STRINGSTRING
VEGFA VEGFA PTEN PTEN HGF HGF FOXO3 FOXO3 ERBB2 ERBB2 NF1 NF1 AKT1 AKT1 RPS6KB1 RPS6KB1 NRG2 NRG2 IGF1R IGF1R KDR KDR IL6R IL6R EIF4E1B EIF4E1B SHC3 SHC3 PLCG1 PLCG1 PDGFRA PDGFRA BCL2L1 BCL2L1 SRC SRC MAP2K1 MAP2K1 NRAS NRAS SHC4 SHC4 L5K6I9_PTEAL L5K6I9_PTEAL RPS6 RPS6 JAK1 JAK1 FGF2 FGF2 RAF1 RAF1 PDGFC PDGFC EIF4EBP1 EIF4EBP1 PDGFB PDGFB IGF1 IGF1 MTOR MTOR MAPK3 MAPK3 AKT3 AKT3 BCL2 BCL2 PRKCB PRKCB GRB2 GRB2 PIK3R1 PIK3R1 HRAS HRAS BAD BAD PIK3CA PIK3CA IL6 IL6 RPS6KB2 RPS6KB2 EGFR EGFR MET MET PLCG2 PLCG2 TGFA TGFA ERBB3 ERBB3 GAS6 GAS6 SOS1 SOS1 PDGFD PDGFD PDGFRB PDGFRB PRKCG PRKCG GAB1 GAB1 BAX BAX PIK3R2 PIK3R2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (190 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (688 aa)
FOXO3Forkhead box protein O3. (479 aa)
ERBB2Receptor tyrosine-protein kinase erbB-2. (797 aa)
NF1Neurofibromin. (2867 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform. (183 aa)
IGF1RInsulin-like growth factor 1 receptor. (862 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1344 aa)
IL6RInterleukin-6 receptor subunit alpha. (385 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (286 aa)
SHC3SHC-transforming protein 3. (470 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1255 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
BCL2L1Bcl-2-like protein 1. (76 aa)
SRCTyrosine-protein kinase. (536 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NRASGTPase NRas. (189 aa)
SHC4SHC-transforming protein 4. (582 aa)
L5K6I9_PTEALPhosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
RPS640S ribosomal protein S6. (325 aa)
JAK1Tyrosine-protein kinase. (1170 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (134 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (642 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (328 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (340 aa)
IGF1Insulin-like growth factor I. (280 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2208 aa)
MAPK3Mitogen-activated protein kinase 3; Belongs to the protein kinase superfamily. (410 aa)
AKT3Non-specific serine/threonine protein kinase. (283 aa)
BCL2Apoptosis regulator Bcl-2. (217 aa)
PRKCBProtein kinase C beta type. (374 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (165 aa)
HRASGTPase HRas. (187 aa)
BADBcl2 antagonist of cell death. (168 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
IL6Interleukin-6. (202 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (478 aa)
EGFREpidermal growth factor receptor. (850 aa)
METHepatocyte growth factor receptor. (998 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
TGFAProtransforming growth factor alpha. (300 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1317 aa)
GAS6Growth arrest-specific protein 6. (640 aa)
SOS1Son of sevenless like protein 1. (1304 aa)
PDGFDPlatelet-derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (352 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1125 aa)
PRKCGNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (487 aa)
GAB1GRB2-associated-binding protein 1. (738 aa)
BAXApoptosis regulator BAX. (194 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (710 aa)
Your Current Organism:
Pteropus alecto
NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox
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