STRINGSTRING
WNT11 WNT11 FZD4 FZD4 SLC7A5 SLC7A5 PTEN PTEN DVL3 DVL3 CHUK CHUK FZD1 FZD1 AKT1 AKT1 SESN2 SESN2 L5JT49_PTEAL L5JT49_PTEAL WNT5B WNT5B ATP6V1H ATP6V1H RPS6KB1 RPS6KB1 RPS6KA1 RPS6KA1 WNT4 WNT4 LAMTOR2 LAMTOR2 FNIP1 FNIP1 IGF1R IGF1R ATP6V1E1 ATP6V1E1 EIF4E1B EIF4E1B WNT9A WNT9A LPIN3 LPIN3 TTI1 TTI1 FZD7 FZD7 DVL2 DVL2 RHEB RHEB MAP2K1 MAP2K1 LPIN2 LPIN2 FZD5 FZD5 NRAS NRAS WNT2B WNT2B PRKAA1 PRKAA1 LAMTOR5 LAMTOR5 RICTOR RICTOR PRKAA2 PRKAA2 FZD9 FZD9 SKP2 SKP2 TSC1 TSC1 L5K6I9_PTEAL L5K6I9_PTEAL RPS6 RPS6 MAPKAP1 MAPKAP1 WNT7A WNT7A LAMTOR4 LAMTOR4 RRAGA RRAGA WNT7B WNT7B LAMTOR1 LAMTOR1 RAF1 RAF1 ATP6V1G1 ATP6V1G1 FNIP2 FNIP2 WNT1 WNT1 DEPTOR DEPTOR WNT10B WNT10B ATP6V1C1 ATP6V1C1 WNT5A WNT5A EIF4EBP1 EIF4EBP1 SEC13 SEC13 IKBKB IKBKB CAB39L CAB39L INSR INSR FZD6 FZD6 RPS6KA2 RPS6KA2 IGF1 IGF1 TNFRSF1A TNFRSF1A MTOR MTOR DDIT4 DDIT4 TELO2 TELO2 WDR24 WDR24 L5KGQ7_PTEAL L5KGQ7_PTEAL PDPK1 PDPK1 MAPK3 MAPK3 ATP6V1D ATP6V1D RNF152 RNF152 AKT3 AKT3 NPRL3 NPRL3 LRP6 LRP6 PRKCB PRKCB GRB2 GRB2 PIK3R1 PIK3R1 STRADA STRADA GRB10 GRB10 HRAS HRAS RPTOR RPTOR SLC3A2 SLC3A2 PIK3CA PIK3CA RPS6KB2 RPS6KB2 RPS6KA3 RPS6KA3 L5KR12_PTEAL L5KR12_PTEAL LRP5 LRP5 ATP6V1F ATP6V1F ULK1 ULK1 FZD10 FZD10 WNT3 WNT3 WNT2 WNT2 LPIN1 LPIN1 CLIP1 CLIP1 FZD2 FZD2 ATP6V1E2 ATP6V1E2 SEH1L SEH1L ATP6V1B1 ATP6V1B1 NPRL2 NPRL2 L5KUW4_PTEAL L5KUW4_PTEAL SOS1 SOS1 RHOA RHOA ULK2 ULK2 FLCN FLCN WDR59 WDR59 PRKCG PRKCG WNT10A WNT10A IRS1 IRS1 WNT6 WNT6 FZD3 FZD3 TNF TNF CASTOR1 CASTOR1 ATP6V1B2 ATP6V1B2 PIK3R2 PIK3R2 DVL1 DVL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (479 aa)
SLC7A5Large neutral amino acids transporter small subunit 1. (72 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
DVL3Segment polarity protein dishevelled like protein DVL-3. (288 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (655 aa)
FZD1Frizzled-1. (190 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SESN2Sestrin-2. (480 aa)
L5JT49_PTEALProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (218 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (443 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RPS6KA1Ribosomal protein S6 kinase. (743 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
LAMTOR2Mitogen-activated protein-binding protein-interacting protein. (125 aa)
FNIP1Folliculin-interacting protein 1. (1138 aa)
IGF1RInsulin-like growth factor 1 receptor. (862 aa)
ATP6V1E1V-type proton ATPase subunit E 1. (226 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (286 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
LPIN3Lipin-3. (846 aa)
TTI1Uncharacterized protein. (1092 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
DVL2Segment polarity protein dishevelled like protein DVL-2. (733 aa)
RHEBGTP-binding protein Rheb. (238 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
LPIN2Lipin-2. (897 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
NRASGTPase NRas. (189 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
LAMTOR5Hepatitis B virus X-interacting protein like protein. (91 aa)
RICTORRapamycin-insensitive companion of mTOR. (1707 aa)
PRKAA2Non-specific serine/threonine protein kinase. (462 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (546 aa)
SKP2S-phase kinase-associated protein 2. (436 aa)
TSC1Hamartin. (75 aa)
L5K6I9_PTEALPhosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
RPS640S ribosomal protein S6. (325 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1. (522 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (174 aa)
LAMTOR4Uncharacterized protein. (99 aa)
