(38 nodes) Long-term depression network (Pteropus alecto)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CRH	Corticoliberin. (196 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	IGF1R	Insulin-like growth factor 1 receptor. (862 aa)
	L5JZ46_PTEAL	Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas. (614 aa)
	PLCB1	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1. (130 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	PLA2G4F	Phospholipase A2. (842 aa)
	GNAI3	Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
	NRAS	GTPase NRas. (189 aa)
	CACNA1A	Voltage-dependent P/Q-type calcium channel subunit alpha-1A. (108 aa)
	L5K6T8_PTEAL	Guanine nucleotide-binding protein G(Q) subunit alpha. (235 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase. (642 aa)
	GUCY1A1	Guanylate cyclase soluble subunit alpha-3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (309 aa)
	GUCY1B1	Guanylate cyclase soluble subunit beta-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (636 aa)
	GNA12	Guanine nucleotide-binding protein subunit alpha-12. (338 aa)
	IGF1	Insulin-like growth factor I. (280 aa)
	MAPK3	Mitogen-activated protein kinase 3; Belongs to the protein kinase superfamily. (410 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (3308 aa)
	PRKCB	Protein kinase C beta type. (374 aa)
	GNA13	Guanine nucleotide-binding protein subunit alpha-13. (377 aa)
	PPP2R1B	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (992 aa)
	RYR1	Ryanodine receptor 1. (2942 aa)
	HRAS	GTPase HRas. (187 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1229 aa)
	GRID2	Glutamate receptor delta-2 subunit; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (525 aa)
	CRHR1	Corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family. (382 aa)
	GNAI2	Guanine nucleotide-binding protein G(I), alpha-2 subunit. (157 aa)
	GNAZ	Guanine nucleotide-binding protein G(Z) subunit alpha. (355 aa)
	GNAO1	Guanine nucleotide-binding protein G(O) subunit alpha. (111 aa)
	NOS1	Nitric oxide synthase, brain. (1466 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2677 aa)
	PLA2G4A	Phospholipase A2. (737 aa)
	GUCY1A2	Guanylate cyclase soluble subunit alpha-2. (257 aa)
	PRKCG	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (487 aa)
	GRIA1	Glutamate receptor 1. (827 aa)
	PPP2R1A	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (2470 aa)
	GNA11	Guanine nucleotide-binding protein subunit alpha-11. (301 aa)

Your Current Organism:

Pteropus alecto

NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACNA1A	GNAI2	L5K5U8	L5KUM4	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	Guanine nucleotide-binding protein G(I), alpha-2 subunit.	0.903
CACNA1A	GNAI3	L5K5U8	L5K2F9	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	Guanine nucleotide-binding protein G(K) subunit alpha.	0.903
CACNA1A	GNAO1	L5K5U8	L5KW58	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	Guanine nucleotide-binding protein G(O) subunit alpha.	0.909
CACNA1A	GRIA1	L5K5U8	L5L1I9	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	Glutamate receptor 1.	0.468
CACNA1A	PRKCB	L5K5U8	L5KKL7	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	Protein kinase C beta type.	0.905
CACNA1A	PRKCG	L5K5U8	L5L0J5	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.912
CACNA1A	RYR1	L5K5U8	L5KMH7	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	Ryanodine receptor 1.	0.916
CRH	CRHR1	L5JTK0	L5KS17	Corticoliberin.	Corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family.	0.999
CRH	L5JZ46_PTEAL	L5JTK0	L5JZ46	Corticoliberin.	Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas.	0.452
CRHR1	CRH	L5KS17	L5JTK0	Corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family.	Corticoliberin.	0.999
CRHR1	GNA11	L5KS17	L5L8H9	Corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family.	Guanine nucleotide-binding protein subunit alpha-11.	0.454
CRHR1	GNA12	L5KS17	L5KCB5	Corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family.	Guanine nucleotide-binding protein subunit alpha-12.	0.925
CRHR1	GNA13	L5KS17	L5KLN4	Corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family.	Guanine nucleotide-binding protein subunit alpha-13.	0.925
CRHR1	GNAI2	L5KS17	L5KUM4	Corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family.	Guanine nucleotide-binding protein G(I), alpha-2 subunit.	0.937
CRHR1	GNAI3	L5KS17	L5K2F9	Corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family.	Guanine nucleotide-binding protein G(K) subunit alpha.	0.937
CRHR1	GNAO1	L5KS17	L5KW58	Corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family.	Guanine nucleotide-binding protein G(O) subunit alpha.	0.933
CRHR1	GNAZ	L5KS17	L5KVY9	Corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family.	Guanine nucleotide-binding protein G(Z) subunit alpha.	0.929
CRHR1	L5JZ46_PTEAL	L5KS17	L5JZ46	Corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family.	Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas.	0.946
CRHR1	L5K6T8_PTEAL	L5KS17	L5K6T8	Corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family.	Guanine nucleotide-binding protein G(Q) subunit alpha.	0.454
GNA11	CRHR1	L5L8H9	L5KS17	Guanine nucleotide-binding protein subunit alpha-11.	Corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family.	0.454