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GJA1 GJA1 L5JV49_PTEAL L5JV49_PTEAL TUBA8 TUBA8 L5JZ46_PTEAL L5JZ46_PTEAL PDGFRA PDGFRA PLCB1 PLCB1 TUBB1 TUBB1 ADRB1 ADRB1 SRC SRC MAP2K1 MAP2K1 GJD2 GJD2 GNAI3 GNAI3 NRAS NRAS L5K6T8_PTEAL L5K6T8_PTEAL PRKACB PRKACB TUBB4B TUBB4B PRKACA PRKACA RAF1 RAF1 PDGFC PDGFC GUCY1A1 GUCY1A1 PDGFB PDGFB GUCY1B1 GUCY1B1 HTR2A HTR2A L5KCA6_PTEAL L5KCA6_PTEAL ADCY6 ADCY6 ADCY2 ADCY2 HTR2C HTR2C ADCY9 ADCY9 MAPK3 MAPK3 MAP3K2 MAP3K2 DRD2 DRD2 TUBB TUBB ADCY4 ADCY4 ITPR2 ITPR2 PRKCB PRKCB GRB2 GRB2 ADCY8 ADCY8 ADCY1 ADCY1 CSNK1D CSNK1D HRAS HRAS EGFR EGFR PLCB3 PLCB3 ADCY3 ADCY3 L5KUC9_PTEAL L5KUC9_PTEAL GNAI2 GNAI2 ADCY7 ADCY7 SOS1 SOS1 MAPK7 MAPK7 L5KXM7_PTEAL L5KXM7_PTEAL ITPR3 ITPR3 GUCY1A2 GUCY1A2 PDGFD PDGFD PDGFRB PDGFRB PRKCG PRKCG L5L171_PTEAL L5L171_PTEAL DRD1 DRD1 LPAR1 LPAR1 GNA11 GNA11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
L5JV49_PTEALMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (325 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (482 aa)
L5JZ46_PTEALGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (614 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
PLCB11-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1. (130 aa)
TUBB1Tubulin beta-1 chain; Belongs to the tubulin family. (586 aa)
ADRB1Beta-1 adrenergic receptor. (460 aa)
SRCTyrosine-protein kinase. (536 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GJD2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (321 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
NRASGTPase NRas. (189 aa)
L5K6T8_PTEALGuanine nucleotide-binding protein G(Q) subunit alpha. (235 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (336 aa)
TUBB4BTubulin beta-2C chain; Belongs to the tubulin family. (608 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (346 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (642 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (328 aa)
GUCY1A1Guanylate cyclase soluble subunit alpha-3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (340 aa)
GUCY1B1Guanylate cyclase soluble subunit beta-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (636 aa)
HTR2A5-hydroxytryptamine receptor 2A. (438 aa)
L5KCA6_PTEALTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (479 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1173 aa)
ADCY2Adenylate cyclase type 2. (165 aa)
HTR2C5-hydroxytryptamine receptor 2C; Belongs to the G-protein coupled receptor 1 family. (348 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (831 aa)
MAPK3Mitogen-activated protein kinase 3; Belongs to the protein kinase superfamily. (410 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (855 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (327 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1041 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (3308 aa)
PRKCBProtein kinase C beta type. (374 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
ADCY8Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (746 aa)
ADCY1Adenylate cyclase type 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (298 aa)
CSNK1DCasein kinase I isoform delta. (394 aa)
HRASGTPase HRas. (187 aa)
EGFREpidermal growth factor receptor. (850 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1229 aa)
ADCY3Adenylate cyclase type 3. (234 aa)
L5KUC9_PTEALTubulin beta-2A chain. (107 aa)
GNAI2Guanine nucleotide-binding protein G(I), alpha-2 subunit. (157 aa)
ADCY7Adenylate cyclase type 7. (338 aa)
SOS1Son of sevenless like protein 1. (1304 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (809 aa)
L5KXM7_PTEALTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (457 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2677 aa)
GUCY1A2Guanylate cyclase soluble subunit alpha-2. (257 aa)
PDGFDPlatelet-derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (352 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1125 aa)
PRKCGNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (487 aa)
L5L171_PTEALTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (464 aa)
DRD1D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (445 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (346 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (301 aa)
Your Current Organism:
Pteropus alecto
NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox
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