STRINGSTRING
EHQ34176.1 EHQ34176.1 uvrA uvrA uvrC uvrC uvrB uvrB EHQ34361.1 EHQ34361.1 EHQ34368.1 EHQ34368.1 EHQ34375.1 EHQ34375.1 EHQ34433.1 EHQ34433.1 EHQ34466.1 EHQ34466.1 rnp2 rnp2 rnp3 rnp3 nth nth EHQ34733.1 EHQ34733.1 EHQ34754.1 EHQ34754.1 EHQ34781.1 EHQ34781.1 fen fen cas1 cas1 EHQ35072.1 EHQ35072.1 EHQ35106.1 EHQ35106.1 EHQ35472.1 EHQ35472.1 EHQ35612.1 EHQ35612.1 EHQ35615.1 EHQ35615.1 rnp4 rnp4 rnhB rnhB rnz rnz EHQ36004.1 EHQ36004.1 EHQ36008.1 EHQ36008.1 EHQ36012.1 EHQ36012.1 EHQ36019.1 EHQ36019.1 EHQ36072.1 EHQ36072.1 EHQ36175.1 EHQ36175.1 EHQ36180.1 EHQ36180.1 EHQ36205.1 EHQ36205.1 EHQ36250.1 EHQ36250.1 EHQ36270.1 EHQ36270.1 EHQ36299.1 EHQ36299.1 EHQ36309.1 EHQ36309.1 EHQ36404.1 EHQ36404.1 EHQ36409.1 EHQ36409.1 rpl7ae rpl7ae pelA pelA EHQ36701.1 EHQ36701.1 EHQ36720.1 EHQ36720.1 rnp1 rnp1 EHQ36890.1 EHQ36890.1 EHQ36987.1 EHQ36987.1 nfo nfo EHQ36997.1 EHQ36997.1 EHQ37088.1 EHQ37088.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EHQ34176.1PFAM: RNase3 domain; COGs: COG0571 dsRNA-specific ribonuclease; InterPro IPR000999; KEGG: mpi:Mpet_1497 ribonuclease III; PFAM: Ribonuclease III; SMART: Ribonuclease III; SPTR: Ribonuclease III. (156 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (977 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (523 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (649 aa)
EHQ34361.1PFAM: YcfA-like protein; InterPro IPR012933; KEGG: mpl:Mpal_1100 YcfA family protein; PFAM: YcfA-like; SPTR: YcfA family protein. (78 aa)
EHQ34368.1PFAM: YcfA-like protein; InterPro IPR012933; KEGG: fra:Francci3_0669 YcfA-like protein; PFAM: YcfA-like; SPTR: YcfA family protein. (72 aa)
EHQ34375.1PFAM: YcfA-like protein; InterPro IPR012933; KEGG: mpl:Mpal_1100 YcfA family protein; PFAM: YcfA-like; SPTR: YcfA family protein. (73 aa)
EHQ34433.1PFAM: YcfA-like protein; InterPro IPR012933; KEGG: mem:Memar_1246 YcfA family protein; PFAM: YcfA-like; SPTR: YcfA family protein. (75 aa)
EHQ34466.1Exodeoxyribonuclease III; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth); COGs: COG0708 Exonuclease III; InterPro IPR004808:IPR000097:IPR005135; KEGG: mpi:Mpet_1338 exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase; SPTR: Exodeoxyribonuclease III; TIGRFAM: AP endonuclease, family 1; Exodeoxyribonuclease III xth; manually curated. (256 aa)
rnp2Ribonuclease P protein subunit Rpp14; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family. (164 aa)
rnp3Ribonuclease P protein subunit Rpp30; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family. (215 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (217 aa)
EHQ34733.1PFAM: Type I restriction enzyme R protein N terminus (HSDR_N); Type III restriction enzyme, res subunit; COGs: COG0610 Type I site-specific restriction-modification system R (restriction) subunit and related helicase; InterPro IPR014001:IPR007409:IPR006935; KEGG: cby:CLM_2294 type III restriction protein res subunit; PFAM: Restriction endonuclease, type I, EcoRI, R subunit/Type III, Res subunit, N-terminal; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART: DEAD-like helicase, N-terminal; SPTR: Type III restriction protein res subunit. (1010 aa)
EHQ34754.1PFAM: YcfA-like protein; InterPro IPR012933; KEGG: nhl:Nhal_2505 hypothetical protein; PFAM: YcfA-like; SPTR: Putative uncharacterized protein. (77 aa)
