STRINGSTRING
EHQ34222.1 EHQ34222.1 pcn pcn priL priL dnaG dnaG rfcS rfcS EHQ34581.1 EHQ34581.1 smc smc fen fen EHQ34867.1 EHQ34867.1 dnaJ dnaJ dbh dbh EHQ35007.1 EHQ35007.1 polC polC EHQ35100.1 EHQ35100.1 EHQ35284.1 EHQ35284.1 EHQ35383.1 EHQ35383.1 EHQ35415.1 EHQ35415.1 polB polB EHQ35579.1 EHQ35579.1 EHQ35676.1 EHQ35676.1 priS priS rfcL rfcL top6B top6B top6A top6A lig lig EHQ37015.1 EHQ37015.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
EHQ34222.1Ribonucleoside-triphosphate reductase class III catalytic subunit; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; intein N-terminal splicing region; COGs: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; InterPro IPR003587:IPR012833:IPR006141; KEGG: mpi:Mpet_1249 anaerobic ribonucleoside-triphosphate reductase; SMART: Hedgehog/intein hint, N-terminal; SPTR: Anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; Intein splicing site. (1212 aa)
pcnMonomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. (247 aa)
priLDNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (381 aa)
dnaGUPF0095 protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (403 aa)
rfcSReplication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (325 aa)
EHQ34581.1Replication factor C; PFAM: ATPase family associated with various cellular activities (AAA); Replication factor C; COGs: COG2812 DNA polymerase III gamma/tau subunits; InterPro IPR003959:IPR013748; KEGG: mpi:Mpet_0988 replication factor C; PFAM: Replication factor C; ATPase, AAA-type, core; SPTR: Replication factor C. (332 aa)
smcCondensin subunit Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1146 aa)
fenFlap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] (333 aa)
EHQ34867.1Hypothetical protein; KEGG: mpi:Mpet_0705 nucleic acid binding OB-fold tRNA/helicase-type protein; SPTR: Nucleic acid binding, OB-fold, tRNA/helicase-type. (560 aa)
dnaJChaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (379 aa)
dbhDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (364 aa)
EHQ35007.1Heat shock protein DnaJ domain protein; PFAM: DnaJ domain; COGs: COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; InterPro IPR001623; KEGG: mpi:Mpet_0567 heat shock protein DnaJ domain-containing protein; PFAM: Heat shock protein DnaJ, N-terminal; SMART: Heat shock protein DnaJ, N-terminal; SPTR: Heat shock protein DnaJ domain protein. (211 aa)
polCDNA polymerase II large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1299 aa)
EHQ35100.1ATP-dependent DNA helicase RecQ; PFAM: Helicase conserved C-terminal domain; RQC domain; HRDC domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase RecQ; ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR014001:IPR001650:IPR002121:IPR011545:IPR 018982:IPR006293:IPR018329; KEGG: mac:MA4507 DNA helicase RecQ; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DNA/RNA helicase, C-terminal; RQC domain; Helicase/RNase D C-terminal, HRDC domain; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; Helicase/RNase [...] (720 aa)
EHQ35284.1COGs: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; KEGG: mpi:Mpet_0149 oxygen-sensitive ribonucleoside-triphosphate reductase-like protein; SPTR: Oxygen-sensitive ribonucleoside-triphosphate reductase-like protein. (120 aa)
EHQ35383.1ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (379 aa)
EHQ35415.1ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (439 aa)
polBDNA polymerase II small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (497 aa)
EHQ35579.1ATP-dependent DNA helicase, RecQ family; PFAM: Helicase conserved C-terminal domain; RQC domain; HRDC domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase RecQ; ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR014001:IPR001650:IPR018329:IPR011545:IPR 018982:IPR002121; KEGG: rci:RCIX1772 ATP-dependent DNA helicase; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DNA/RNA helicase, C-terminal; RQC domain; Helicase/RNase D C-terminal, HRDC domain; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: [...] (1165 aa)
EHQ35676.1PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR006172:IPR006133:IPR006134; KEGG: mpi:Mpet_1929 DNA polymerase B region; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; SPTR: DNA polymerase. (843 aa)
priSDNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (380 aa)
rfcLReplication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (497 aa)
top6BDNA topoisomerase VI, B subunit; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (600 aa)
top6AType 2 DNA topoisomerase 6 subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (362 aa)
ligDNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (549 aa)
EHQ37015.1Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (545 aa)
Your Current Organism:
Methanoplanus limicola
NCBI taxonomy Id: 937775
Other names: M. limicola DSM 2279, Methanoplanus limicola DSM 2279, Methanoplanus limicola str. DSM 2279, Methanoplanus limicola strain DSM 2279
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