STRINGSTRING
mutL mutL EHQ35761.1 EHQ35761.1 EHQ35883.1 EHQ35883.1 EHQ35996.1 EHQ35996.1 EHQ36202.1 EHQ36202.1 EHQ36270.1 EHQ36270.1 rfcL rfcL top6B top6B top6A top6A EHQ37037.1 EHQ37037.1 ruvB ruvB EHQ37087.1 EHQ37087.1 EHQ34347.1 EHQ34347.1 EHQ34549.1 EHQ34549.1 EHQ34554.1 EHQ34554.1 rfcS rfcS EHQ34785.1 EHQ34785.1 gyrA gyrA gyrB gyrB radA radA hel308 hel308 EHQ35684.1 EHQ35684.1 radB radB mutS mutS
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (705 aa)
EHQ35761.1PFAM: Domain of unknown function DUF87; COGs: COG0433 ATPase; InterPro IPR002789; KEGG: mpi:Mpet_1861 hypothetical protein; PFAM: Protein of unknown function DUF87; SPTR: Putative uncharacterized protein. (610 aa)
EHQ35883.1UvrD/REP helicase; PFAM: Domain of unknown function DUF83; Nuclease-related domain; UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR011528:IPR000212; KEGG: mma:MM_0190 DNA helicase II; PFAM: DNA helicase, UvrD/REP type; NERD; SPTR: DNA helicase II. (1332 aa)
EHQ35996.1Helicase domain-containing protein; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain; COGs: COG0553 Superfamily II DNA/RNA helicase SNF2 family; InterPro IPR000330:IPR001650:IPR014001; KEGG: mca:MCA3005 DEAD-box ATP dependent DNA helicase; PFAM: DNA/RNA helicase, C-terminal; SNF2-related; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: ATP-dependent RNA helicase, DEAD/DEAH box family. (1192 aa)
EHQ36202.1PFAM: Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit; COGs: COG1061 DNA or RNA helicase of superfamily II; InterPro IPR006935:IPR001650:IPR014001; KEGG: hla:Hlac_3022 type III restriction protein res subunit; PFAM: Restriction endonuclease, type I, R subunit/Type III, Res subunit; DNA/RNA helicase, C-terminal; SMART: DNA/RNA helicase, C-terminal; DEAD-like helicase, N-terminal; SPTR: Type III restriction protein res subunit. (986 aa)
EHQ36270.1PFAM: Domain of unknown function (DUF3387); Type I restriction enzyme R protein N terminus (HSDR_N); Type III restriction enzyme, res subunit; TIGRFAM: type I site-specific deoxyribonuclease, HsdR family; COGs: COG0610 Type I site-specific restriction-modification system R (restriction) subunit and related helicase; InterPro IPR007409:IPR006935:IPR014001:IPR004473; KEGG: mpi:Mpet_1680 type I site-specific deoxyribonuclease; PFAM: Restriction endonuclease, type I, EcoRI, R subunit/Type III, Res subunit, N-terminal; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART [...] (1022 aa)
rfcLReplication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (497 aa)
top6BDNA topoisomerase VI, B subunit; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (600 aa)
top6AType 2 DNA topoisomerase 6 subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (362 aa)
EHQ37037.1PFAM: UvrD/REP helicase; COGs: COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains); InterPro IPR000212; KEGG: mem:Memar_1498 UvrD/REP helicase; PFAM: DNA helicase, UvrD/REP type; SPTR: UvrD/REP helicase. (1127 aa)
ruvBHolliday junction DNA helicase subunit RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (332 aa)
EHQ37087.1PFAM: RuvA, C-terminal domain; RuvA N terminal domain; TIGRFAM: Holliday junction DNA helicase, RuvA subunit; COGs: COG0632 Holliday junction resolvasome DNA-binding subunit; HAMAP: Holliday junction ATP-dependent DNA helicase ruvA; InterPro IPR013849:IPR011114:IPR000085:IPR003583; KEGG: mbn:Mboo_0112 Holliday junction DNA helicase RuvA; PFAM: DNA helicase, Holliday junction RuvA type, domain I, bacterial; DNA helicase, Holliday junction RuvA type, domain III, C-terminal; SPTR: Holliday junction DNA helicase RuvA; TIGRFAM: Bacterial DNA recombination protein RuvA. (199 aa)
EHQ34347.1PFAM: SNF2 Helicase protein; Helicase conserved C-terminal domain; SNF2 family N-terminal domain; COGs: COG0553 Superfamily II DNA/RNA helicase SNF2 family; InterPro IPR000330:IPR001650:IPR014001; KEGG: SNF2 family helicase; PFAM: SNF2-related; DNA/RNA helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: Probable helicase, Snf2/Rad54 family. (1015 aa)
EHQ34549.1Helicase domain-containing protein; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain; COGs: COG0553 Superfamily II DNA/RNA helicase SNF2 family; InterPro IPR014001:IPR001650:IPR000330; KEGG: cyn:Cyan7425_5359 helicase domain protein; PFAM: DNA/RNA helicase, C-terminal; SNF2-related; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: Helicase domain protein. (1090 aa)
EHQ34554.1PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; COGs: COG1204 Superfamily II helicase; InterPro IPR014001:IPR001650:IPR011545; KEGG: mfa:Mfla_1218 DEAD/DEAH box helicase-like protein; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DNA/RNA helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: DEAD/DEAH box helicase-like protein. (1053 aa)
rfcSReplication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (325 aa)
EHQ34785.1Helicase domain-containing protein; PFAM: Helicase conserved C-terminal domain; Helix-hairpin-helix motif; DEAD/DEAH box helicase; COGs: COG1111 ERCC4-like helicase; InterProIPR011545:IPR001650:IPR006166:IPR000445:IPR 014001:IPR003583; KEGG: mpi:Mpet_0792 helicase domain-containing protein; PFAM: DNA/RNA helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; ERCC4 domain; Helix-hairpin-helix motif; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; Helix-hairpin-helix DNA-binding motif, class 1; SPTR: Helicase domain protein. (776 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (856 aa)
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (639 aa)
radADNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (324 aa)
hel308Ski2-type helicase; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (787 aa)
EHQ35684.1DEAD_2 domain protein; PFAM: DEAD_2; COGs: COG1199 Rad3-related DNA helicase; InterPro IPR006554:IPR006555:IPR010614; KEGG: mpi:Mpet_1921 DEAD_2 domain-containing protein; PFAM: DEAD2; SMART: Helicase, ATP-dependent, c2 type; Helicase-like, DEXD box c2 type; SPTR: DEAD_2 domain protein. (665 aa)
radBDNA repair and recombination protein radB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. (225 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (944 aa)
Your Current Organism:
Methanoplanus limicola
NCBI taxonomy Id: 937775
Other names: M. limicola DSM 2279, Methanoplanus limicola DSM 2279, Methanoplanus limicola str. DSM 2279, Methanoplanus limicola strain DSM 2279
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