TGFBR1 TPRG1L TPRG1L ENSEEUP00000012010 ENSEEUP00000012010 AKT2 AKT2 SIRT1 SIRT1 E2F2 E2F2 LOC103126273 LOC103126273 GADD45G GADD45G LOC103128309 LOC103128309 CCNA2 CCNA2 CDK6 CDK6 IL1A IL1A PPID PPID CDK2 CDK2 E2F4 E2F4 FOXO3 FOXO3 E2F5 E2F5 HRAS HRAS TP53 TP53 ENSEEUP00000013398 ENSEEUP00000013398 ITPR2 ITPR2 HIPK4 HIPK4 PIK3CA PIK3CA BTRC BTRC ENSEEUP00000013950 ENSEEUP00000013950 HIPK3 HIPK3 GATA4 GATA4 ENSEEUP00000014174 ENSEEUP00000014174 CAPN8 CAPN8 PPID-2 PPID-2 SQSTM1 SQSTM1 NBN NBN RB1 RB1 CALM3 CALM3 RRAS2 RRAS2 ENSEEUP00000000381 ENSEEUP00000000381 CCNE1 CCNE1 MAPKAPK2 MAPKAPK2 RAD50 RAD50 SLC25A5 SLC25A5 ENSEEUP00000000720 ENSEEUP00000000720 ENSEEUP00000000751 ENSEEUP00000000751 CCDC109B CCDC109B SLC25A4 SLC25A4 CCNB2 CCNB2 ENSEEUP00000001051 ENSEEUP00000001051 MYC MYC CCNA1 CCNA1 LOC103127729 LOC103127729 ENSEEUP00000001616 ENSEEUP00000001616 TSC2 TSC2 LIN54 LIN54 MCU MCU CCNE2 CCNE2 ENSEEUP00000002216 ENSEEUP00000002216 SLC25A6 SLC25A6 PIK3R3 PIK3R3 MAPK1 MAPK1 CALM2 CALM2 ETS1 ETS1 RBBP4 RBBP4 KRAS KRAS ENSEEUP00000002875 ENSEEUP00000002875 LOC103127736 LOC103127736 PPP1CC PPP1CC CHEK1 CHEK1 ENSEEUP00000003494 ENSEEUP00000003494 CCND3 CCND3 CAPN12 CAPN12 TSC1 TSC1 PPP3R2 PPP3R2 GATA5 GATA5 ENSEEUP00000004263 ENSEEUP00000004263 ENSEEUP00000004392 ENSEEUP00000004392 ENSEEUP00000004408 ENSEEUP00000004408 ENSEEUP00000004540 ENSEEUP00000004540 IL6 IL6 ENSEEUP00000004602 ENSEEUP00000004602 PPP1CB PPP1CB ENSEEUP00000004729 ENSEEUP00000004729 TGFB1 TGFB1 VDAC1 VDAC1 CCNB1 CCNB1 AKT3 AKT3 GEM GEM ENSEEUP00000008939 ENSEEUP00000008939 NFATC2 NFATC2 MAP2K6 MAP2K6 CAPN9 CAPN9 ENSEEUP00000010324 ENSEEUP00000010324 CALML4 CALML4 MAPK3 MAPK3 E2F3 E2F3 ENSEEUP00000010045 ENSEEUP00000010045 RASSF5 RASSF5 HUS1 HUS1 ENSEEUP00000009408 ENSEEUP00000009408 LOC103116007 LOC103116007 ENSEEUP00000009203 ENSEEUP00000009203 ENSEEUP00000009128 ENSEEUP00000009128 E2F1 E2F1 MAPK12 MAPK12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VDAC3Voltage-dependent anion-selective channel protein 3 isoform X2. (260 aa)
RBL1Retinoblastoma-like protein 1. (876 aa)
ENSEEUP00000008767annotation not available (130 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
HIPK1Homeodomain-interacting protein kinase 1 isoform X1. (915 aa)
ENSEEUP00000008412annotation not available (307 aa)
FOXM1Forkhead box protein M1 isoform X2. (611 aa)
EFCAB3EF-hand calcium-binding domain-containing protein 3. (437 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (556 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (376 aa)
VDAC2Voltage-dependent anion-selective channel protein 2. (257 aa)
RHEBL1GTPase RhebL1. (183 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (656 aa)
RBL2Retinoblastoma-like protein 2 isoform X2. (1136 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CDC25AM-phase inducer phosphatase 1. (509 aa)
RAD1Cell cycle checkpoint protein RAD1. (281 aa)
IGFBP3Insulin-like growth factor-binding protein 3. (156 aa)
ENSEEUP00000007255annotation not available (492 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3041 aa)
MYBL2Myb-related protein B isoform X1. (660 aa)
CDK1Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. (284 aa)
MRASRas-related protein M-Ras. (208 aa)
SMAD2Mothers against decapentaplegic homolog. (426 aa)
ENSEEUP00000006766annotation not available (668 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X2. (985 aa)
LIN9Protein lin-9 homolog. (511 aa)
LOC103117188H-2 class I histocompatibility antigen, Q10 alpha chain-like; Belongs to the MHC class I family. (255 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (495 aa)
PPP3CCSerine/threonine-protein phosphatase. (512 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
ENSEEUP00000005984annotation not available (444 aa)
ENSEEUP00000005868annotation not available (322 aa)
CSDE1Cold shock domain containing E1. (753 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2636 aa)
TPRG1Tumor protein p63-regulated gene 1 protein. (279 aa)
MAPK13Mitogen-activated protein kinase. (282 aa)
RASSF3Ras association domain-containing protein 3. (201 aa)
CDK3Cyclin-dependent kinase 3 isoform X1; Belongs to the protein kinase superfamily. (304 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (159 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2572 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (138 aa)
LIN52Protein lin-52 homolog. (116 aa)
TRAF3IP2Adapter protein CIKS isoform X1. (571 aa)
LIN37Protein lin-37 homolog. (180 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X2. (672 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (448 aa)
CAPN11Calpain-11; Belongs to the peptidase C2 family. (636 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1813 aa)
TGFBR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (469 aa)
TPRG1LTumor protein p63-regulated gene 1-like protein. (274 aa)
ENSEEUP00000012010annotation not available (149 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (475 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (595 aa)
E2F2Transcription factor E2F2. (431 aa)
