(43 nodes) Endometrial cancer network (Pteropus alecto)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	FOXO3	Forkhead box protein O3. (479 aa)
	ERBB2	Receptor tyrosine-protein kinase erbB-2. (797 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	GADD45G	Growth arrest and DNA-damage-inducible protein GADD45 gamma. (159 aa)
	CTNNA1	Catenin alpha-1. (906 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (378 aa)
	TCF7L2	Transcription factor 7-like 2. (399 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	NRAS	GTPase NRas. (189 aa)
	GADD45A	Growth arrest and DNA-damage-inducible protein GADD45 alpha. (165 aa)
	LEF1	Lymphoid enhancer-binding factor 1. (451 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (440 aa)
	L5K6I9_PTEAL	Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase. (642 aa)
	TCF7L1	Transcription factor 7-like 1. (497 aa)
	ILK	Integrin-linked protein kinase. (452 aa)
	CTNNA3	Catenin alpha-3. (267 aa)
	PDPK1	3-phosphoinositide-dependent protein kinase 1. (563 aa)
	AXIN1	Axin-1. (867 aa)
	MAPK3	Mitogen-activated protein kinase 3; Belongs to the protein kinase superfamily. (410 aa)
	POLK	DNA polymerase kappa. (868 aa)
	AKT3	Non-specific serine/threonine protein kinase. (283 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	APC	Uncharacterized protein. (2861 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha. (165 aa)
	AXIN2	Axin-2. (783 aa)
	HRAS	GTPase HRas. (187 aa)
	CCND1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (296 aa)
	BAD	Bcl2 antagonist of cell death. (168 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	EGFR	Epidermal growth factor receptor. (850 aa)
	CDH1	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (638 aa)
	SOS1	Son of sevenless like protein 1. (1304 aa)
	DDB2	DNA damage-binding protein 2. (427 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1. (226 aa)
	ELK1	ETS domain-containing protein Elk-1. (476 aa)
	BAK1	Putative Bcl-2 like protein antagonist/killer 2. (211 aa)
	MLH1	DNA mismatch repair protein Mlh1. (786 aa)
	CTNNA2	Catenin alpha-2. (327 aa)
	BAX	Apoptosis regulator BAX. (194 aa)
	GADD45B	Growth arrest and DNA-damage-inducible protein GADD45 beta. (160 aa)
	PIK3R2	Phosphatidylinositol 3-kinase regulatory subunit beta. (710 aa)

Your Current Organism:

Pteropus alecto

NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT3	L5JSS5	L5KIL4	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.901
AKT1	BAD	L5JSS5	L5KNS7	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Bcl2 antagonist of cell death.	0.947
AKT1	CDKN1A	L5JSS5	L5KZY1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase inhibitor 1.	0.955
AKT1	FOXO3	L5JSS5	L5JPD6	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box protein O3.	0.961
AKT1	ILK	L5JSS5	L5KCS2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Integrin-linked protein kinase.	0.943
AKT1	L5K6I9_PTEAL	L5JSS5	L5K6I9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 3-kinase regulatory subunit gamma.	0.941
AKT1	MAPK3	L5JSS5	L5KH92	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase 3; Belongs to the protein kinase superfamily.	0.928
AKT1	PDPK1	L5JSS5	L5KGR0	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide-dependent protein kinase 1.	0.986
AKT1	PIK3CA	L5JSS5	L5KPB2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.961
AKT1	PIK3R1	L5JSS5	L5KLH8	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 3-kinase regulatory subunit alpha.	0.948
AKT1	PIK3R2	L5JSS5	L5L7Z2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.947
AKT1	PTEN	L5JSS5	L5JNG2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.657
AKT1	RAF1	L5JSS5	L5K8R7	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	RAF proto-oncogene serine/threonine-protein kinase.	0.929
AKT1	TP53	L5JSS5	L5JZ91	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.942
AKT3	AKT1	L5KIL4	L5JSS5	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.901
AKT3	BAD	L5KIL4	L5KNS7	Non-specific serine/threonine protein kinase.	Bcl2 antagonist of cell death.	0.947
AKT3	CDKN1A	L5KIL4	L5KZY1	Non-specific serine/threonine protein kinase.	Cyclin-dependent kinase inhibitor 1.	0.955
AKT3	FOXO3	L5KIL4	L5JPD6	Non-specific serine/threonine protein kinase.	Forkhead box protein O3.	0.961
AKT3	ILK	L5KIL4	L5KCS2	Non-specific serine/threonine protein kinase.	Integrin-linked protein kinase.	0.943
AKT3	L5K6I9_PTEAL	L5KIL4	L5K6I9	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit gamma.	0.941