STRINGSTRING
L5KLC6_PTEAL L5KLC6_PTEAL RFC3 RFC3 RAD21 RAD21 RCBTB2 RCBTB2 GINS4 GINS4 PSMD13 PSMD13 POLE3 POLE3 L5KA29_PTEAL L5KA29_PTEAL PSMD5 PSMD5 CDC26 CDC26 PSMD6 PSMD6 RBX1 RBX1 ANAPC15 ANAPC15 L5K7J3_PTEAL L5K7J3_PTEAL ANAPC2 ANAPC2 SKP2 SKP2 L5K647_PTEAL L5K647_PTEAL MCM7 MCM7 ORC1 ORC1 RFC1 RFC1 L5K369_PTEAL L5K369_PTEAL ESCO1 ESCO1 PSMD4 PSMD4 L5K2J2_PTEAL L5K2J2_PTEAL POLA1 POLA1 PSMA5 PSMA5 L5K287_PTEAL L5K287_PTEAL L5K267_PTEAL L5K267_PTEAL L5K1X4_PTEAL L5K1X4_PTEAL CUL1 CUL1 UBE2C UBE2C L5K158_PTEAL L5K158_PTEAL L5K0R8_PTEAL L5K0R8_PTEAL PSMC6 PSMC6 CDC25B CDC25B L5JZX1_PTEAL L5JZX1_PTEAL PSMB6 PSMB6 ORC4 ORC4 PCNA PCNA L5JZR4_PTEAL L5JZR4_PTEAL PSMA7 PSMA7 PSMD14 PSMD14 MCM6 MCM6 SKP1 SKP1 L5JXN5_PTEAL L5JXN5_PTEAL PSMF1 PSMF1 PDS5A PDS5A MCM8 MCM8 POLE2 POLE2 SMC1A SMC1A CDC23 CDC23 CKS2 CKS2 CCNE1 CCNE1 CKS1B CKS1B RPA1 RPA1 PSMD11 PSMD11 PSMB3 PSMB3 L5JRG6_PTEAL L5JRG6_PTEAL ATAD5 ATAD5 ORC5 ORC5 GINS2 GINS2 PSMA2 PSMA2 L5JQH0_PTEAL L5JQH0_PTEAL L5JQD7_PTEAL L5JQD7_PTEAL CDC6 CDC6 L5KC72_PTEAL L5KC72_PTEAL PSMC1 PSMC1 PSMD3 PSMD3 PSME3 PSME3 RFC4 RFC4 PSMC2 PSMC2 ORC3 ORC3 L5JNL5_PTEAL L5JNL5_PTEAL MCM9 MCM9 PRIM2 PRIM2 CDT1 CDT1 MCM3 MCM3 PSMD12 PSMD12 CCND1 CCND1 PSMC5 PSMC5 POLA2 POLA2 RPA3 RPA3 MCM2 MCM2 CDCA5 CDCA5 POLD2 POLD2 L5KQ81_PTEAL L5KQ81_PTEAL PSMD8 PSMD8 FEN1 FEN1 L5KQL9_PTEAL L5KQL9_PTEAL WEE2 WEE2 POLD4 POLD4 ANAPC5 ANAPC5 L5KSE2_PTEAL L5KSE2_PTEAL L5KSL0_PTEAL L5KSL0_PTEAL CDC27 CDC27 POLE POLE UBC UBC ANAPC7 ANAPC7 PSMD9 PSMD9 PSMB10 PSMB10 L5KUR1_PTEAL L5KUR1_PTEAL PSMD7 PSMD7 RCBTB1 RCBTB1 L5KUY9_PTEAL L5KUY9_PTEAL ANAPC1 ANAPC1 CDK4 CDK4 L5KW55_PTEAL L5KW55_PTEAL PRIM1 PRIM1 L5KWC8_PTEAL L5KWC8_PTEAL CDK2 CDK2 GINS3 GINS3 ORC6 ORC6 RFC5 RFC5 STAG1 STAG1 PSMC3 PSMC3 PSMB8 PSMB8 CDKN1A CDKN1A L5L039_PTEAL L5L039_PTEAL PSMD1 PSMD1 PSMB9 PSMB9 TM4SF19 TM4SF19 WEE1 WEE1 ESCO2 ESCO2 PSMC4 PSMC4 MCM4 MCM4 PSMA4 PSMA4 L5L4M7_PTEAL L5L4M7_PTEAL PSMA1 PSMA1 KXD1 KXD1 POLD1 POLD1 L5L6X9_PTEAL L5L6X9_PTEAL FZR1 FZR1 UBE2S UBE2S STAG2 STAG2 WAPL WAPL ANAPC16 ANAPC16 MNAT1 MNAT1 RB1 RB1 PSMB1 PSMB1 L5KFC9_PTEAL L5KFC9_PTEAL CCNA1 CCNA1 DNA2 DNA2 L5KG21_PTEAL L5KG21_PTEAL L5KHD6_PTEAL L5KHD6_PTEAL L5KHI2_PTEAL L5KHI2_PTEAL L5KHL0_PTEAL L5KHL0_PTEAL MCM5 MCM5 PSMB5 PSMB5 PSMD10 PSMD10 PSMA6 PSMA6 L5KIM2_PTEAL L5KIM2_PTEAL L5KIM6_PTEAL L5KIM6_PTEAL L5KJG1_PTEAL L5KJG1_PTEAL CDKN1B CDKN1B PSME2 PSME2 L5KKY5_PTEAL L5KKY5_PTEAL ANAPC11 ANAPC11 TM7SF3 TM7SF3 PSMB11 PSMB11 CCNH CCNH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
L5KLC6_PTEALCell division protein kinase 3; Belongs to the protein kinase superfamily. (337 aa)
RFC3Replication factor C subunit 3. (356 aa)
RAD21Double-strand-break repair protein rad21 like protein. (631 aa)
RCBTB2RCC1 and BTB domain-containing protein 2. (621 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (244 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
POLE3DNA polymerase epsilon subunit 3. (147 aa)
L5KA29_PTEALCyclin-A2; Belongs to the cyclin family. (333 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5. (504 aa)
CDC26Anaphase-promoting complex subunit CDC26. (85 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6. (389 aa)
RBX1RING-box protein 1. (101 aa)
ANAPC15Protein HSPC020 like protein. (121 aa)
L5K7J3_PTEALAnaphase-promoting complex subunit 4. (533 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (1107 aa)
SKP2S-phase kinase-associated protein 2. (436 aa)
L5K647_PTEALProteasome subunit beta. (314 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (962 aa)
RFC1Replication factor C subunit 1. (1252 aa)
L5K369_PTEALCullin-1; Belongs to the cullin family. (150 aa)