LOC103126273HLA class I histocompatibility antigen, alpha chain G; Belongs to the MHC class I family. (334 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (94 aa)
LOC103128309Saoe class I histocompatibility antigen, A alpha chain-like; Belongs to the MHC class I family. (341 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (256 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (253 aa)
PPIDPeptidylprolyl isomerase D. (370 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
E2F4Transcription factor E2F4 isoform X1. (409 aa)
FOXO3Forkhead box protein O3. (469 aa)
E2F5Transcription factor E2F5. (269 aa)
HRASHRas proto-oncogene, GTPase. (173 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
ENSEEUP00000013398annotation not available (330 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2640 aa)
HIPK4Homeodomain-interacting protein kinase 4. (606 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (973 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (605 aa)
ENSEEUP00000013950annotation not available (889 aa)
HIPK3Homeodomain-interacting protein kinase 3 isoform X1. (1211 aa)
GATA4Transcription factor GATA-4 isoform X2. (241 aa)
ENSEEUP00000014174annotation not available (150 aa)
CAPN8Calpain-8; Belongs to the peptidase C2 family. (378 aa)
PPID-2Peptidyl-prolyl cis-trans isomerase D. (257 aa)
SQSTM1Sequestosome 1. (373 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa)
RB1Retinoblastoma-associated protein. (928 aa)
CALM3Calmodulin 3. (137 aa)
RRAS2Ras-related protein R-Ras2. (168 aa)
ENSEEUP00000000381annotation not available (210 aa)
CCNE1LOW QUALITY PROTEIN: G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (395 aa)
RAD50DNA repair protein RAD50 isoform X1. (1311 aa)
SLC25A5Solute carrier family 25 member 5. (295 aa)
ENSEEUP00000000720annotation not available (96 aa)
ENSEEUP00000000751annotation not available (1259 aa)
CCDC109BCalcium uniporter regulatory subunit MCUb, mitochondrial. (185 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (362 aa)
ENSEEUP00000001051annotation not available (621 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (413 aa)
LOC103127729Class I histocompatibility antigen, Gogo-B*0201 alpha chain-like isoform X2; Belongs to the MHC class I family. (300 aa)
ENSEEUP00000001616annotation not available (178 aa)
TSC2Tuberin isoform X5. (1551 aa)
LIN54Protein lin-54 homolog isoform X1. (618 aa)
MCUCalcium uniporter protein, mitochondrial. (325 aa)
CCNE2G1/S-specific cyclin-E2 isoform X2; Belongs to the cyclin family. (403 aa)
ENSEEUP00000002216annotation not available (543 aa)
SLC25A6ADP/ATP translocase 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (181 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (395 aa)
MAPK1Mitogen-activated protein kinase 1. (358 aa)
CALM2Calmodulin isoform X2; Belongs to the calmodulin family. (148 aa)
ETS1Protein C-ets-1 isoform X2. (439 aa)
RBBP4Histone-binding protein RBBP4 isoform X1. (425 aa)
KRASGTPase KRas isoform X1. (188 aa)
ENSEEUP00000002875annotation not available (494 aa)
LOC103127736Saoe class I histocompatibility antigen, A alpha chain-like; Belongs to the MHC class I family. (208 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (476 aa)
ENSEEUP00000003494annotation not available (302 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (226 aa)
CAPN12Calpain-12; Belongs to the peptidase C2 family. (705 aa)
TSC1Hamartin isoform X2. (1109 aa)
PPP3R2Calcineurin subunit B type 2. (173 aa)
GATA5Transcription factor GATA-5. (400 aa)
ENSEEUP00000004263annotation not available (951 aa)
ENSEEUP00000004392annotation not available (410 aa)
ENSEEUP00000004408annotation not available (370 aa)
ENSEEUP00000004540annotation not available (151 aa)
IL6Interleukin-6. (210 aa)
ENSEEUP00000004602annotation not available (190 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (309 aa)
ENSEEUP00000004729annotation not available (120 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
VDAC1Voltage dependent anion channel 1. (282 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (394 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
ENSEEUP00000008939annotation not available (570 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2. (918 aa)
MAP2K6Mitogen-activated protein kinase kinase 6. (334 aa)
CAPN9Calpain-9; Belongs to the peptidase C2 family. (682 aa)
ENSEEUP00000010324annotation not available (768 aa)
CALML4Calmodulin-like protein 4 isoform X1. (88 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
E2F3Transcription factor E2F3 isoform X1. (461 aa)
ENSEEUP00000010045annotation not available (1975 aa)
RASSF5Ras association domain-containing protein 5. (414 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (279 aa)
ENSEEUP00000009408annotation not available (229 aa)
LOC103116007LOW QUALITY PROTEIN: major histocompatibility complex class I-related gene protein; Belongs to the MHC class I family. (177 aa)
ENSEEUP00000009203annotation not available (294 aa)
ENSEEUP00000009128annotation not available (174 aa)
E2F1Transcription factor E2F1. (341 aa)
MAPK12Mitogen-activated protein kinase. (348 aa)
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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