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| | rlmI | Ribosomal RNA large subunit methyltransferase I; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. (397 aa) |
| | EGA66104.1 | Sulfite reductase gamma subunit-like protein; Part of a sulfur-relay system. (109 aa) |
| | yebU | rRNA (cytosine-C(5)-)-methyltransferase RsmF; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. (474 aa) |
| | rlmL | 23S rRNA m(2)G2445 methyltransferase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. (707 aa) |
| | ttcA | tRNA 2-thiocytidine biosynthesis protein TtcA; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (310 aa) |
| | EGA66190.1 | Hypothetical protein. (237 aa) |
| | rpsT | 30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (86 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (942 aa) |
| | EGA66309.1 | Putative ABC transporter ATP-binding protein; COG0488 ATPase components of ABC transporters with duplicated ATPase domains. (555 aa) |
| | EGA67095.1 | RNA polymerase factor sigma-54; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (488 aa) |
| | rpmE | 50S ribosomal protein L31; Binds the 23S rRNA. (72 aa) |
| | tadA | tRNA-specific adenosine-34 deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (181 aa) |
| | lysS | COG1190 Lysyl-tRNA synthetase (class II); Belongs to the class-II aminoacyl-tRNA synthetase family. (505 aa) |
| | EGA67337.1 | Peptide chain release factor RF-2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (248 aa) |
| | EGA67339.1 | tRNA (adenine-N(6)-)-methyltransferase; Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC). (235 aa) |
| | EGA64999.1 | COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins. (168 aa) |
| | rbgA | GTPase YlqF; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (311 aa) |
| | pnp | Polynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (710 aa) |
| | rpsO | 30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa) |
| | EGA63849.1 | Ribosomal large subunit pseudouridine synthase C; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (319 aa) |
| | rne | Ribonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (980 aa) |
| | rnd | Ribonuclease D; Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family. (346 aa) |
| | EGA63857.1 | Hypothetical protein; COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone. (233 aa) |
| | EGA63862.1 | Protease IV; COG0616 Periplasmic serine proteases (ClpP class). (616 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (435 aa) |
| | dusC | tRNA-dihydrouridine synthase C; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. (317 aa) |
| | EGA63876.1 | tRNA-(MS[2]IO[6]A)-hydroxylase; COG4445 Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA. (256 aa) |
| | rpsA | 30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (556 aa) |
| | EGA64163.1 | COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (313 aa) |
| | EGA64206.1 | COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (305 aa) |
| | EGA64247.1 | Hypothetical transcriptional regulator, LysR family protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (294 aa) |
| | EGA64268.1 | COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (289 aa) |
| | EGA64270.1 | Putative ribosomal large chain pseudouridine synthase A; COG0564 Pseudouridylate synthases, 23S RNA-specific. (559 aa) |
| | EGA66581.1 | COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (304 aa) |
| | EGA66605.1 | COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (296 aa) |
| | EGA66670.1 | COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (316 aa) |
| | EGA66682.1 | Putative glycine cleavage operon activator; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (306 aa) |
| | dusA | tRNA-dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. (333 aa) |
| | rplI | 50S ribosomal protein L9; Binds to the 23S rRNA. (150 aa) |
| | rpsR | 30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (75 aa) |
| | rpsF | 30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (126 aa) |
| | EGA65861.1 | Elongation factor Tu; COG0050 GTPases - translation elongation factors. (40 aa) |
| | EGA65975.1 | COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins. (103 aa) |
| | EGA66879.1 | COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (292 aa) |
| | EGA66890.1 | Transcriptional regulator, LysR family protein; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (298 aa) |
| | EGA66895.1 | Hypothetical protein. (203 aa) |
| | rpmF | COG0333 Ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (56 aa) |
| | cca | 2',3'-cyclic phosphodiesterase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. (403 aa) |
| | rumA | 23S rRNA m(5)U1939 methyltransferase; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (439 aa) |
| | rnc | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (225 aa) |
| | EGA67645.1 | COG0681 Signal peptidase I; Belongs to the peptidase S26 family. (298 aa) |
| | lepA | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (597 aa) |
| | EGA67650.1 | COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (192 aa) |
| | EGA67654.1 | Putative aminomethyltransferase-like GcvT; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family. (322 aa) |
| | glnS | COG0008 Glutamyl- and glutaminyl-tRNA synthetases. (556 aa) |
| | trmB | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (239 aa) |
| | EGA65249.1 | Holliday junction resolvase-like protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (140 aa) |
| | EGA65252.1 | 16S ribosomal RNA methyltransferase RsmE; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (243 aa) |
| | rplU | 50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa) |
| | rpmA | COG0211 Ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (85 aa) |
| | ksgA | 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (268 aa) |
| | rpoD | RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (617 aa) |
| | rpsU | COG0828 Ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (71 aa) |
| | tsaD | UGMP family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (338 aa) |
| | truD | tRNA pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (348 aa) |