ESCO1N-acetyltransferase ESCO1. (844 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4. (377 aa)
L5K2J2_PTEALStructural maintenance of chromosomes protein. (1229 aa)
POLA1DNA polymerase alpha catalytic subunit. (108 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
L5K287_PTEALProteasome subunit alpha type. (250 aa)
L5K267_PTEALUncharacterized protein. (960 aa)
L5K1X4_PTEALCDK5 and ABL1 enzyme substrate 1. (656 aa)
CUL1Cullin-1; Belongs to the cullin family. (616 aa)
UBE2CUbiquitin-conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
L5K158_PTEALDNA replication complex GINS protein PSF1. (262 aa)
L5K0R8_PTEALDNA polymerase. (1483 aa)
PSMC626S protease regulatory subunit S10B; Belongs to the AAA ATPase family. (403 aa)
CDC25BM-phase inducer phosphatase 2. (574 aa)
L5JZX1_PTEALDouble-strand-break repair protein rad21-like protein 1. (580 aa)
PSMB6Proteasome subunit beta. (239 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
L5JZR4_PTEALOrigin recognition complex subunit 2. (466 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (432 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (224 aa)
L5JXN5_PTEALStructural maintenance of chromosomes protein 1A. (1050 aa)
PSMF1Proteasome inhibitor PI31 subunit. (271 aa)
PDS5ASister chromatid cohesion protein PDS5 like protein A. (1262 aa)
MCM8DNA replication licensing factor MCM8; Belongs to the MCM family. (685 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (535 aa)
SMC1AStructural maintenance of chromosomes protein 1A. (109 aa)
CDC23Cell division cycle protein 23 like protein. (622 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (428 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (599 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (422 aa)
PSMB3Proteasome subunit beta. (234 aa)
L5JRG6_PTEAL26S protease regulatory subunit 4. (112 aa)
ATAD5ATPase family AAA domain-containing protein 5. (1839 aa)
ORC5Origin recognition complex subunit 5. (464 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
L5JQH0_PTEALDNA polymerase delta subunit 3. (409 aa)
L5JQD7_PTEALProteasome subunit beta type-3. (140 aa)
CDC6Cell division control protein 6 like protein. (1003 aa)
L5KC72_PTEALSister chromatid cohesion protein PDS5 like protein B. (1567 aa)
PSMC126S protease regulatory subunit 4; Belongs to the AAA ATPase family. (498 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
PSME3Proteasome activator complex subunit 3. (254 aa)
RFC4Replication factor C subunit 4. (394 aa)
PSMC226S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
ORC3Origin recognition complex subunit 3. (744 aa)
L5JNL5_PTEALCullin-1; Belongs to the cullin family. (99 aa)
MCM9DNA replication licensing factor MCM9; Belongs to the MCM family. (801 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (525 aa)
CDT1DNA replication factor Cdt1. (552 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12. (456 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (296 aa)
PSMC526S protease regulatory subunit 8; Belongs to the AAA ATPase family. (465 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (639 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
MCM2DNA helicase; Belongs to the MCM family. (930 aa)
CDCA5Sororin. (253 aa)
POLD2DNA polymerase delta subunit 2. (469 aa)
L5KQ81_PTEALProtein FAM89B. (179 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (287 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa)
L5KQL9_PTEALCyclin-dependent kinase inhibitor 1C. (101 aa)
WEE2Wee1-like protein kinase 2. (701 aa)
POLD4DNA polymerase delta subunit 4. (107 aa)
ANAPC5Anaphase-promoting complex subunit 5. (779 aa)