EHQ34781.1PFAM: YcfA-like protein; COGs: COG1724 periplasmic or secreted lipoprotein; InterPro IPR012933; KEGG: mpi:Mpet_0478 YcfA family protein; PFAM: YcfA-like; SPTR: YcfA family protein. (72 aa)
fenFlap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] (333 aa)
cas1CRISPR-associated protein, Cas1 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (311 aa)
EHQ35072.1KEGG: mla:Mlab_0883 hypothetical protein; SPTR: Putative uncharacterized protein. (95 aa)
EHQ35106.1PFAM: Domain of unknown function DUF123; COGs: COG1833 conserved hypothetical protein; InterPro IPR002837; KEGG: mba:Mbar_A0396 endonuclease III; PFAM: Protein of unknown function DUF123; SPTR: Endonuclease III. (150 aa)
EHQ35472.1Exodeoxyribonuclease I subunit D; PFAM: Calcineurin-like phosphoesterase; Type 5 capsule protein repressor C terminal; TIGRFAM: exonuclease SbcD; COGs: COG0420 DNA repair exonuclease; InterPro IPR004593:IPR004843; KEGG: gur:Gura_1979 nuclease SbcCD, D subunit; PFAM: Metallophosphoesterase; SPTR: Exodeoxyribonuclease I subunit D; TIGRFAM: Exonuclease SbcD. (409 aa)
EHQ35612.1PFAM: Xylose isomerase-like TIM barrel; COGs: COG1082 Sugar phosphate isomerase/epimerase; InterPro IPR012307; KEGG: mpi:Mpet_1350 xylose isomerase domain-containing protein; PFAM: Xylose isomerase, TIM barrel domain; SPTR: Xylose isomerase domain protein TIM barrel. (241 aa)
EHQ35615.1Ribonuclease HIII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (353 aa)
rnp4Ribonuclease P protein subunit Rpp21; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (107 aa)
rnhBRNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (212 aa)
rnzRNAse Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (313 aa)
EHQ36004.1Uncharacterized protein family UPF0310; PFAM: Protein of unknown function DUF55; COGs: COG1673 conserved hypothetical protein; InterPro IPR002740; KEGG: mpi:Mpet_0775 hypothetical protein; PFAM: Uncharacterised protein family UPF0310; SPTR: Putative uncharacterized protein. (170 aa)
EHQ36008.1KEGG: mbn:Mboo_1034 hypothetical protein; SPTR: Putative uncharacterized protein. (97 aa)
EHQ36012.1Uncharacterized protein family UPF0310; PFAM: Protein of unknown function DUF55; COGs: COG1673 conserved hypothetical protein; InterPro IPR002740; KEGG: mpi:Mpet_0775 hypothetical protein; PFAM: Uncharacterised protein family UPF0310; SPTR: Putative uncharacterized protein. (182 aa)
EHQ36019.1Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase; COGs: COG0420 DNA repair exonuclease; InterPro IPR004843; KEGG: mba:Mbar_A0070 phosphoesterase; PFAM: Metallophosphoesterase; SPTR: Phosphoesterase. (434 aa)
EHQ36072.1KEGG: mpl:Mpal_0912 hypothetical protein; SPTR: Putative uncharacterized protein. (93 aa)
EHQ36175.1PFAM: YcfA-like protein; COGs: COG1724 periplasmic or secreted lipoprotein; InterPro IPR012933; KEGG: mhu:Mhun_2649 YcfA-like; PFAM: YcfA-like; SPTR: YcfA-like protein. (80 aa)
EHQ36180.1KEGG: pmx:PERMA_0669 putative methyltransferase type 11; SPTR: Putative methyltransferase type 11. (406 aa)
EHQ36205.1PFAM: YcfA-like protein; InterPro IPR012933; KEGG: mhu:Mhun_0399 YcfA-like; PFAM: YcfA-like; SPTR: YcfA-like protein. (76 aa)
EHQ36250.1PFAM: YcfA-like protein; InterPro IPR012933; KEGG: mpi:Mpet_1168 YcfA family protein; PFAM: YcfA-like; SPTR: YcfA family protein. (74 aa)
