STRINGSTRING
EHQ35075.1 EHQ35075.1 EHQ34202.1 EHQ34202.1 EHQ34544.1 EHQ34544.1 EHQ34552.1 EHQ34552.1 tbp tbp EHQ34576.1 EHQ34576.1 EHQ34701.1 EHQ34701.1 EHQ34747.1 EHQ34747.1 EHQ34788.1 EHQ34788.1 tbp-2 tbp-2 fen fen EHQ34862.1 EHQ34862.1 radA radA EHQ34867.1 EHQ34867.1 flpA flpA truB truB EHQ35287.1 EHQ35287.1 EHQ35289.1 EHQ35289.1 rpl40e rpl40e EHQ35383.1 EHQ35383.1 EHQ35415.1 EHQ35415.1 pdxS pdxS EHQ35564.1 EHQ35564.1 EHQ35684.1 EHQ35684.1 radB radB EHQ35729.1 EHQ35729.1 mutS mutS EHQ35824.1 EHQ35824.1 nop10 nop10 tfe tfe EHQ36097.1 EHQ36097.1 EHQ36164.1 EHQ36164.1 EHQ36202.1 EHQ36202.1 EHQ36307.1 EHQ36307.1 EHQ36485.1 EHQ36485.1 EHQ36505.1 EHQ36505.1 EHQ36567.1 EHQ36567.1 rps8e rps8e EHQ36661.1 EHQ36661.1 top6A top6A EHQ36880.1 EHQ36880.1 lig lig nfo nfo EHQ36997.1 EHQ36997.1 EHQ37056.1 EHQ37056.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EHQ35075.1rRNA biogenesis protein Nop56/Nop58; PFAM: Putative snoRNA binding domain; COGs: COG1498 Protein implicated in ribosomal biogenesis Nop56p homolog; InterPro IPR002687; KEGG: mpi:Mpet_0393 pre-mRNA processing ribonucleoprotein, binding domain-containing protein; PFAM: Pre-mRNA processing ribonucleoprotein, binding region; SPTR: Pre-mRNA processing ribonucleoprotein, binding domain protein. (301 aa)
EHQ34202.1PFAM: Uracil DNA glycosylase superfamily; COGs: COG3663 G:T/U mismatch-specific DNA glycosylase; KEGG: mpi:Mpet_1152 hypothetical protein; SPTR: Putative uncharacterized protein. (180 aa)
EHQ34544.1PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; COGs: COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster; InterPro IPR014001:IPR001650:IPR011545; KEGG: aoe:Clos_1857 DEAD/DEAH box helicase domain-containing protein; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DNA/RNA helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: DEAD/DEAH box helicase domain protein. (1970 aa)
EHQ34552.1DEAD/DEAH box helicase domain protein; PFAM: Helicase conserved C-terminal domain; Domain of unknown function (DUF1998); DEAD/DEAH box helicase; COGs: COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster; InterPro IPR014001:IPR001650:IPR011545:IPR018973; KEGG: ttm:Tthe_0932 protein of unknown function DUF1998; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DNA/RNA helicase, C-terminal; Protein of unknown function DUF1998; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: Putative uncharacterized protein. (1782 aa)
tbpTATA binding protein of transcription factor TFIID; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (184 aa)
EHQ34576.1PFAM: NMD3 family; COGs: COG1499 NMD protein affecting ribosome stability and mRNA decay; InterPro IPR007064; KEGG: mpi:Mpet_0983 NMD3 family protein; PFAM: NMD3; SPTR: NMD3 family protein. (351 aa)
EHQ34701.1RNP-1 like RNA-binding protein; PFAM: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain); COGs: COG0724 RNA-binding protein (RRM domain); InterPro IPR000504; KEGG: mpi:Mpet_1163 RNP-1 like RNA-binding protein; PFAM: RNA recognition motif, RNP-1; SMART: RNA recognition motif, RNP-1; SPTR: RNP-1 like RNA-binding protein. (83 aa)
EHQ34747.1AMP-dependent synthetase and ligase; PFAM: AMP-binding enzyme; COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR000873; KEGG: mpi:Mpet_0800 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase/ligase; SPTR: AMP-dependent synthetase and ligase. (566 aa)
EHQ34788.1Protein of unknown function UPF0047; PFAM: Uncharacterised protein family UPF0047; TIGRFAM: secondary thiamine-phosphate synthase enzyme; COGs: COG0432 conserved hypothetical protein; InterPro IPR001602; KEGG: mpi:Mpet_0789 hypothetical protein; PFAM: Uncharacterised protein family UPF0047; SPTR: Putative uncharacterized protein; TIGRFAM: Uncharacterised protein family UPF0047. (138 aa)
tbp-2TATA binding protein of transcription factor TFIID; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (186 aa)
fenFlap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] (333 aa)
EHQ34862.1PFAM: Nucleolar GTP-binding protein 1 (NOG1); COGs: COG1084 GTPase; InterPro IPR002917; KEGG: mpi:Mpet_0710 GTP-binding protein HSR1-like protein; PFAM: GTP-binding protein, HSR1-related; SPTR: GTP-binding protein HSR1-related protein. (325 aa)
radADNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (324 aa)
EHQ34867.1Hypothetical protein; KEGG: mpi:Mpet_0705 nucleic acid binding OB-fold tRNA/helicase-type protein; SPTR: Nucleic acid binding, OB-fold, tRNA/helicase-type. (560 aa)
flpArRNA 2'-O-methyltransferase fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (204 aa)
truBtRNA pseudouridine synthase B; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (313 aa)
EHQ35287.1PFAM: OB-fold nucleic acid binding domain; COGs: COG1599 Single-stranded DNA-binding replication protein A (RPA) large (70 kD) subunit and related ssDNA-binding protein; InterPro IPR004365; KEGG: mpi:Mpet_0146 nucleic acid binding OB-fold tRNA/helicase-type protein; PFAM: Nucleic acid binding, OB-fold, tRNA/helicase-type; SPTR: Nucleic acid binding OB-fold tRNA/helicase-type. (417 aa)
EHQ35289.1PFAM: OB-fold nucleic acid binding domain; COGs: COG1599 Single-stranded DNA-binding replication protein A (RPA) large (70 kD) subunit and related ssDNA-binding protein; InterPro IPR004365; KEGG: mpi:Mpet_0146 nucleic acid binding OB-fold tRNA/helicase-type protein; PFAM: Nucleic acid binding, OB-fold, tRNA/helicase-type; SPTR: Nucleic acid binding OB-fold tRNA/helicase-type. (424 aa)
rpl40ePFAM: Ribosomal L40e family; HAMAP: 50S ribosomal protein L40e; InterPro IPR001975; KEGG: mpi:Mpet_0113 50S ribosomal protein L40e; PFAM: Ribosomal protein L40e; SPTR: 50S ribosomal protein L40e; manually curated; Belongs to the eukaryotic ribosomal protein eL40 family. (48 aa)
EHQ35383.1ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (379 aa)
EHQ35415.1ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (439 aa)
pdxSPyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (314 aa)
EHQ35564.1PFAM: ZPR1 zinc-finger domain; TIGRFAM: ZPR1-related zinc finger protein; ZPR1 zinc finger domain; COGs: COG1779 C4-type Zn-finger protein; InterPro IPR004457:IPR004470; KEGG: mpi:Mpet_2653 ZPR1-like zinc finger protein; SPTR: ZPR1-related zinc finger protein; TIGRFAM: Zinc finger, ZPR1-type, subgroup; Zinc finger, ZPR1-type. (175 aa)
EHQ35684.1DEAD_2 domain protein; PFAM: DEAD_2; COGs: COG1199 Rad3-related DNA helicase; InterPro IPR006554:IPR006555:IPR010614; KEGG: mpi:Mpet_1921 DEAD_2 domain-containing protein; PFAM: DEAD2; SMART: Helicase, ATP-dependent, c2 type; Helicase-like, DEXD box c2 type; SPTR: DEAD_2 domain protein. (665 aa)
radBDNA repair and recombination protein radB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. (225 aa)
EHQ35729.1AMP-dependent synthetase and ligase; PFAM: AMP-binding enzyme; COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR000873; KEGG: mpi:Mpet_1896 AMP-dependent synthetase and ligase; PFAM: AMP-dependent synthetase/ligase; SPTR: AMP-dependent synthetase and ligase. (533 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (944 aa)
EHQ35824.1ADP-ribosylation/Crystallin J1; PFAM: ADP-ribosylglycohydrolase; COGs: COG1397 ADP-ribosylglycohydrolase; InterPro IPR005502; KEGG: mpl:Mpal_0950 ADP-ribosylation/crystallin J1; PFAM: ADP-ribosylation/Crystallin J1; SPTR: ADP-ribosylation/Crystallin J1. (286 aa)
nop10Ribosome biogenesis protein Nop10; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (56 aa)
tfeTranscription factor IIE (TFIIE), alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elo [...] (173 aa)
EHQ36097.1PFAM: Histone deacetylase domain; COGs: COG0123 Deacetylase including yeast histone deacetylase and acetoin utilization protein; InterPro IPR000286; KEGG: mhu:Mhun_0929 histone deacetylase superfamily protein; PFAM: Histone deacetylase superfamily; SPTR: Histone deacetylase superfamily. (358 aa)
EHQ36164.1DEAD/DEAH box helicase domain protein; PFAM: Helicase conserved C-terminal domain; Domain of unknown function (DUF1998); DEAD/DEAH box helicase; COGs: COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster; InterPro IPR011545:IPR001650:IPR018973:IPR014001; KEGG: mst:Msp_0367 helicase; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DNA/RNA helicase, C-terminal; Protein of unknown function DUF1998; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: Predicted helicase. (855 aa)
