STRINGSTRING
MAP3K7 MAP3K7 MLYCD MLYCD PPP2R5C PPP2R5C FOXO3 FOXO3 ADIPOQ ADIPOQ SCD SCD ACACA ACACA AKT1 AKT1 RAB2A RAB2A RPS6KB1 RPS6KB1 IGF1R IGF1R ADIPOR2 ADIPOR2 SLC2A4 SLC2A4 CRTC2 CRTC2 PPP2R2B PPP2R2B HNF4A HNF4A PFKFB2 PFKFB2 G6PC2 G6PC2 PCK1 PCK1 PFKL PFKL ACACB ACACB RHEB RHEB CREB1 CREB1 PRKAG2 PRKAG2 PRKAB2 PRKAB2 PRKAA1 PRKAA1 PPARGC1A PPARGC1A FBP2 FBP2 PRKAA2 PRKAA2 TSC1 TSC1 L5K6I9_PTEAL L5K6I9_PTEAL TBC1D1 TBC1D1 CPT1B CPT1B PPP2R2C PPP2R2C RAB11B RAB11B PFKP PFKP EIF4EBP1 EIF4EBP1 PPP2CB PPP2CB PPP2R3B PPP2R3B CAB39L CAB39L RAB14 RAB14 INSR INSR ADRA1A ADRA1A SIRT1 SIRT1 PFKM PFKM PPP2R5E PPP2R5E CREB3 CREB3 IGF1 IGF1 CCNA1 CCNA1 IRS4 IRS4 MTOR MTOR PDPK1 PDPK1 AKT3 AKT3 PCK2 PCK2 EEF2K EEF2K FASN FASN HMGCR HMGCR PPP2R3C PPP2R3C PIK3R1 PIK3R1 STRADA STRADA PPP2R1B PPP2R1B CREB5 CREB5 RPTOR RPTOR CCND1 CCND1 PPP2R5B PPP2R5B PIK3CA PIK3CA RPS6KB2 RPS6KB2 CREB3L2 CREB3L2 CPT1A CPT1A L5KR12_PTEAL L5KR12_PTEAL LEP LEP ULK1 ULK1 CAMKK2 CAMKK2 G6PC3 G6PC3 IRS2 IRS2 FOXO1 FOXO1 ADIPOR1 ADIPOR1 CREB3L1 CREB3L1 PRKAB1 PRKAB1 SREBF1 SREBF1 PPP2R5A PPP2R5A PPP2R3A PPP2R3A SCD5 SCD5 PRKAG3 PRKAG3 PFKFB3 PFKFB3 IRS1 IRS1 CPT1C CPT1C PPP2R1A PPP2R1A GYS1 GYS1 RAB8A RAB8A LIPE LIPE PIK3R2 PIK3R2 EEF2 EEF2 CREB3L3 CREB3L3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MLYCDMalonyl-CoA decarboxylase, mitochondrial. (497 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa)
FOXO3Forkhead box protein O3. (479 aa)
ADIPOQAdiponectin. (244 aa)
SCDAcyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
ACACAAcetyl-CoA carboxylase 1. (2530 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RAB2ARas-related protein Rab-2A. (224 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
IGF1RInsulin-like growth factor 1 receptor. (862 aa)
ADIPOR2Adiponectin receptor protein 2. (386 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (534 aa)
CRTC2CREB-regulated transcription coactivator 2. (650 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (446 aa)
HNF4AHepatocyte nuclear factor 4-alpha. (484 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 2. (483 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (630 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (751 aa)
ACACBAcetyl-CoA carboxylase 2. (1312 aa)
RHEBGTP-binding protein Rheb. (238 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (341 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (251 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (244 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (792 aa)
FBP2Fructose-1,6-bisphosphatase isozyme 2; Belongs to the FBPase class 1 family. (339 aa)
PRKAA2Non-specific serine/threonine protein kinase. (462 aa)
TSC1Hamartin. (75 aa)
L5K6I9_PTEALPhosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
TBC1D1TBC1 domain family member 1. (1225 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform. (1214 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (358 aa)
RAB11BRas-related protein Rab-11B. (226 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (791 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PPP2R3BSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta. (578 aa)
CAB39LCalcium-binding protein 39-like protein. (370 aa)
RAB14Ras-related protein Rab-14. (215 aa)
INSRTyrosine-protein kinase receptor. (1211 aa)
ADRA1AAlpha-1A adrenergic receptor. (466 aa)
SIRT1NAD-dependent deacetylase sirtuin-1. (840 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (817 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (376 aa)
IGF1Insulin-like growth factor I. (280 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (440 aa)
IRS4Insulin receptor substrate 4. (1154 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2208 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (563 aa)
AKT3Non-specific serine/threonine protein kinase. (283 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (666 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
FASNFatty acid synthase. (2442 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (881 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma. (453 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (165 aa)
STRADASTE20-related kinase adapter protein alpha. (404 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (992 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (483 aa)
RPTORRegulatory-associated protein of mTOR. (1335 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (296 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (478 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
CPT1ACarnitine O-palmitoyltransferase 1, liver isoform. (877 aa)
L5KR12_PTEALInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (146 aa)
ULK1Serine/threonine-protein kinase ULK1. (1072 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2. (561 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
IRS2Insulin receptor substrate 2. (367 aa)
FOXO1Forkhead box protein O1. (578 aa)
ADIPOR1Adiponectin receptor protein 1. (299 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
SREBF1Sterol regulatory element-binding protein 1. (1125 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha. (1111 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (295 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (504 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3. (566 aa)
IRS1Insulin receptor substrate 1. (1238 aa)
CPT1CCarnitine O-palmitoyltransferase 1, brain isoform; Belongs to the carnitine/choline acetyltransferase family. (802 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (2470 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (738 aa)
RAB8ARas-related protein Rab-8A. (207 aa)
LIPEHormone-sensitive lipase. (769 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (710 aa)
EEF2Elongation factor 2. (846 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (446 aa)
Your Current Organism:
Pteropus alecto
NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox
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