STRINGSTRING
HSP90AB1 HSP90AB1 PTEN PTEN ETV5 ETV5 CHUK CHUK ERBB2 ERBB2 HSP90AA1 HSP90AA1 AKT1 AKT1 MDM2 MDM2 E2F2 E2F2 CCNE1 CCNE1 ZEB1 ZEB1 IGF1R IGF1R INSRR INSRR MMP9 MMP9 TP53 TP53 PDGFRA PDGFRA TCF7L2 TCF7L2 CREB1 CREB1 E2F1 E2F1 IL1R2 IL1R2 MAP2K1 MAP2K1 NRAS NRAS SPINT1 SPINT1 LEF1 LEF1 L5K6I9_PTEAL L5K6I9_PTEAL NFKB1 NFKB1 RAF1 RAF1 PDGFC PDGFC TCF7L1 TCF7L1 IKBKB IKBKB ATF4 ATF4 PDGFB PDGFB EP300 EP300 PLAU PLAU PLAT PLAT CREB3 CREB3 RB1 RB1 IGF1 IGF1 MTOR MTOR PDPK1 PDPK1 MAPK3 MAPK3 NFKBIA NFKBIA HSP90B1 HSP90B1 AKT3 AKT3 BCL2 BCL2 CDKN1B CDKN1B GRB2 GRB2 PIK3R1 PIK3R1 CREB5 CREB5 HRAS HRAS CCND1 CCND1 NKX3-1 NKX3-1 RELA RELA BAD BAD PIK3CA PIK3CA EGFR EGFR CREB3L2 CREB3L2 L5KQQ7_PTEAL L5KQQ7_PTEAL L5KR12_PTEAL L5KR12_PTEAL SRD5A2 SRD5A2 TGFA TGFA E2F3 E2F3 SOS1 SOS1 FOXO1 FOXO1 CDK2 CDK2 CREB3L1 CREB3L1 L5KXU4_PTEAL L5KXU4_PTEAL PDGFD PDGFD CDKN1A CDKN1A PDGFRB PDGFRB IKBKG IKBKG PIK3R2 PIK3R2 CREB3L3 CREB3L3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HSP90AB1Heat shock protein HSP 90-beta. (733 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ETV5ETS translocation variant 5. (515 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (655 aa)
ERBB2Receptor tyrosine-protein kinase erbB-2. (797 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (731 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MDM2E3 ubiquitin-protein ligase Mdm2. (431 aa)
E2F2Transcription factor E2F2. (437 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (428 aa)
ZEB1Zinc finger E-box-binding homeobox 1. (1063 aa)
IGF1RInsulin-like growth factor 1 receptor. (862 aa)
INSRRInsulin receptor-related protein. (205 aa)
MMP9Matrix metalloproteinase-9. (704 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (378 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
TCF7L2Transcription factor 7-like 2. (399 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (341 aa)
E2F1Transcription factor E2F1. (373 aa)
IL1R2Interleukin-1 receptor type II. (439 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NRASGTPase NRas. (189 aa)
SPINT1Kunitz-type protease inhibitor 1. (513 aa)
LEF1Lymphoid enhancer-binding factor 1. (451 aa)
L5K6I9_PTEALPhosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (933 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (642 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (328 aa)
TCF7L1Transcription factor 7-like 1. (497 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (770 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (340 aa)
EP300Histone acetyltransferase p300. (2385 aa)
PLAUUrokinase-type plasminogen activator. (433 aa)
PLATTissue-type plasminogen activator. (582 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (376 aa)
RB1Retinoblastoma-associated protein. (925 aa)
IGF1Insulin-like growth factor I. (280 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2208 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (563 aa)
MAPK3Mitogen-activated protein kinase 3; Belongs to the protein kinase superfamily. (410 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
HSP90B1Endoplasmin. (680 aa)
AKT3Non-specific serine/threonine protein kinase. (283 aa)
BCL2Apoptosis regulator Bcl-2. (217 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (165 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (483 aa)
HRASGTPase HRas. (187 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (296 aa)
NKX3-1Homeobox protein Nkx-3.1. (238 aa)
RELATranscription factor p65. (533 aa)
BADBcl2 antagonist of cell death. (168 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
EGFREpidermal growth factor receptor. (850 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
L5KQQ7_PTEALGlutathione S-transferase P; Belongs to the GST superfamily. (152 aa)
L5KR12_PTEALInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase 2. (110 aa)
TGFAProtransforming growth factor alpha. (300 aa)
E2F3Transcription factor E2F3. (363 aa)
SOS1Son of sevenless like protein 1. (1304 aa)
FOXO1Forkhead box protein O1. (578 aa)
CDK2Cell division protein kinase 2; Belongs to the protein kinase superfamily. (346 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (519 aa)
L5KXU4_PTEALAndrogen receptor. (195 aa)
PDGFDPlatelet-derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (352 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (226 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1125 aa)
IKBKGNF-kappa-B essential modulator. (394 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (710 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (446 aa)
Your Current Organism:
Pteropus alecto
NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox
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