L5KSE2_PTEALAnaphase-promoting complex subunit 7. (67 aa)
L5KSL0_PTEALDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1930 aa)
CDC27Cell division cycle protein 27 like protein. (825 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (365 aa)
UBCUbiquitin. (381 aa)
ANAPC7Anaphase-promoting complex subunit 7. (568 aa)
PSMD926S proteasome non-ATPase regulatory subunit 9. (210 aa)
PSMB10Proteasome subunit beta. (271 aa)
L5KUR1_PTEALProteasome activator complex subunit 4. (1456 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (322 aa)
RCBTB1RCC1 and BTB domain-containing protein 1. (531 aa)
L5KUY9_PTEAL26S protease regulatory subunit 6A-A. (96 aa)
ANAPC1Anaphase-promoting complex subunit 1. (1913 aa)
CDK4Cell division protein kinase 4; Belongs to the protein kinase superfamily. (302 aa)
L5KW55_PTEALProteasome subunit alpha type-5. (106 aa)
PRIM1DNA primase small subunit. (1526 aa)
L5KWC8_PTEALUbiquitin. (77 aa)
CDK2Cell division protein kinase 2; Belongs to the protein kinase superfamily. (346 aa)
GINS3DNA replication complex GINS protein PSF3. (207 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
RFC5Replication factor C subunit 5. (345 aa)
STAG1Cohesin subunit SA-1. (1249 aa)
PSMC326S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (439 aa)
PSMB8Proteasome subunit beta. (274 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (226 aa)
L5L039_PTEALSororin. (157 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (908 aa)
PSMB9Proteasome subunit beta. (249 aa)
TM4SF19Transmembrane 4 L6 family member 19. (204 aa)
WEE1Wee1-like protein kinase. (499 aa)
ESCO2N-acetyltransferase ESCO2. (612 aa)
PSMC426S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
MCM4DNA helicase; Belongs to the MCM family. (862 aa)
PSMA4Proteasome subunit alpha type. (287 aa)
L5L4M7_PTEALDNA ligase. (926 aa)
PSMA1Proteasome subunit alpha type. (289 aa)
KXD1KxDL domain-containing protein. (176 aa)
POLD1DNA polymerase. (1109 aa)
L5L6X9_PTEAL60S ribosomal protein L40. (74 aa)
FZR1Fizzy-related protein like protein. (493 aa)
UBE2SUbiquitin-conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (327 aa)
STAG2Cohesin subunit SA-2. (1228 aa)
WAPLWings apart-like protein like protein. (1227 aa)
ANAPC16Uncharacterized protein. (110 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
RB1Retinoblastoma-associated protein. (925 aa)
PSMB1Proteasome subunit beta. (241 aa)
L5KFC9_PTEAL26S proteasome non-ATPase regulatory subunit 4. (100 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (440 aa)
DNA2DNA2-like helicase. (1094 aa)
L5KG21_PTEALDNA replication licensing factor MCM5. (172 aa)
L5KHD6_PTEALM-phase inducer phosphatase 1. (556 aa)
L5KHI2_PTEALUbiquitin-conjugating enzyme E2 S. (159 aa)
L5KHL0_PTEALUncharacterized protein. (343 aa)
MCM5DNA replication licensing factor MCM5; Belongs to the MCM family. (520 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10. (259 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
L5KIM2_PTEAL26S protease regulatory subunit 6B. (384 aa)
L5KIM6_PTEALCell division protein kinase 7. (399 aa)
L5KJG1_PTEALTranscription elongation regulator 1-like protein. (177 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
PSME2Proteasome activator complex subunit 2. (239 aa)
L5KKY5_PTEALProteasome activator complex subunit 1. (260 aa)
ANAPC11Anaphase-promoting complex subunit 11. (84 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
PSMB11Proteasome subunit beta. (299 aa)
CCNHCyclin-H; Belongs to the cyclin family. (324 aa)
Your Current Organism:
Pteropus alecto
NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox
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