STRINGSTRING
gltX gltX EYM_00285 EYM_00285 EYM_00290 EYM_00290 EYM_00420 EYM_00420 EYM_00425 EYM_00425 EYM_00450 EYM_00450 sucC sucC sucD sucD EYM_00740 EYM_00740 EYM_00780 EYM_00780 fbp fbp EYM_01085 EYM_01085 EYM_01130 EYM_01130 EYM_01330 EYM_01330 EYM_01350 EYM_01350 EYM_01640 EYM_01640 EYM_02335 EYM_02335 EYM_02600 EYM_02600 pgk pgk EYM_02645 EYM_02645 EYM_02670 EYM_02670 EYM_02770 EYM_02770 EYM_02850 EYM_02850 thrB thrB EYM_03425 EYM_03425 EYM_03450 EYM_03450 EYM_03590 EYM_03590 EYM_03645 EYM_03645 EYM_03730 EYM_03730 gap gap EYM_03975 EYM_03975 EYM_03995 EYM_03995 EYM_04015 EYM_04015 EYM_04020 EYM_04020 EYM_04025 EYM_04025 EYM_04030 EYM_04030 EYM_04445 EYM_04445 eno eno EYM_04520 EYM_04520 EYM_04610 EYM_04610 hemA hemA EYM_04745 EYM_04745 EYM_04795 EYM_04795 EYM_04800 EYM_04800 EYM_04805 EYM_04805 EYM_04810 EYM_04810 EYM_04935 EYM_04935 sdhA sdhA EYM_05450 EYM_05450 EYM_05455 EYM_05455 EYM_05570 EYM_05570 glyA glyA EYM_06195 EYM_06195 EYM_06325 EYM_06325 EYM_06430 EYM_06430 EYM_06730 EYM_06730 EYM_06735 EYM_06735 EYM_06895 EYM_06895 acsA acsA EYM_06970 EYM_06970 EYM_07050 EYM_07050 prs prs EYM_07200 EYM_07200 apgM apgM hemC hemC hemL hemL EYM_07315 EYM_07315 EYM_07420 EYM_07420 tpiA tpiA EYM_07615 EYM_07615 EYM_07630 EYM_07630 EYM_07790 EYM_07790 EYM_07860 EYM_07860
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (568 aa)
EYM_00285Hyaluronate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa)
EYM_00290Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (647 aa)
EYM_00420Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
EYM_00425acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
EYM_004504-hydroxybutyryl-CoA dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (507 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (377 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa)
EYM_00740Acetylornithine deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
EYM_007804Fe-4S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
fbpFructose-1 6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (391 aa)
EYM_01085Phosphoglucomutase; Catalyzes the interconversion of alpha-D-mannose 1-phosphate to alpha-D-mannose 6-phosphate and alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphohexose mutase family. (457 aa)
EYM_01130Iron-sulfur cluster assembly protein HesB; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa)
EYM_01330Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (262 aa)
EYM_01350Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (355 aa)
EYM_01640Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (426 aa)
EYM_02335Aldehyde:ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (630 aa)
EYM_02600Ribose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
pgkPhosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (410 aa)
EYM_02645phenylacetate-CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
EYM_02670Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
EYM_02770Glucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
EYM_02850Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (217 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (312 aa)
EYM_03425Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (488 aa)
EYM_03450Siroheme synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
EYM_03590Aromatic acid decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (191 aa)
EYM_03645Aldehyde ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (604 aa)
EYM_03730Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aspartokinase family. (462 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase; Catalyzes the formation of 3-phospho-D-glycerol phosphate from D-glyceraldehyde 3-phosphate in glycolysis; Derived by automated computational analysis using gene prediction method: Protein Homology. (349 aa)
EYM_03975Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
EYM_03995Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. (310 aa)
EYM_04015Pyruvate ferredoxin oxidoreductase subunit beta; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
EYM_04020Pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
EYM_04025Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (101 aa)
EYM_04030Pyruvate ferredoxin oxidoreductase subunit gamma; Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate to form acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
EYM_04445Histone-lysine N-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (486 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (422 aa)
EYM_04520fatty-acid-CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
EYM_04610Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (645 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (443 aa)
EYM_04745Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (821 aa)
EYM_047952-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
EYM_048002-oxoglutarate ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
EYM_048052-oxoglutarate ferredoxin oxidoreductase subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology. (176 aa)
EYM_048104Fe-4S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (82 aa)
EYM_04935Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (561 aa)
EYM_05450Aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
EYM_054552-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (313 aa)
EYM_05570Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (433 aa)
EYM_06195Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (185 aa)
EYM_06325Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (241 aa)
EYM_06430Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
EYM_06730Glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (294 aa)
EYM_06735Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (721 aa)
EYM_06895Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. (341 aa)
acsA3-hydroxypropionyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (644 aa)
EYM_06970Part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
EYM_07050Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (215 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (300 aa)
EYM_07200Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (497 aa)
apgMPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (412 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (298 aa)
hemLGlutamate-1-semialdehyde aminotransferase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (423 aa)
EYM_07315Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (575 aa)
EYM_07420Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (439 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (223 aa)
EYM_07615Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (656 aa)
EYM_07630Aspartate-semialdehyde dehydrogenase; Catalyzes the formation of aspartate semialdehyde from aspartyl phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (349 aa)
EYM_07790Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (496 aa)
EYM_07860Aldehyde ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (621 aa)
Your Current Organism:
Ignicoccus islandicus
NCBI taxonomy Id: 940295
Other names: I. islandicus DSM 13165, Ignicoccus islandicus DSM 13165, Ignicoccus islandicus Ko18, Ignicoccus islandicus str. DSM 13165, Ignicoccus islandicus strain DSM 13165
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