STRINGSTRING
CHRD CHRD INHBA INHBA NOG NOG NBL1 NBL1 ID3 ID3 BAMBI BAMBI RGMA RGMA GREM2 GREM2 DCN DCN RPS6KB1 RPS6KB1 SMURF1 SMURF1 SMAD5 SMAD5 THSD4 THSD4 FMOD FMOD ID1 ID1 RBL1 RBL1 TGIF2 TGIF2 SKP1 SKP1 BMP2 BMP2 NEO1 NEO1 BMPR2 BMPR2 ACVR1C ACVR1C GDF5 GDF5 BMP4 BMP4 BMP7 BMP7 SMAD3 SMAD3 ACVR2A ACVR2A CUL1 CUL1 FBN1 FBN1 SMAD4 SMAD4 SMAD6 SMAD6 INHBB INHBB SMAD7 SMAD7 ACVR1 ACVR1 ROCK1 ROCK1 GREM1 GREM1 HAMP HAMP ZFYVE9 ZFYVE9 PITX2 PITX2 THBS1 THBS1 MYC MYC RBX1 RBX1 PPP2CB PPP2CB TGFB2 TGFB2 EP300 EP300 GDF6 GDF6 BMPR1A BMPR1A NODAL NODAL SMAD9 SMAD9 MAPK3 MAPK3 ZFYVE16 ZFYVE16 RGMB RGMB PPP2R1B PPP2R1B FST FST SMURF2 SMURF2 TGFBR1 TGFBR1 RPS6KB2 RPS6KB2 ACVR2B ACVR2B ID2 ID2 TGFB1 TGFB1 LTBP1 LTBP1 E2F4 E2F4 INHBE INHBE RHOA RHOA BMP6 BMP6 INHBC INHBC SMAD1 SMAD1 TGFBR2 TGFBR2 PPP2R1A PPP2R1A TNF TNF AMHR2 AMHR2 ACVR1B ACVR1B AMH AMH SP1 SP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHRDChordin. (862 aa)
INHBAInhibin beta A chain. (423 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1. (183 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
RGMARepulsive guidance molecule A. (428 aa)
GREM2Gremlin. (168 aa)
DCNDecorin; May affect the rate of fibrils formation. (363 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
SMURF1E3 ubiquitin-protein ligase SMURF1. (718 aa)
SMAD5Mothers against decapentaplegic homolog. (462 aa)
THSD4Thrombospondin type-1 domain-containing protein 4. (568 aa)
FMODFibromodulin. (376 aa)
ID1DNA-binding protein inhibitor ID-1. (154 aa)
RBL1Retinoblastoma-like protein 1. (1053 aa)
TGIF2Homeobox protein TGIF2. (237 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (224 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
NEO1Neogenin. (1380 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1039 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (443 aa)
GDF5Growth/differentiation factor 5. (478 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SMAD3Mothers against decapentaplegic homolog. (460 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (495 aa)
CUL1Cullin-1; Belongs to the cullin family. (616 aa)
FBN1Fibrillin-1. (2660 aa)
SMAD4Mothers against decapentaplegic homolog. (549 aa)
SMAD6Mothers against decapentaplegic homolog. (737 aa)
INHBBInhibin beta B chain. (320 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (493 aa)
ROCK1Rho-associated protein kinase 1; Belongs to the peptidase C19 family. (1791 aa)
GREM1Gremlin. (184 aa)
HAMPHepcidin. (82 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1338 aa)
PITX2Homeobox protein. (325 aa)
THBS1Thrombospondin-1. (1195 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (440 aa)
RBX1RING-box protein 1. (101 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
EP300Histone acetyltransferase p300. (2385 aa)
GDF6Growth/differentiation factor 6. (459 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
NODALNodal like protein. (347 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
MAPK3Mitogen-activated protein kinase 3; Belongs to the protein kinase superfamily. (410 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1505 aa)
RGMBRGM domain family member B. (453 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (992 aa)
FSTFollistatin. (344 aa)
SMURF2E3 ubiquitin-protein ligase. (735 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (400 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (478 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (496 aa)
ID2DNA-binding protein inhibitor ID-2. (184 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
LTBP1Latent-transforming growth factor beta-binding protein 1. (1210 aa)
E2F4Transcription factor E2F4. (415 aa)
INHBEInhibin beta E chain. (351 aa)
RHOATransforming protein RhoA. (265 aa)
BMP6Bone morphogenetic protein 6. (223 aa)
INHBCInhibin beta C chain. (351 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (2470 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (548 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (453 aa)
AMHMuellerian-inhibiting factor. (401 aa)
SP1Transcription factor Sp1. (781 aa)
Your Current Organism:
Pteropus alecto
NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox
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