STRINGSTRING
MMP15 MMP15 L5KVM5_PTEAL L5KVM5_PTEAL ITGB1 ITGB1 MEGF8 MEGF8 DVL1 DVL1 TLX2 TLX2 ITGA5 ITGA5 PAF1 PAF1 L5L4T5_PTEAL L5L4T5_PTEAL ITGB5 ITGB5 CTR9 CTR9 L5L3V4_PTEAL L5L3V4_PTEAL DUSP1 DUSP1 HAND1 HAND1 APLNR APLNR L5L1M8_PTEAL L5L1M8_PTEAL SMAD1 SMAD1 FN1 FN1 L5L187_PTEAL L5L187_PTEAL SFRP2 SFRP2 L5L0D8_PTEAL L5L0D8_PTEAL CUL3 CUL3 L5L000_PTEAL L5L000_PTEAL EXT2 EXT2 TBX19 TBX19 L5KXJ7_PTEAL L5KXJ7_PTEAL RNF2 RNF2 AMOT AMOT L5KWI4_PTEAL L5KWI4_PTEAL L5KW93_PTEAL L5KW93_PTEAL COL4A2 COL4A2 COL12A1 COL12A1 WNT11 WNT11 L5JM54_PTEAL L5JM54_PTEAL L5JN10_PTEAL L5JN10_PTEAL LMBRD1 LMBRD1 L5JNB4_PTEAL L5JNB4_PTEAL SRF SRF TENM4 TENM4 GPI GPI INHBA INHBA LAMB1 LAMB1 NOG NOG LHX1 LHX1 FOXF1 FOXF1 VTN VTN ITGA3 ITGA3 EYA1 EYA1 FRS2 FRS2 SYF2 SYF2 ZIC3 ZIC3 L5JUZ8_PTEAL L5JUZ8_PTEAL L5JV73_PTEAL L5JV73_PTEAL L5JVY2_PTEAL L5JVY2_PTEAL POFUT2 POFUT2 COL6A1 COL6A1 L5JXP1_PTEAL L5JXP1_PTEAL L5JY48_PTEAL L5JY48_PTEAL L5JYK8_PTEAL L5JYK8_PTEAL ARFRP1 ARFRP1 L5JZ72_PTEAL L5JZ72_PTEAL TP53 TP53 UGDH UGDH L5JZH0_PTEAL L5JZH0_PTEAL BMPR2 BMPR2 DVL2 DVL2 L5K0K6_PTEAL L5K0K6_PTEAL OTX2 OTX2 BMP4 BMP4 DUSP5 DUSP5 LDB1 LDB1 SMAD3 SMAD3 LEO1 LEO1 SMAD4 SMAD4 RTF1 RTF1 ITGAV ITGAV GATA6 GATA6 TWSG1 TWSG1 PLPP3 PLPP3 L5K3G8_PTEAL L5K3G8_PTEAL L5K3Q7_PTEAL L5K3Q7_PTEAL L5K3U3_PTEAL L5K3U3_PTEAL LEF1 LEF1 L5K5E3_PTEAL L5K5E3_PTEAL CRB2 CRB2 TAL1 TAL1 PRKACA PRKACA NR0B1 NR0B1 CER1 CER1 RIC8A RIC8A EXT1 EXT1 ATOH8 ATOH8 KDM6A KDM6A COL8A1 COL8A1 FAM208A FAM208A ARMC5 ARMC5 DUSP4 DUSP4 TAF10 TAF10 BMPR1A BMPR1A SFRP1 SFRP1 NODAL NODAL L5KDL8_PTEAL L5KDL8_PTEAL L5KEI8_PTEAL L5KEI8_PTEAL TDGF1 TDGF1 SETD2 SETD2 L5KFN4_PTEAL L5KFN4_PTEAL L5KFN7_PTEAL L5KFN7_PTEAL NANOG NANOG MIXL1 MIXL1 L5KGP1_PTEAL L5KGP1_PTEAL AXIN1 AXIN1 EPHA2 EPHA2 L5KK77_PTEAL L5KK77_PTEAL GRB2 GRB2 ITGA2 ITGA2 PRKAR1A PRKAR1A L5KM41_PTEAL L5KM41_PTEAL L5KNC7_PTEAL L5KNC7_PTEAL EXOC4 EXOC4 LRP5 LRP5 MSGN1 MSGN1 L5KRI4_PTEAL L5KRI4_PTEAL WNT3 WNT3 ITGB3 ITGB3 L5KTX5_PTEAL L5KTX5_PTEAL L5KUH4_PTEAL L5KUH4_PTEAL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP15Matrix metalloproteinase-15. (315 aa)
L5KVM5_PTEALIntegrin alpha-7; Belongs to the integrin alpha chain family. (1204 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (741 aa)
MEGF8Multiple epidermal growth factor-like domains 8. (2790 aa)
DVL1Segment polarity protein dishevelled like protein DVL-1. (699 aa)
TLX2T-cell leukemia homeobox protein 2. (284 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1039 aa)
PAF1RNA polymerase II-associated factor 1 like protein. (537 aa)
L5L4T5_PTEALMerlin. (662 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (808 aa)
CTR9RNA polymerase-associated protein CTR9 like protein. (1161 aa)
L5L3V4_PTEALEomesodermin like protein. (285 aa)
DUSP1Dual specificity protein phosphatase 1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (225 aa)