| | rpoS | RNA polymerase sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (326 aa) |
| | rpsP | COG0228 Ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (82 aa) |
| | rimM | 16S rRNA-processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (182 aa) |
| | trmD | tRNA (guanine-N(1)-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (247 aa) |
| | rplS | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (117 aa) |
| | EGA65320.1 | Leader peptidase (Prepilin peptidase)/N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (289 aa) |
| | EGA67134.1 | COG1530 Ribonucleases G and E. (489 aa) |
| | EGA67143.1 | COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (194 aa) |
| | rlmG | Ribosomal RNA small subunit methyltransferase C; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. (376 aa) |
| | EGA67149.1 | Cell division protein BolA; COG0271 Stress-induced morphogen (activity unknown); Belongs to the BolA/IbaG family. (102 aa) |
| | rimK | COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); Belongs to the RimK family. (301 aa) |
| | nusB | Transcription antitermination protein NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (155 aa) |
| | EGA64009.1 | COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (299 aa) |
| | EGA64026.1 | Hypothetical protein. (143 aa) |
| | EGA64067.1 | COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (295 aa) |
| | cysS | COG0215 Cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (460 aa) |
| | EGA64125.1 | COG2716 Glycine cleavage system regulatory protein. (170 aa) |
| | EGA64568.1 | COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (300 aa) |
| | EGA64579.1 | COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins. (179 aa) |
| | truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (264 aa) |
| | argS | COG0018 Arginyl-tRNA synthetase. (577 aa) |
| | fliA | Flagellar biosynthesis sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (244 aa) |
| | EGA65576.1 | Hypothetical protein. (242 aa) |
| | EGA65577.1 | COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (194 aa) |
| | EGA65581.1 | LysR family transcriptional regulator, transcriptional activator AphB; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (291 aa) |
| | pcnB | poly(A) polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (455 aa) |
| | gluQ | glutamyl-Q tRNA(Asp) synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (296 aa) |
| | EGA66827.1 | ATP-dependent RNA helicase HrpB; COG1643 HrpA-like helicases. (817 aa) |
| | rsmC | Ribosomal RNA small subunit methyltransferase C; Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle; Belongs to the methyltransferase superfamily. RsmC family. (340 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (395 aa) |
| | greA | Transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (157 aa) |
| | EGA66862.1 | COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein. (98 aa) |
| | rrmJ | 23S rRNA methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (209 aa) |
| | EGA66869.1 | Ribosomal-protein-alanine acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18. (147 aa) |
| | prfC | Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (529 aa) |
| | mnmG | tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (631 aa) |
| | gidB | 16S rRNA methyltransferase GidB; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (210 aa) |
| | trmL | RNA methyltransferase; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. (158 aa) |
| | efp | Elongation factor P; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation; Belongs to the elongation factor P family. (188 aa) |
| | EGA63648.1 | Hypothetical protein. (209 aa) |
| | epmA | poxB regulator PoxA; With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF- P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P; Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily. (323 aa) |
| | trmE | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (453 aa) |
| | rnpA | Ribonuclease P; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (118 aa) |
| | rpmH | COG0230 Ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (44 aa) |
| | glyS | COG0751 Glycyl-tRNA synthetase, beta subunit. (688 aa) |
| | glyQ | COG0752 Glycyl-tRNA synthetase, alpha subunit. (306 aa) |
| | tusA | Sulfur transfer protein SirA; Sulfur carrier protein which probably makes part of a sulfur- relay system; Belongs to the sulfur carrier protein TusA family. (82 aa) |
| | EGA65117.1 | 16S rRNA methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (426 aa) |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (315 aa) |
| | def | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (172 aa) |
| | tsaC | Sua5/YciO/YrdC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. (185 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (475 aa) |
| | miaB | (dimethylallyl)adenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (474 aa) |
| | ybeY | Metal-binding heat shock protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (154 aa) |
| | leuS | COG0495 Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (857 aa) |
| | rlmH | rRNA large subunit methyltransferase; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (156 aa) |
| | lipB | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (221 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa) |
| | EGA65151.1 | COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (190 aa) |
| | tmcA | Hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (665 aa) |
| | EGA65213.1 | COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (301 aa) |
| | EGA65828.1 | COG3036 Uncharacterized protein conserved in bacteria. (69 aa) |
| | EGA65842.1 | Hypothetical protein. (401 aa) |
| | EGA65688.1 | Oxidoreductase; COG2081 Predicted flavoproteins. (397 aa) |
| | rsmJ | SAM-dependent methyltransferase; Specifically methylates the guanosine in position 1516 of 16S rRNA. (259 aa) |
| | EGA65601.1 | COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A). (188 aa) |
| | EGA66482.1 | COG1191 DNA-directed RNA polymerase specialized sigma subunit; Belongs to the sigma-70 factor family. (223 aa) |