EHQ36202.1PFAM: Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit; COGs: COG1061 DNA or RNA helicase of superfamily II; InterPro IPR006935:IPR001650:IPR014001; KEGG: hla:Hlac_3022 type III restriction protein res subunit; PFAM: Restriction endonuclease, type I, R subunit/Type III, Res subunit; DNA/RNA helicase, C-terminal; SMART: DNA/RNA helicase, C-terminal; DEAD-like helicase, N-terminal; SPTR: Type III restriction protein res subunit. (986 aa)
EHQ36307.1Type III restriction protein res subunit; PFAM: NgoFVII restriction endonuclease; Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit; Domain of unknown function (DUF3427); COGs: COG1061 DNA or RNA helicase of superfamily II; InterPro IPR006935:IPR001650:IPR014001; KEGG: mem:Memar_0449 type III restriction enzyme, res subunit; PFAM: Restriction endonuclease, type I, R subunit/Type III, Res subunit; DNA/RNA helicase, C-terminal; SMART: DNA/RNA helicase, C-terminal; DEAD-like helicase, N-terminal; SPTR: Type III restriction enzyme, res subunit. (1054 aa)
EHQ36485.1O-acetylhomoserine sulfhydrolase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase; COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR000277:IPR006235; KEGG: mbn:Mboo_1994 O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; SPTR: O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase. (431 aa)
EHQ36505.1DEAD/DEAH box helicase domain protein; PFAM: Helicase conserved C-terminal domain; Domain of unknown function (DUF1998); DEAD/DEAH box helicase; COGs: COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster; InterPro IPR011545:IPR001650:IPR018973:IPR014001; KEGG: gym:GYMC10_1045 DEAD/DEAH box helicase domain protein; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DNA/RNA helicase, C-terminal; Protein of unknown function DUF1998; SMART: DEAD-like helicase, N-terminal; SPTR: DEAD/DEAH box helicase domain protein. (1763 aa)
EHQ36567.1snoRNP protein GAR1; PFAM: Gar1/Naf1 RNA binding region; KEGG: mpi:Mpet_2177 hypothetical protein; SPTR: Putative uncharacterized protein. (77 aa)
rps8ePFAM: Ribosomal protein S8e; TIGRFAM: ribosomal protein S8.e; COGs: COG2007 Ribosomal protein S8E; HAMAP: 30S ribosomal protein S8e; InterPro IPR001047; KEGG: mpi:Mpet_2173 30S ribosomal protein S8e; PFAM: Ribosomal protein S8e; SPTR: 30S ribosomal protein S8e; TIGRFAM: Ribosomal protein S8e. (125 aa)
EHQ36661.1Adenylyl cyclase CyaB; PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative; COGs: COG1437 Adenylate cyclase class 2 (thermophilic); InterPro IPR008172:IPR008173; KEGG: mpi:Mpet_2078 adenylyl cyclase CyaB; PFAM: Adenylate cyclase; SPTR: Adenylyl cyclase CyaB; TIGRFAM: Adenylyl cyclase CyaB. (178 aa)
top6AType 2 DNA topoisomerase 6 subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (362 aa)
EHQ36880.1Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (170 aa)
ligDNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (549 aa)
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (281 aa)
EHQ36997.1PFAM: tRNA intron endonuclease, N-terminal domain; tRNA intron endonuclease, catalytic C-terminal domain; TIGRFAM: tRNA intron endonuclease; COGs: COG1676 tRNA splicing endonuclease; InterPro IPR006678:IPR006677:IPR006676; KEGG: mpi:Mpet_2568 tRNA intron endonuclease; PFAM: tRNA intron endonuclease, catalytic domain-like; tRNA intron endonuclease, N-terminal; SPTR: tRNA intron endonuclease; TIGRFAM: tRNA-intron endonuclease. (331 aa)
EHQ37056.1ADP-ribosylation/Crystallin J1; PFAM: ADP-ribosylglycohydrolase; COGs: COG1397 ADP-ribosylglycohydrolase; InterPro IPR005502; KEGG: mpi:Mpet_2606 ADP-ribosylation/crystallin J1; PFAM: ADP-ribosylation/Crystallin J1; SPTR: ADP-ribosylation/Crystallin J1. (300 aa)
Your Current Organism:
Methanoplanus limicola
NCBI taxonomy Id: 937775
Other names: M. limicola DSM 2279, Methanoplanus limicola DSM 2279, Methanoplanus limicola str. DSM 2279, Methanoplanus limicola strain DSM 2279
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