HAND1Heart-and neural crest derivatives-expressed protein 1. (253 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
L5L1M8_PTEALTranscription factor SOX-7. (356 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
FN1Fibronectin. (2477 aa)
L5L187_PTEALDual specificity protein phosphatase 1. (154 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
L5L0D8_PTEALNephrocystin-3. (1152 aa)
CUL3Cullin-3; Belongs to the cullin family. (743 aa)
L5L000_PTEALIntegrin alpha-8; Belongs to the integrin alpha chain family. (931 aa)
EXT2Exostosin-2. (1849 aa)
TBX19T-box transcription factor TBX19. (269 aa)
L5KXJ7_PTEALLaminin subunit beta-3. (1197 aa)
RNF2E3 ubiquitin-protein ligase RING2. (336 aa)
AMOTAngiomotin. (1098 aa)
L5KWI4_PTEALHepatocyte nuclear factor 1-alpha. (469 aa)
L5KW93_PTEALMatrix metalloproteinase-15. (271 aa)
COL4A2Collagen alpha-2(IV) chain. (169 aa)
COL12A1Collagen alpha-1(XII) chain. (1132 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
L5JM54_PTEALTeneurin-4. (837 aa)
L5JN10_PTEALCollagen alpha-1(XII) chain. (1667 aa)
LMBRD1Putative lysosomal cobalamin transporter. (522 aa)
L5JNB4_PTEALTeneurin-4. (415 aa)
SRFSerum response factor. (361 aa)
TENM4Teneurin-4. (1516 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (558 aa)
INHBAInhibin beta A chain. (423 aa)
LAMB1Laminin subunit beta-1. (1785 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
FOXF1Forkhead box protein F1. (353 aa)
VTNVitronectin. (462 aa)
ITGA3Integrin alpha-3; Belongs to the integrin alpha chain family. (1051 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (200 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
SYF2Pre-mRNA-splicing factor SYF2. (246 aa)
ZIC3Zinc finger protein ZIC 3. (469 aa)
L5JUZ8_PTEALTranscription factor SOX-17. (341 aa)
L5JV73_PTEALEyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (530 aa)
L5JVY2_PTEALProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (336 aa)
POFUT2GDP-fucose protein O-fucosyltransferase 2. (364 aa)
COL6A1Collagen alpha-1(VI) chain. (504 aa)
L5JXP1_PTEALLysine-specific demethylase 6B. (1574 aa)
L5JY48_PTEALGuanine nucleotide-binding protein subunit beta-2-like 1. (251 aa)
L5JYK8_PTEALCollagen alpha-1(VI) chain. (203 aa)
ARFRP1ADP-ribosylation factor-related protein 1. (201 aa)
L5JZ72_PTEALIntegrin alpha-4; Belongs to the integrin alpha chain family. (914 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (378 aa)
UGDHUDP-glucose 6-dehydrogenase. (546 aa)
L5JZH0_PTEALGlypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (115 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1039 aa)
DVL2Segment polarity protein dishevelled like protein DVL-2. (733 aa)
L5K0K6_PTEALZinc finger protein SNAI1. (354 aa)
OTX2Homeobox protein OTX2. (289 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
DUSP5Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (351 aa)
