STRINGSTRING
CHMP2B CHMP2B SNX3 SNX3 HSPA8 HSPA8 SMAP1 SMAP1 ARRB1 ARRB1 RAB11FIP4 RAB11FIP4 AP2M1 AP2M1 ZFYVE27 ZFYVE27 VPS25 VPS25 GIT1 GIT1 MDM2 MDM2 CDC42 CDC42 CAPZB CAPZB ARFGEF1 ARFGEF1 SNF8 SNF8 EPN3 EPN3 ARAP3 ARAP3 IQSEC3 IQSEC3 SMURF1 SMURF1 GRK6 GRK6 IQSEC2 IQSEC2 LDLRAP1 LDLRAP1 CLTB CLTB ASAP3 ASAP3 IGF1R IGF1R FGFR4 FGFR4 WASHC1 WASHC1 EEA1 EEA1 RABEP1 RABEP1 GIT2 GIT2 L5JXD8_PTEAL L5JXD8_PTEAL CHMP1A CHMP1A ARRB2 ARRB2 RUFY1 RUFY1 ARF1 ARF1 PML PML PDGFRA PDGFRA PSD PSD CHMP4B CHMP4B RAB11FIP2 RAB11FIP2 RAB11A RAB11A SRC SRC GBF1 GBF1 SMAD3 SMAD3 ARFGEF2 ARFGEF2 AGAP3 AGAP3 ARFGAP1 ARFGAP1 STAM2 STAM2 DAB2 DAB2 ARF6 ARF6 CAPZA1 CAPZA1 ZFYVE9 ZFYVE9 NEDD4 NEDD4 DNAJC6 DNAJC6 EHD4 EHD4 ARAP2 ARAP2 SH3GL2 SH3GL2 EPS15 EPS15 MVB12B MVB12B VPS45 VPS45 SH3GLB2 SH3GLB2 PIP5K1A PIP5K1A GRK4 GRK4 ARPC5L ARPC5L VPS37D VPS37D IQSEC1 IQSEC1 ARFGAP3 ARFGAP3 FOLR2 FOLR2 PIP5KL1 PIP5KL1 RAB11B RAB11B L5K9Z8_PTEAL L5K9Z8_PTEAL ARF4 ARF4 PSD3 PSD3 L5KBE5_PTEAL L5KBE5_PTEAL RAB11FIP1 RAB11FIP1 CHMP5 CHMP5 SPART SPART WASHC5 WASHC5 VPS37A VPS37A HSPA2 HSPA2 VPS26A VPS26A VTA1 VTA1 WASHC4 WASHC4 IGF2R IGF2R KIF5B KIF5B CYTH4 CYTH4 RAB11FIP3 RAB11FIP3 L5KHA6_PTEAL L5KHA6_PTEAL IL2RB IL2RB SNX6 SNX6 WASHC3 WASHC3 ZFYVE16 ZFYVE16 SNX2 SNX2 ARPC1A ARPC1A NEDD4L NEDD4L VPS28 VPS28 VPS4B VPS4B HGS HGS ASAP1 ASAP1 CBLC CBLC CHMP7 CHMP7 HRAS HRAS SMURF2 SMURF2 TGFBR1 TGFBR1 CYTH1 CYTH1 VPS37C VPS37C CLTA CLTA PLD1 PLD1 AP2A2 AP2A2 PARD3 PARD3 SH3KBP1 SH3KBP1 EGFR EGFR EHD1 EHD1 GRK2 GRK2 PRKCI PRKCI CAV2 CAV2 ARF5 ARF5 EHD3 EHD3 VPS37B VPS37B WASL WASL CAV1 CAV1 PARD6A PARD6A AGAP1 AGAP1 CAPZA2 CAPZA2 IST1 IST1 ASAP2 ASAP2 GRK1 GRK1 PSD4 PSD4 VPS36 VPS36 RAB5B RAB5B VPS35 VPS35 CLTCL1 CLTCL1 RHOA RHOA RAB7A RAB7A KIF5A KIF5A EPN2 EPN2 TSG101 TSG101 ARFGAP2 ARFGAP2 RAB5A RAB5A RBSN RBSN STAM STAM GRK7 GRK7 IZUMO1R IZUMO1R L5L1S3_PTEAL L5L1S3_PTEAL DNM2 DNM2 VPS26B VPS26B ACAP2 ACAP2 LDLR LDLR STAMBP STAMBP TGFBR2 TGFBR2 AP2A1 AP2A1 PDCD6IP PDCD6IP SH3GL3 SH3GL3 L5L5M6_PTEAL L5L5M6_PTEAL RAB8A RAB8A CYTH2 CYTH2 EHD2 EHD2 HSPA1B HSPA1B CHMP2A CHMP2A SH3GL1 SH3GL1 EPS15L1 EPS15L1 SMAP2 SMAP2 L5L7B6_PTEAL L5L7B6_PTEAL PRKCZ PRKCZ L5L7M4_PTEAL L5L7M4_PTEAL PIP5K1C PIP5K1C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHMP2BCharged multivesicular body protein 2b. (202 aa)
SNX3Sorting nexin-3. (162 aa)
HSPA8Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. (643 aa)
SMAP1Stromal membrane-associated protein 1. (469 aa)
ARRB1Beta-arrestin-1. (413 aa)
RAB11FIP4Rab11 family-interacting protein 4. (497 aa)
AP2M1AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family. (433 aa)
ZFYVE27Zinc finger FYVE domain-containing protein 27. (404 aa)
VPS25Vacuolar protein-sorting-associated protein 25. (176 aa)
GIT1ARF GTPase-activating protein GIT1. (793 aa)
MDM2E3 ubiquitin-protein ligase Mdm2. (431 aa)
CDC42Cell division control protein 42 like protein. (295 aa)
CAPZBF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (256 aa)
ARFGEF1Brefeldin A-inhibited guanine nucleotide-exchange protein 1. (1909 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
EPN3Epsin-3. (257 aa)
ARAP3Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3. (1513 aa)
IQSEC3IQ motif and SEC7 domain-containing protein 3. (1309 aa)
SMURF1E3 ubiquitin-protein ligase SMURF1. (718 aa)
GRK6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (576 aa)
IQSEC2IQ motif and SEC7 domain-containing protein 2. (1325 aa)
LDLRAP1Low density lipoprotein receptor adapter protein 1. (264 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (155 aa)
ASAP3Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3. (873 aa)
IGF1RInsulin-like growth factor 1 receptor. (862 aa)
FGFR4Fibroblast growth factor receptor. (820 aa)
WASHC1WAS protein family like protein 1. (559 aa)
EEA1Early endosome antigen 1. (1447 aa)
RABEP1Rab GTPase-binding effector protein 1. (937 aa)
GIT2ARF GTPase-activating protein GIT2. (748 aa)
