54 items (Pteropus alecto) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	L5JMY0_PTEAL	Clathrin coat assembly protein AP180. (800 aa)
	MYO6	Myosin-VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1275 aa)
	L5JQE6_PTEAL	FCH and double SH3 domains protein 2. (178 aa)
	NUMB	Protein numb like protein. (707 aa)
	L5JQN5_PTEAL	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1532 aa)
	L5JQP3_PTEAL	Phosphatidylinositol-binding clathrin assembly protein. (688 aa)
	L5JQT4_PTEAL	AP complex subunit beta. (1042 aa)
	AP2M1	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family. (433 aa)
	LDLR	Low-density lipoprotein receptor. (881 aa)
	L5L3S4_PTEAL	Phosphatidylinositol-binding clathrin assembly protein. (166 aa)
	L5L4F8_PTEAL	AP-1 complex subunit beta-1. (152 aa)
	AP2A1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (947 aa)
	L5L6V3_PTEAL	FCH domain only protein 1. (746 aa)
	EPS15L1	Epidermal growth factor receptor substrate 15-like 1. (929 aa)
	DNM2	Dynamin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (839 aa)
	TNK2	Activated CDC42 kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1737 aa)
	CUBN	Cubilin. (3499 aa)
	AP1S3	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (174 aa)
	DGKD	Diacylglycerol kinase. (1173 aa)
	APP	Amyloid beta A4 protein. (748 aa)
	L5KXI6_PTEAL	Ras-related protein Rab-35. (258 aa)
	CLTCL1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1669 aa)
	L5KUZ1_PTEAL	AP2-associated protein kinase 1. (1334 aa)
	L5KUQ6_PTEAL	Clathrin heavy chain linker domain-containing protein 1. (411 aa)
	SH3BP4	SH3 domain-binding protein 4. (966 aa)
	HIP1R	Huntingtin-interacting protein 1-related protein. (1691 aa)
	L5KTJ3_PTEAL	AP-2 complex subunit beta. (151 aa)
	ITSN2	Intersectin-2. (1208 aa)
	ACKR3	C-X-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	L5KRN9_PTEAL	AP-1 complex subunit beta-1. (52 aa)
	L5KRF5_PTEAL	Intersectin-2. (488 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (913 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (218 aa)
	FCHO2	FCH domain only protein 2. (916 aa)
	DNM1L	Dynamin-1-like protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (738 aa)
	ATAT1	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (421 aa)
	REPS1	RalBP1-associated Eps domain-containing protein 1. (796 aa)
	SLC18A3	Vesicular acetylcholine transporter. (529 aa)
	L5K8E9_PTEAL	FCH and double SH3 domains protein 2. (535 aa)
	AP1S1	AP-1 complex subunit sigma-1A. (401 aa)
	L5K5V2_PTEAL	Sortilin. (838 aa)
	EPS15	Epidermal growth factor receptor substrate 15. (1196 aa)
	VLDLR	Very low-density lipoprotein receptor. (874 aa)
	TCTEX1D1	SH3-containing GRB2-like protein 3-interacting protein 1. (916 aa)
	DAB2	Disabled like protein 2. (733 aa)
	ITSN1	Intersectin-1. (1376 aa)
	L5K006_PTEAL	Low-density lipoprotein receptor-related protein 2. (4395 aa)
	INPP5F	Phosphatidylinositide phosphatase SAC2. (1075 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1039 aa)
	L5JYI5_PTEAL	Intersectin-1. (365 aa)
	L5JVP5_PTEAL	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (91 aa)
	L5JVN1_PTEAL	Dynamin-1-like protein. (192 aa)
	CLTB	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (155 aa)
	EPN3	Epsin-3. (257 aa)

Your Current Organism:

Pteropus alecto

NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP1S1	AP1S3	L5K6E5	L5L0I5	AP-1 complex subunit sigma-1A.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.932
AP1S1	AP2A1	L5K6E5	L5L4G2	AP-1 complex subunit sigma-1A.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.738
AP1S1	AP2A2	L5K6E5	L5KPE8	AP-1 complex subunit sigma-1A.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.464
AP1S1	AP2M1	L5K6E5	L5JRJ0	AP-1 complex subunit sigma-1A.	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.	0.516
AP1S1	CLTA	L5K6E5	L5KP86	AP-1 complex subunit sigma-1A.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.695
AP1S1	CLTB	L5K6E5	L5JV04	AP-1 complex subunit sigma-1A.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.687
AP1S1	CLTCL1	L5K6E5	L5KVR0	AP-1 complex subunit sigma-1A.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.660
AP1S1	DNM2	L5K6E5	L5L2G1	AP-1 complex subunit sigma-1A.	Dynamin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.480
AP1S1	HIP1R	L5K6E5	L5KTZ1	AP-1 complex subunit sigma-1A.	Huntingtin-interacting protein 1-related protein.	0.474
AP1S1	L5JQN5_PTEAL	L5K6E5	L5JQN5	AP-1 complex subunit sigma-1A.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.712
AP1S1	L5JQT4_PTEAL	L5K6E5	L5JQT4	AP-1 complex subunit sigma-1A.	AP complex subunit beta.	0.760
AP1S1	L5JVP5_PTEAL	L5K6E5	L5JVP5	AP-1 complex subunit sigma-1A.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.618
AP1S1	L5K5V2_PTEAL	L5K6E5	L5K5V2	AP-1 complex subunit sigma-1A.	Sortilin.	0.568
AP1S1	L5KRN9_PTEAL	L5K6E5	L5KRN9	AP-1 complex subunit sigma-1A.	AP-1 complex subunit beta-1.	0.760
AP1S1	L5KTJ3_PTEAL	L5K6E5	L5KTJ3	AP-1 complex subunit sigma-1A.	AP-2 complex subunit beta.	0.641
AP1S1	L5KUQ6_PTEAL	L5K6E5	L5KUQ6	AP-1 complex subunit sigma-1A.	Clathrin heavy chain linker domain-containing protein 1.	0.477
AP1S1	L5L4F8_PTEAL	L5K6E5	L5L4F8	AP-1 complex subunit sigma-1A.	AP-1 complex subunit beta-1.	0.641
AP1S3	AP1S1	L5L0I5	L5K6E5	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP-1 complex subunit sigma-1A.	0.932
AP1S3	AP2A1	L5L0I5	L5L4G2	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.760
AP1S3	AP2A2	L5L0I5	L5KPE8	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.412