STRINGSTRING
FSHR FSHR L5KWH1_PTEAL L5KWH1_PTEAL CAT CAT F2 F2 ERBB4 ERBB4 SELP SELP L5KZ16_PTEAL L5KZ16_PTEAL L5KZN9_PTEAL L5KZN9_PTEAL PDGFD PDGFD PPARD PPARD UBE3A UBE3A FN1 FN1 L5L3D5_PTEAL L5L3D5_PTEAL L5L3M8_PTEAL L5L3M8_PTEAL L5L458_PTEAL L5L458_PTEAL NTRK3 NTRK3 OSM OSM L5L5C2_PTEAL L5L5C2_PTEAL MYDGF MYDGF L5L639_PTEAL L5L639_PTEAL TREML2 TREML2 SEMA3E SEMA3E HGF HGF L5JPI5_PTEAL L5JPI5_PTEAL SERPINA12 SERPINA12 PIK3AP1 PIK3AP1 L5JS88_PTEAL L5JS88_PTEAL L5JSY8_PTEAL L5JSY8_PTEAL DCN DCN L5JTE2_PTEAL L5JTE2_PTEAL CSF3 CSF3 NTRK1 NTRK1 FGR FGR L5JV60_PTEAL L5JV60_PTEAL IGF1R IGF1R L5JW58_PTEAL L5JW58_PTEAL HAX1 HAX1 KDR KDR SEMA4D SEMA4D CD28 CD28 ROR1 ROR1 AGT AGT NEDD4 NEDD4 NCF1 NCF1 FGF2 FGF2 ARHGAP8 ARHGAP8 L5K9B3_PTEAL L5K9B3_PTEAL PDGFC PDGFC L5K9R7_PTEAL L5K9R7_PTEAL PDGFB PDGFB TGFB2 TGFB2 INSR INSR NTRK2 NTRK2 SIRT1 SIRT1 L5KE87_PTEAL L5KE87_PTEAL GPER1 GPER1 ROR2 ROR2 UNC5B UNC5B PTPN6 PTPN6 IL18 IL18 F2RL1 F2RL1 L5KNA4_PTEAL L5KNA4_PTEAL NKX3-1 NKX3-1 SOX9 SOX9 L5KR12_PTEAL L5KR12_PTEAL L5KR64_PTEAL L5KR64_PTEAL LEP LEP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (643 aa)
L5KWH1_PTEALAngiopoietin-1 receptor. (1379 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
F2Prothrombin; Belongs to the peptidase S1 family. (644 aa)
ERBB4Receptor tyrosine-protein kinase erbB-4. (477 aa)
SELPP-selectin. (158 aa)
L5KZ16_PTEALProtor-2. (337 aa)
L5KZN9_PTEALMyocilin. (444 aa)
PDGFDPlatelet-derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (352 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
UBE3AUbiquitin-protein ligase E3A. (783 aa)
FN1Fibronectin. (2477 aa)
L5L3D5_PTEALTyrosine-protein kinase receptor. (314 aa)
L5L3M8_PTEALNT-3 growth factor receptor. (109 aa)
L5L458_PTEALVascular endothelial growth factor receptor kdr-like protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1013 aa)
NTRK3NT-3 growth factor receptor. (614 aa)
OSMOncostatin-M. (215 aa)
L5L5C2_PTEALNT-3 growth factor receptor. (96 aa)
MYDGFUncharacterized protein. (176 aa)
L5L639_PTEALVascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1247 aa)
TREML2Trem-like transcript 2 protein. (810 aa)
SEMA3ESemaphorin-3E; Belongs to the semaphorin family. (775 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (688 aa)
L5JPI5_PTEALReelin. (2633 aa)
SERPINA12Serpin A12; Belongs to the serpin family. (414 aa)
PIK3AP1Phosphoinositide 3-kinase adapter protein 1. (1000 aa)
L5JS88_PTEALInsulin-like growth factor 1 receptor. (340 aa)
L5JSY8_PTEALReelin. (105 aa)
DCNDecorin; May affect the rate of fibrils formation. (363 aa)
L5JTE2_PTEALInsulin-like growth factor 1 receptor. (289 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
NTRK1High affinity nerve growth factor receptor. (109 aa)
FGRTyrosine-protein kinase. (527 aa)
L5JV60_PTEALSemaphorin-4D; Belongs to the semaphorin family. (554 aa)
IGF1RInsulin-like growth factor 1 receptor. (862 aa)
L5JW58_PTEALHigh affinity nerve growth factor receptor. (627 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1344 aa)
SEMA4DSemaphorin-4D. (380 aa)
CD28T-cell-specific surface glycoprotein CD28. (193 aa)
ROR1Tyrosine-protein kinase transmembrane receptor ROR1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (924 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4. (862 aa)
NCF1Neutrophil cytosol factor 1. (392 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (134 aa)
ARHGAP8Rho GTPase-activating protein 8. (465 aa)
L5K9B3_PTEALProtor-1. (278 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (328 aa)
L5K9R7_PTEALInsulin receptor. (249 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (340 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
INSRTyrosine-protein kinase receptor. (1211 aa)
NTRK2BDNF/NT-3 growth factors receptor. (464 aa)
SIRT1NAD-dependent deacetylase sirtuin-1. (840 aa)
L5KE87_PTEALTyrosine-protein kinase receptor. (356 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
ROR2Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (944 aa)
UNC5BNetrin receptor UNC5B. (948 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (189 aa)
F2RL1Proteinase-activated receptor 2. (420 aa)
L5KNA4_PTEALE3 ubiquitin-protein ligase CBL. (909 aa)
NKX3-1Homeobox protein Nkx-3.1. (238 aa)
SOX9Transcription factor SOX-9. (499 aa)
L5KR12_PTEALInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
L5KR64_PTEALProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (327 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (146 aa)
Your Current Organism:
Pteropus alecto
NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox
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