EHQ36270.1PFAM: Domain of unknown function (DUF3387); Type I restriction enzyme R protein N terminus (HSDR_N); Type III restriction enzyme, res subunit; TIGRFAM: type I site-specific deoxyribonuclease, HsdR family; COGs: COG0610 Type I site-specific restriction-modification system R (restriction) subunit and related helicase; InterPro IPR007409:IPR006935:IPR014001:IPR004473; KEGG: mpi:Mpet_1680 type I site-specific deoxyribonuclease; PFAM: Restriction endonuclease, type I, EcoRI, R subunit/Type III, Res subunit, N-terminal; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART [...] (1022 aa)
EHQ36299.1Hypothetical protein; COGs: COG1106 ATPase; KEGG: cju:C8J_1449 hypothetical protein; SPTR: RloA. (419 aa)
EHQ36309.1KEGG: tjr:TherJR_0428 SMC domain protein; SPTR: SMC domain protein. (636 aa)
EHQ36404.1PFAM: YcfA-like protein; InterPro IPR012933; KEGG: mem:Memar_0546 YcfA family protein; PFAM: YcfA-like; SPTR: Conserved domain protein. (74 aa)
EHQ36409.1PFAM: YcfA-like protein; InterPro IPR012933; KEGG: mif:Metin_1147 YcfA family protein; PFAM: YcfA-like; SPTR: YcfA family protein; manually curated. (71 aa)
rpl7aeLSU ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (122 aa)
pelACell division protein pelota; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. (340 aa)
EHQ36701.1PFAM: YcfA-like protein; InterPro IPR012933; KEGG: mhu:Mhun_0711 YcfA-like; PFAM: YcfA-like; SPTR: YcfA-like protein. (78 aa)
EHQ36720.1KEGG: hypothetical protein; SPTR: Putative uncharacterized protein. (252 aa)
rnp1Ribonuclease P protein subunit Rpp29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family. (93 aa)
EHQ36890.1PFAM: Beta propeller domain; COGs: COG4880 Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats; InterPro IPR019198; KEGG: mhu:Mhun_1971 hypothetical protein; PFAM: Beta propeller domain; SPTR: Putative uncharacterized protein. (675 aa)
EHQ36987.1Restriction endonuclease, type II, MjaII; PFAM: MjaII restriction endonuclease; InterPro IPR019045; KEGG: cyh:Cyan8802_4357 hypothetical protein; PFAM: Restriction endonuclease, type II, MjaII; SPTR: Putative uncharacterized protein. (289 aa)
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (281 aa)
EHQ36997.1PFAM: tRNA intron endonuclease, N-terminal domain; tRNA intron endonuclease, catalytic C-terminal domain; TIGRFAM: tRNA intron endonuclease; COGs: COG1676 tRNA splicing endonuclease; InterPro IPR006678:IPR006677:IPR006676; KEGG: mpi:Mpet_2568 tRNA intron endonuclease; PFAM: tRNA intron endonuclease, catalytic domain-like; tRNA intron endonuclease, N-terminal; SPTR: tRNA intron endonuclease; TIGRFAM: tRNA-intron endonuclease. (331 aa)
EHQ37088.1PFAM: Crossover junction endodeoxyribonuclease RuvC; TIGRFAM: crossover junction endodeoxyribonuclease RuvC; COGs: COG0817 Holliday junction resolvasome endonuclease subunit; HAMAP: Crossover junction endodeoxyribonuclease RuvC; InterPro IPR002176; KEGG: mbn:Mboo_0111 Holliday junction resolvase; PFAM: Crossover junction endodeoxyribonuclease RuvC; SPTR: Crossover junction endodeoxyribonuclease RuvC; TIGRFAM: Crossover junction endodeoxyribonuclease RuvC. (156 aa)
Your Current Organism:
Methanoplanus limicola
NCBI taxonomy Id: 937775
Other names: M. limicola DSM 2279, Methanoplanus limicola DSM 2279, Methanoplanus limicola str. DSM 2279, Methanoplanus limicola strain DSM 2279
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.