52 items (Pteropus alecto) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HTR1B	5-hydroxytryptamine receptor 1B. (390 aa)
	HTR1E	5-hydroxytryptamine receptor 1E. (365 aa)
	PKD2L1	Polycystic kidney disease 2-like 1 protein. (718 aa)
	GNAT3	Guanine nucleotide-binding protein G(T) subunit alpha-3. (354 aa)
	ASIC2	Amiloride-sensitive cation channel 1, neuronal; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (233 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2001 aa)
	HTR1D	5-hydroxytryptamine receptor 1D. (400 aa)
	HCN4	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4. (966 aa)
	GABRA2	Gamma-aminobutyric acid receptor subunit alpha-2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (534 aa)
	SCN3A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1930 aa)
	PDE1A	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; Belongs to the cyclic nucleotide phosphodiesterase family. (383 aa)
	PLCB1	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1. (130 aa)
	SCN9A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1964 aa)
	CHRM3	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
	CALHM1	Calcium homeostasis modulator protein 1. (343 aa)
	L5K1L9_PTEAL	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1961 aa)
	CACNA1A	Voltage-dependent P/Q-type calcium channel subunit alpha-1A. (108 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (336 aa)
	ENTPD2	Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family. (495 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (346 aa)
	ADCY6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1173 aa)
	TAS1R2	Taste receptor type 1 member 2. (839 aa)
	GNB3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
	GNG13	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
	GABBR1	Gamma-aminobutyric acid type B receptor subunit 1. (865 aa)
	TAS1R1	Taste receptor type 1 member 1. (222 aa)
	ADCY4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1041 aa)
	HTR3A	5-hydroxytryptamine receptor 3A; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (483 aa)
	SCNN1B	Amiloride-sensitive sodium channel subunit beta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (638 aa)
	ADCY8	Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (746 aa)
	PDE1C	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C. (296 aa)
	GABBR2	Gamma-aminobutyric acid type B receptor subunit 2. (131 aa)
	TAS2R39	Taste receptor type 2. (319 aa)
	TAS2R5	Taste receptor type 2. (298 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1229 aa)
	TAS2R41	Taste receptor type 2. (308 aa)
	TAS2R38	Taste receptor type 2. (335 aa)
	TAS2R4	Taste receptor type 2. (299 aa)
	TAS2R3	Taste receptor type 2. (316 aa)
	TAS2R40	Taste receptor type 2. (318 aa)
	TAS2R16	Taste receptor type 2. (291 aa)
	PKD1L3	Polycystic kidney disease protein 1-like 3. (1927 aa)
	P2RY4	p2Y purinoceptor 4; Belongs to the G-protein coupled receptor 1 family. (365 aa)
	P2RY1	p2Y purinoceptor 1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2677 aa)
	GRM4	Metabotropic glutamate receptor 4. (925 aa)
	TAS2R7	Taste receptor type 2. (312 aa)
	GABRA1	Gamma-aminobutyric acid receptor subunit alpha-1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
	P2RX3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (408 aa)
	GABRA3	Gamma-aminobutyric acid receptor subunit alpha-3. (204 aa)
	PDE1B	Phosphodiesterase. (538 aa)
	TAS1R3	Taste receptor type 1 member 3. (815 aa)

Your Current Organism:

Pteropus alecto

NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY4	ADCY6	L5KK98	L5KCC0	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.964
ADCY4	ADCY8	L5KK98	L5KM43	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.939
ADCY4	ENTPD2	L5KK98	L5K7T7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family.	0.904
ADCY4	GNAT3	L5KK98	L5JNM1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(T) subunit alpha-3.	0.525
ADCY4	GNB3	L5KK98	L5KGH6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3.	0.814
ADCY4	GNG13	L5KK98	L5KGN2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13.	0.811
ADCY4	PDE1A	L5KK98	L5JZJ1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; Belongs to the cyclic nucleotide phosphodiesterase family.	0.663
ADCY4	PDE1B	L5KK98	L5L7E2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.663
ADCY4	PDE1C	L5KK98	L5KMU9	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C.	0.663
ADCY4	PLCB3	L5KK98	L5KQC2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.479
ADCY4	PRKACA	L5KK98	L5K8D3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.939
ADCY4	PRKACB	L5KK98	L5K737	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily.	0.939
ADCY6	ADCY4	L5KCC0	L5KK98	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.964
ADCY6	ADCY8	L5KCC0	L5KM43	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.935
ADCY6	ENTPD2	L5KCC0	L5K7T7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family.	0.901
ADCY6	GNAT3	L5KCC0	L5JNM1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(T) subunit alpha-3.	0.525
ADCY6	GNB3	L5KCC0	L5KGH6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3.	0.814
ADCY6	GNG13	L5KCC0	L5KGN2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13.	0.810
ADCY6	PDE1A	L5KCC0	L5JZJ1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; Belongs to the cyclic nucleotide phosphodiesterase family.	0.668
ADCY6	PDE1B	L5KCC0	L5L7E2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.952