L5JXD8_PTEALClass I histocompatibility antigen, GOGO-C0101/C0102 alpha chain; Belongs to the MHC class I family. (362 aa)
CHMP1ACharged multivesicular body protein 1a. (417 aa)
ARRB2Beta-arrestin-2. (409 aa)
RUFY1RUN and FYVE domain-containing protein 1. (732 aa)
ARF1ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
PMLPutative transcription factor PML. (877 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
PSDPH and SEC7 domain-containing protein 1. (754 aa)
CHMP4BCharged multivesicular body protein 4b. (224 aa)
RAB11FIP2Rab11 family-interacting protein 2. (512 aa)
RAB11ARas-related protein Rab-11A. (216 aa)
SRCTyrosine-protein kinase. (536 aa)
GBF1Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1. (1850 aa)
SMAD3Mothers against decapentaplegic homolog. (460 aa)
ARFGEF2Brefeldin A-inhibited guanine nucleotide-exchange protein 2. (1777 aa)
AGAP3Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3. (840 aa)
ARFGAP1ADP-ribosylation factor GTPase-activating protein 1. (536 aa)
STAM2Signal transducing adapter molecule 2. (495 aa)
DAB2Disabled like protein 2. (733 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
CAPZA1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1338 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4. (862 aa)
DNAJC6Putative tyrosine-protein phosphatase auxilin. (995 aa)
EHD4EH domain-containing protein 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (541 aa)
ARAP2Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2. (1767 aa)
SH3GL2Endophilin-A1. (357 aa)
EPS15Epidermal growth factor receptor substrate 15. (1196 aa)
MVB12BMultivesicular body subunit 12B. (261 aa)
VPS45Vacuolar protein sorting-associated protein 45; Belongs to the STXBP/unc-18/SEC1 family. (570 aa)
SH3GLB2Endophilin-B2. (395 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type-1 alpha. (582 aa)
GRK4G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (545 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (101 aa)
VPS37DVacuolar protein sorting-associated protein 37D. (175 aa)
IQSEC1IQ motif and SEC7 domain-containing protein 1. (1184 aa)
ARFGAP3ADP-ribosylation factor GTPase-activating protein 3. (1062 aa)
FOLR2Folate receptor beta. (253 aa)
PIP5KL1Phosphatidylinositol-4-phosphate 5-kinase-like protein 1. (397 aa)
RAB11BRas-related protein Rab-11B. (226 aa)
L5K9Z8_PTEALProtein FAM21A. (1358 aa)
ARF4ADP-ribosylation factor 4; Belongs to the small GTPase superfamily. Arf family. (279 aa)
PSD3PH and SEC7 domain-containing protein 3. (635 aa)
L5KBE5_PTEALCharged multivesicular body protein 1b-2. (241 aa)
RAB11FIP1Rab11 family-interacting protein 1. (1251 aa)
CHMP5Charged multivesicular body protein 5. (219 aa)
SPARTSpartin. (651 aa)
WASHC5Strumpellin. (206 aa)
VPS37AVacuolar protein sorting-associated protein 37A. (383 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (607 aa)
VPS26AVacuolar protein sorting-associated protein 26A. (360 aa)
VTA1Vacuolar protein sorting-associated protein VTA1 like protein. (306 aa)
WASHC4UPF0681 protein KIAA1033. (1172 aa)
IGF2RCation-independent mannose-6-phosphate receptor. (2471 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
CYTH4Cytohesin-4. (416 aa)
RAB11FIP3Rab11 family-interacting protein 3. (542 aa)
L5KHA6_PTEALC-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
IL2RBInterleukin-2 receptor subunit beta. (532 aa)
SNX6Sorting nexin; Involved in several stages of intracellular trafficking. (412 aa)
WASHC3Coiled-coil domain-containing protein 53. (274 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1505 aa)
SNX2Sorting nexin-2. (519 aa)
ARPC1AActin-related protein 2/3 complex subunit 1A. (789 aa)
NEDD4LE3 ubiquitin-protein ligase NEDD4-like protein. (922 aa)
VPS28Vacuolar protein sorting-associated protein 28 like protein; Belongs to the VPS28 family. (167 aa)
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (455 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (590 aa)
ASAP1Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1. (946 aa)
