STRINGSTRING
HDAC2 HDAC2 FOXO3 FOXO3 HSPA8 HSPA8 HDAC1 HDAC1 AKT1 AKT1 RPS6KB1 RPS6KB1 IGF1R IGF1R FOXA2 FOXA2 PRKAG2 PRKAG2 NRAS NRAS PRKAB2 PRKAB2 PRKAA1 PRKAA1 CLPB CLPB PRKAA2 PRKAA2 L5K6I9_PTEAL L5K6I9_PTEAL PRKACB PRKACB PRKACA PRKACA INSR INSR ADCY6 ADCY6 ADCY2 ADCY2 SIRT1 SIRT1 HSPA2 HSPA2 SOD2 SOD2 IGF1 IGF1 EIF4EBP2 EIF4EBP2 IRS4 IRS4 MTOR MTOR ADCY9 ADCY9 AKT3 AKT3 ADCY4 ADCY4 CRYAB CRYAB PIK3R1 PIK3R1 ADCY8 ADCY8 ADCY1 ADCY1 HRAS HRAS RPTOR RPTOR PIK3CA PIK3CA RPS6KB2 RPS6KB2 L5KR12_PTEAL L5KR12_PTEAL ADCY3 ADCY3 ADCY7 ADCY7 IRS2 IRS2 FOXO1 FOXO1 L5KWR8_PTEAL L5KWR8_PTEAL CAT CAT PRKAB1 PRKAB1 SOD1 SOD1 PRKAG3 PRKAG3 IRS1 IRS1 L5L5M6_PTEAL L5L5M6_PTEAL HSPA1B HSPA1B L5L7B6_PTEAL L5L7B6_PTEAL PIK3R2 PIK3R2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (479 aa)
FOXO3Forkhead box protein O3. (479 aa)
HSPA8Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. (643 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
IGF1RInsulin-like growth factor 1 receptor. (862 aa)
FOXA2Hepatocyte nuclear factor 3-beta. (457 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (251 aa)
NRASGTPase NRas. (189 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (244 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
CLPBCaseinolytic peptidase B protein like protein. (425 aa)
PRKAA2Non-specific serine/threonine protein kinase. (462 aa)
L5K6I9_PTEALPhosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (336 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (346 aa)
INSRTyrosine-protein kinase receptor. (1211 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1173 aa)
ADCY2Adenylate cyclase type 2. (165 aa)
SIRT1NAD-dependent deacetylase sirtuin-1. (840 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (607 aa)
SOD2Superoxide dismutase [Mn], mitochondrial. (352 aa)
IGF1Insulin-like growth factor I. (280 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E-binding protein 2. (131 aa)
IRS4Insulin receptor substrate 4. (1154 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2208 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (831 aa)
AKT3Non-specific serine/threonine protein kinase. (283 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1041 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (235 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (165 aa)
ADCY8Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (746 aa)
ADCY1Adenylate cyclase type 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (298 aa)
HRASGTPase HRas. (187 aa)
RPTORRegulatory-associated protein of mTOR. (1335 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (478 aa)
L5KR12_PTEALInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADCY3Adenylate cyclase type 3. (234 aa)
ADCY7Adenylate cyclase type 7. (338 aa)
IRS2Insulin receptor substrate 2. (367 aa)
FOXO1Forkhead box protein O1. (578 aa)
L5KWR8_PTEALSuperoxide dismutase [Cu-Zn]. (124 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (504 aa)
IRS1Insulin receptor substrate 1. (1238 aa)
L5L5M6_PTEALHeat shock 70 kDa protein 1; Belongs to the heat shock protein 70 family. (640 aa)
HSPA1BHeat shock 70 kDa protein 1; Belongs to the heat shock protein 70 family. (641 aa)
L5L7B6_PTEALHeat shock 70 kDa protein 1L; Belongs to the heat shock protein 70 family. (641 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (710 aa)
Your Current Organism:
Pteropus alecto
NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox
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