LDB1LIM domain-binding protein 1. (453 aa)
SMAD3Mothers against decapentaplegic homolog. (460 aa)
LEO1RNA polymerase-associated protein LEO1. (667 aa)
SMAD4Mothers against decapentaplegic homolog. (549 aa)
RTF1RNA polymerase-associated protein RTF1 like protein. (656 aa)
ITGAVIntegrin alpha-V; Belongs to the integrin alpha chain family. (1011 aa)
GATA6Transcription factor GATA-6. (291 aa)
TWSG1Twisted gastrulation protein like protein 1. (223 aa)
PLPP3Lipid phosphate phosphohydrolase 3. (252 aa)
L5K3G8_PTEALMothers against decapentaplegic like protein 3. (136 aa)
L5K3Q7_PTEALLipid phosphate phosphohydrolase 3. (168 aa)
L5K3U3_PTEALRNA polymerase-associated protein LEO1. (191 aa)
LEF1Lymphoid enhancer-binding factor 1. (451 aa)
L5K5E3_PTEALTranscription factor GATA-6. (296 aa)
CRB2Crumbs like protein 2. (771 aa)
TAL1T-cell acute lymphocytic leukemia protein 1. (214 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (346 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (475 aa)
CER1Cerberus. (274 aa)
RIC8ASynembryn-A. (528 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (452 aa)
ATOH8Protein atonal like protein 8. (356 aa)
KDM6ALysine-specific demethylase 6A. (1142 aa)
COL8A1Collagen alpha-1(VIII) chain. (744 aa)
FAM208ADUF3715 domain-containing protein. (1668 aa)
ARMC5Armadillo repeat-containing protein 5. (949 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (412 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
SFRP1Secreted frizzled-related protein 1. (283 aa)
NODALNodal like protein. (347 aa)
L5KDL8_PTEALExostosin-1; Belongs to the glycosyltransferase 47 family. (329 aa)
L5KEI8_PTEALBrachyury protein. (396 aa)
TDGF1Teratocarcinoma-derived growth factor 2. (112 aa)
SETD2Histone-lysine N-methyltransferase SETD2. (2482 aa)
L5KFN4_PTEALEphrin type-A receptor 2. (116 aa)
L5KFN7_PTEALZinc finger and BTB domain-containing protein 17. (832 aa)
NANOGHomeobox protein NANOGP8. (295 aa)
MIXL1Homeobox protein MIXL1. (237 aa)
L5KGP1_PTEALEphrin type-A receptor 2. (255 aa)
AXIN1Axin-1. (867 aa)
EPHA2Receptor protein-tyrosine kinase. (380 aa)
L5KK77_PTEALT-box transcription factor TBX6. (409 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1168 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (381 aa)
L5KM41_PTEALHomeobox protein Hox-A11. (258 aa)
L5KNC7_PTEALIntegrin beta. (1758 aa)
EXOC4Exocyst complex component 4. (505 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1616 aa)
MSGN1Mesogenin-1. (194 aa)
L5KRI4_PTEALExocyst complex component 4. (455 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
ITGB3Integrin beta. (785 aa)
L5KTX5_PTEALCollagen alpha-2(IV) chain. (1604 aa)
L5KUH4_PTEALCollagen alpha-1(VII) chain. (833 aa)
Your Current Organism:
Pteropus alecto
NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox
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