CBLCSignal transduction protein CBL-C. (451 aa)
CHMP7Charged multivesicular body protein 7. (450 aa)
HRASGTPase HRas. (187 aa)
SMURF2E3 ubiquitin-protein ligase. (735 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (400 aa)
CYTH1Cytohesin-1. (415 aa)
VPS37CVacuolar protein sorting-associated protein 37C. (353 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (218 aa)
PLD1Phospholipase. (1149 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (913 aa)
PARD3Partitioning defective 3 like protein. (1076 aa)
SH3KBP1SH3 domain-containing kinase-binding protein 1. (720 aa)
EGFREpidermal growth factor receptor. (850 aa)
EHD1EH domain-containing protein 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (534 aa)
GRK2Beta-adrenergic receptor kinase 1. (1209 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
ARF5ADP-ribosylation factor 5; Belongs to the small GTPase superfamily. Arf family. (180 aa)
EHD3EH domain-containing protein 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
VPS37BVacuolar protein sorting-associated protein 37B. (227 aa)
WASLNeural Wiskott-Aldrich syndrome protein. (501 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
PARD6APartitioning defective 6 like protein alpha. (266 aa)
AGAP1Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1. (348 aa)
CAPZA2F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
IST1IST1 like protein. (364 aa)
ASAP2Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2. (1129 aa)
GRK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (564 aa)
PSD4PH and SEC7 domain-containing protein 4. (313 aa)
VPS36Vacuolar protein-sorting-associated protein 36. (389 aa)
RAB5BRas-related protein Rab-5B. (256 aa)
VPS35Vacuolar protein sorting-associated protein 35. (524 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1669 aa)
RHOATransforming protein RhoA. (265 aa)
RAB7ARas-related protein Rab-7a. (207 aa)
KIF5AKinesin heavy chain isoform 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1032 aa)
EPN2Epsin-2. (200 aa)
TSG101Tumor susceptibility protein 101 protein. (391 aa)
ARFGAP2ADP-ribosylation factor GTPase-activating protein 2. (520 aa)
RAB5ARas-related protein Rab-5A. (215 aa)
RBSNRabenosyn-5. (782 aa)
STAMSignal transducing adapter molecule 1. (599 aa)
GRK7G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (579 aa)
IZUMO1RPutative folate receptor delta. (237 aa)
L5L1S3_PTEALHigh affinity interleukin-8 receptor B; Belongs to the G-protein coupled receptor 1 family. (317 aa)
DNM2Dynamin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (839 aa)
VPS26BVacuolar protein sorting-associated protein 26B. (336 aa)
ACAP2Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2. (813 aa)
LDLRLow-density lipoprotein receptor. (881 aa)
STAMBPSTAM-binding protein. (446 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (947 aa)
PDCD6IPProgrammed cell death 6-interacting protein. (862 aa)
SH3GL3Endophilin-A3. (278 aa)
L5L5M6_PTEALHeat shock 70 kDa protein 1; Belongs to the heat shock protein 70 family. (640 aa)
RAB8ARas-related protein Rab-8A. (207 aa)
CYTH2Cytohesin-2. (383 aa)
EHD2EH domain-containing protein 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (537 aa)
HSPA1BHeat shock 70 kDa protein 1; Belongs to the heat shock protein 70 family. (641 aa)
CHMP2ACharged multivesicular body protein 2a. (229 aa)
SH3GL1Endophilin-A2. (333 aa)
EPS15L1Epidermal growth factor receptor substrate 15-like 1. (929 aa)
SMAP2Stromal membrane-associated protein 2. (429 aa)
L5L7B6_PTEALHeat shock 70 kDa protein 1L; Belongs to the heat shock protein 70 family. (641 aa)
PRKCZNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (392 aa)
L5L7M4_PTEALCHLA class I histocompatibility antigen, A-5 alpha chain. (101 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type-1 gamma. (758 aa)
Your Current Organism:
Pteropus alecto
NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox
Server load: low (12%) [HD]