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MAP3K7 MAP3K7 PTEN PTEN ATG2B ATG2B ZFYVE1 ZFYVE1 UVRAG UVRAG MTMR4 MTMR4 BECN1 BECN1 VMP1 VMP1 AKT1 AKT1 TBK1 TBK1 RPS6KB1 RPS6KB1 IGF1R IGF1R RAB7B RAB7B GABARAP GABARAP MAPK9 MAPK9 SQSTM1 SQSTM1 BCL2L1 BCL2L1 RHEB RHEB MAP2K1 MAP2K1 EIF2AK4 EIF2AK4 DAPK2 DAPK2 TANK TANK NRAS NRAS CFLAR CFLAR PRKAA1 PRKAA1 ATG14 ATG14 ATG16L2 ATG16L2 L5K556_PTEAL L5K556_PTEAL PRKAA2 PRKAA2 TSC1 TSC1 L5K6I9_PTEAL L5K6I9_PTEAL PRKACB PRKACB RRAGA RRAGA PRKACA PRKACA VAMP8 VAMP8 RAF1 RAF1 LAMP2 LAMP2 DEPTOR DEPTOR PPP2CB PPP2CB ATG7 ATG7 MTMR14 MTMR14 EIF2S1 EIF2S1 NRBF2 NRBF2 DAPK1 DAPK1 HIF1A HIF1A IRS4 IRS4 MTOR MTOR DDIT4 DDIT4 PDPK1 PDPK1 MAPK3 MAPK3 WDR41 WDR41 AKT3 AKT3 EIF2AK3 EIF2AK3 BCL2 BCL2 BNIP3 BNIP3 PIK3R1 PIK3R1 ATG10 ATG10 HRAS HRAS RPTOR RPTOR WIPI1 WIPI1 BAD BAD ERN1 ERN1 PIK3CA PIK3CA RPS6KB2 RPS6KB2 ATG2A ATG2A STX17 STX17 CTSD CTSD L5KR12_PTEAL L5KR12_PTEAL ULK1 ULK1 CAMKK2 CAMKK2 RAB1A RAB1A LAMP1 LAMP1 IRS2 IRS2 ULK2 ULK2 SNAP29 SNAP29 RAB7A RAB7A GABARAPL2 GABARAPL2 SMCR8 SMCR8 MAPK10 MAPK10 MRAS MRAS PIK3R4 PIK3R4 ATG9A ATG9A L5L198_PTEAL L5L198_PTEAL ATG16L1 ATG16L1 RAB33B RAB33B RUBCN RUBCN IRS1 IRS1 CTSB CTSB GABARAPL1 GABARAPL1 ATG4D ATG4D RAB39B RAB39B RRAS2 RRAS2 RRAS RRAS MTMR3 MTMR3 RAB8A RAB8A ATG101 ATG101 HMGB1 HMGB1 DAPK3 DAPK3 PIK3R2 PIK3R2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ATG2BAutophagy-related protein 2 like protein B. (2078 aa)
ZFYVE1Zinc finger FYVE domain-containing protein 1. (777 aa)
UVRAGUV radiation resistance-associated protein. (698 aa)
MTMR4Myotubularin-related protein 4; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (1644 aa)
BECN1Beclin-1. (470 aa)
VMP1Transmembrane protein 49. (453 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
IGF1RInsulin-like growth factor 1 receptor. (862 aa)
RAB7BRas-related protein Rab-7b. (236 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
MAPK9Mitogen-activated protein kinase 9. (209 aa)
SQSTM1Sequestosome-1. (64 aa)
BCL2L1Bcl-2-like protein 1. (76 aa)
RHEBGTP-binding protein Rheb. (238 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
EIF2AK4Eukaryotic translation initiation factor 2-alpha kinase 4. (1642 aa)
DAPK2Death-associated protein kinase 3. (476 aa)
TANKTRAF family member-associated NF-kappa-B activator. (425 aa)
NRASGTPase NRas. (189 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (482 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ATG14Uncharacterized protein. (505 aa)
ATG16L2Autophagy-related protein 16-2. (622 aa)
L5K556_PTEALCathepsin L1; Belongs to the peptidase C1 family. (331 aa)
PRKAA2Non-specific serine/threonine protein kinase. (462 aa)
TSC1Hamartin. (75 aa)
L5K6I9_PTEALPhosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (336 aa)
RRAGARas-related GTP-binding protein A. (291 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (346 aa)
VAMP8Vesicle-associated membrane protein 8. (100 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (642 aa)
LAMP2Lysosome-associated membrane glycoprotein 2. (456 aa)
DEPTORDEP domain-containing mTOR-interacting protein. (405 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (743 aa)
MTMR14Myotubularin-related protein 14. (649 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (295 aa)
NRBF2Nuclear receptor-binding factor 2. (251 aa)
DAPK1Death-associated protein kinase 1. (668 aa)
HIF1AHypoxia-inducible factor 1 alpha. (873 aa)
IRS4Insulin receptor substrate 4. (1154 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2208 aa)
DDIT4DNA-damage-inducible transcript 4 protein. (230 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (563 aa)
MAPK3Mitogen-activated protein kinase 3; Belongs to the protein kinase superfamily. (410 aa)
WDR41WD repeat-containing protein 41. (457 aa)
AKT3Non-specific serine/threonine protein kinase. (283 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (1148 aa)
BCL2Apoptosis regulator Bcl-2. (217 aa)
BNIP3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (253 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (165 aa)
ATG10Autophagy-related protein 10. (242 aa)
HRASGTPase HRas. (187 aa)
RPTORRegulatory-associated protein of mTOR. (1335 aa)
WIPI1WD repeat domain phosphoinositide-interacting protein 1. (437 aa)
BADBcl2 antagonist of cell death. (168 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (944 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (478 aa)
ATG2AAutophagy-related protein 2 like protein A. (998 aa)
STX17Syntaxin-17; Belongs to the syntaxin family. (311 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (375 aa)
L5KR12_PTEALInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ULK1Serine/threonine-protein kinase ULK1. (1072 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2. (561 aa)
RAB1ARas-related protein Rab-1A. (197 aa)
LAMP1Lysosome-associated membrane glycoprotein 1. (380 aa)
IRS2Insulin receptor substrate 2. (367 aa)
ULK2Serine/threonine-protein kinase ULK2. (1641 aa)
SNAP29Synaptosomal-associated protein 29. (258 aa)
RAB7ARas-related protein Rab-7a. (207 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa)
SMCR8Smith-Magenis syndrome chromosomal region candidate protein 8 protein. (937 aa)
MAPK10Mitogen-activated protein kinase 10. (146 aa)
MRASRas-related protein M-Ras. (188 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1380 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (810 aa)
L5L198_PTEALCathepsin L1; Belongs to the peptidase C1 family. (334 aa)
ATG16L1Autophagy-related protein 16-1. (608 aa)
RAB33BRas-related protein Rab-33B. (229 aa)
RUBCNRUN domain-containing protein. (1016 aa)
IRS1Insulin receptor substrate 1. (1238 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (359 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (117 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (442 aa)
RAB39BRas-related protein Rab-39B. (213 aa)
RRAS2Ras-related protein R-Ras2. (258 aa)
RRASRas-related protein R-Ras. (191 aa)
MTMR3Myotubularin-related protein 3. (1194 aa)
RAB8ARas-related protein Rab-8A. (207 aa)
ATG101Autophagy-related protein 101. (218 aa)
HMGB1High mobility group protein B1. (215 aa)
DAPK3Death-associated protein kinase 3. (505 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (710 aa)
Your Current Organism:
Pteropus alecto
NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox
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