RRAGARas-related GTP-binding protein A. (291 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
LAMTOR1Uncharacterized protein. (161 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (642 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
FNIP2Folliculin-interacting protein 2. (320 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
DEPTORDEP domain-containing mTOR-interacting protein. (405 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (661 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
SEC13Protein SEC13 like protein; Belongs to the WD repeat SEC13 family. (432 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (770 aa)
CAB39LCalcium-binding protein 39-like protein. (370 aa)
INSRTyrosine-protein kinase receptor. (1211 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (682 aa)
RPS6KA2Ribosomal protein S6 kinase. (730 aa)
IGF1Insulin-like growth factor I. (280 aa)
TNFRSF1AAmiloride-sensitive sodium channel subunit alpha; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (998 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2208 aa)
DDIT4DNA-damage-inducible transcript 4 protein. (230 aa)
TELO2Telomere length regulation protein TEL2 like protein. (783 aa)
WDR24WD repeat-containing protein 24. (789 aa)
L5KGQ7_PTEALNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (563 aa)
MAPK3Mitogen-activated protein kinase 3; Belongs to the protein kinase superfamily. (410 aa)
ATP6V1DV-type proton ATPase subunit D. (247 aa)
RNF152RING finger protein 152. (203 aa)
AKT3Non-specific serine/threonine protein kinase. (283 aa)
NPRL3Uncharacterized protein. (570 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
PRKCBProtein kinase C beta type. (374 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (165 aa)
STRADASTE20-related kinase adapter protein alpha. (404 aa)
GRB10Growth factor receptor-bound protein 10. (509 aa)
HRASGTPase HRas. (187 aa)
RPTORRegulatory-associated protein of mTOR. (1335 aa)
SLC3A24F2 cell-surface antigen heavy chain. (526 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (478 aa)
RPS6KA3Ribosomal protein S6 kinase alpha-3. (700 aa)
L5KR12_PTEALInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1616 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
ULK1Serine/threonine-protein kinase ULK1. (1072 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
LPIN1Lipin-1. (928 aa)
CLIP1CAP-Gly domain-containing linker protein 1. (431 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (509 aa)
ATP6V1E2V-type proton ATPase subunit E 2. (226 aa)
SEH1LNucleoporin SEH1; Belongs to the WD repeat SEC13 family. (427 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
NPRL2Tumor suppressor candidate 4. (380 aa)
L5KUW4_PTEALTBC1 domain family member 7. (293 aa)
SOS1Son of sevenless like protein 1. (1304 aa)
RHOATransforming protein RhoA. (265 aa)
ULK2Serine/threonine-protein kinase ULK2. (1641 aa)
FLCNFolliculin. (582 aa)
WDR59WD repeat-containing protein 59. (968 aa)
PRKCGNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (487 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
IRS1Insulin receptor substrate 1. (1238 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (148 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CASTOR1GATS-like protein 3. (329 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (506 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (710 aa)
DVL1Segment polarity protein dishevelled like protein DVL-1. (699 aa)
Your Current Organism:
Pteropus alecto
NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox
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