| | rnt | Ribonuclease T; Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis. (219 aa) |
| | EGA66518.1 | COG2716 Glycine cleavage system regulatory protein. (180 aa) |
| | EGA66522.1 | Hypothetical protein; Belongs to the sulfur carrier protein TusA family. (61 aa) |
| | EGA66529.1 | Hypothetical protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (157 aa) |
| | prfA | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (362 aa) |
| | pth | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (196 aa) |
| | queG | Iron-sulfur cluster-binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (370 aa) |
| | EGA67731.1 | ATPase YjeE; COG0802 Predicted ATPase or kinase. (154 aa) |
| | miaA | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (316 aa) |
| | EGA67744.1 | Sulfur transfer complex subunit TusD; COG1553 Uncharacterized conserved protein involved in intracellular sulfur reduction. (131 aa) |
| | EGA67745.1 | COG2923 Uncharacterized protein involved in the oxidation of intracellular sulfur; Belongs to the DsrF/TusC family. (118 aa) |
| | EGA67746.1 | Hypothetical protein; COG2168 Uncharacterized conserved protein involved in oxidation of intracellular sulfur. (91 aa) |
| | rpsL | 30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (124 aa) |
| | rpsG | 30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa) |
| | fusA | Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (699 aa) |
| | EGA67750.1 | Elongation factor Tu. (38 aa) |
| | EGA66933.1 | COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. (342 aa) |
| | EGA67046.1 | COG4067 Uncharacterized protein conserved in archaea. (216 aa) |
| | EGA65989.1 | COG4941 Predicted RNA polymerase sigma factor containing a TPR repeat domain; Belongs to the sigma-70 factor family. (409 aa) |
| | EGA67457.1 | COG0180 Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (340 aa) |
| | rlmF | 23S rRNA mA1618 methyltransferase; Specifically methylates the adenine in position 1618 of 23S rRNA. (350 aa) |
| | EGA67562.1 | Type IV pilus biogenesis/stability protein PilW; COG3063 Tfp pilus assembly protein PilF. (163 aa) |
| | EGA64344.1 | COG4067 Uncharacterized protein conserved in archaea. (631 aa) |
| | EGA64345.1 | COG2183 Transcriptional accessory protein. (772 aa) |
| | nfuA | Fe/S biogenesis protein NfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. (195 aa) |
| | trmH | tRNA guanosine-2'-O-methyltransferase; Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (227 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (90 aa) |
| | EGA65363.1 | COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (305 aa) |
| | EGA65403.1 | COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins. (172 aa) |
| | def-2 | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (167 aa) |
| | rplT | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (117 aa) |
| | rpmI | COG0291 Ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (64 aa) |
| | EGA65431.1 | Translation initiation factor 3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (129 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (642 aa) |
| | zntR | COG0789 Predicted transcriptional regulators. (146 aa) |
| | EGA66732.1 | NifR3/Smm1 family protein; COG0042 tRNA-dihydrouridine synthase. (280 aa) |
| | EGA66775.1 | L-asparaginase; COG1446 Asparaginase. (313 aa) |
| | rlmB | 23S rRNA (guanosine-2'-O-)-methyltransferase; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. (245 aa) |
| | rpsJ | 30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa) |
| | rplC | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (209 aa) |
| | rplD | 50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (200 aa) |
| | rplW | 50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (100 aa) |
| | rplB | 50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (274 aa) |
| | rpsS | 30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa) |
| | rplV | 50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (110 aa) |
| | rpsC | 30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (232 aa) |
| | rplP | 50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (136 aa) |
| | rpmC | COG0255 Ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (63 aa) |
| | rpsQ | 30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (84 aa) |
| | rplN | 50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (123 aa) |
| | rplX | 50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (105 aa) |
| | rplE | 50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa) |
| | rpsN | 30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa) |
| | rpsH | 30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | rplF | 50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa) |
| | rplR | 50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (117 aa) |
| | rpsE | 30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (167 aa) |
| | rpmD | COG1841 Ribosomal protein L30/L7E. (58 aa) |
| | rplO | 50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa) |
| | rpmJ | COG0257 Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (37 aa) |
| | rpsM | 30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (118 aa) |
| | rpsK | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa) |
| | rpsD | 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (206 aa) |
| | rpoA | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (330 aa) |
| | rplQ | COG0203 Ribosomal protein L17. (126 aa) |
| | EGA63913.1 | Elongation factor Tu; COG0050 GTPases - translation elongation factors. (314 aa) |
| | EGA66322.1 | COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins. (192 aa) |
| | asnC | COG0017 Aspartyl/asparaginyl-tRNA synthetases. (466 aa) |
| | EGA66348.1 | Putative ATP-dependent helicase; COG1643 HrpA-like helicases. (781 aa) |
| | EGA66359.1 | COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. (312 aa) |
| | EGA66360.1 | Hypothetical protein; COG0009 Putative translation factor (SUA5); Belongs to the SUA5 family. (206 aa) |
| | EGA66375.1 | COG1643 HrpA-like helicases. (1307 aa) |
| | EGA66445.1 | Putative ribosomal-protein-serine acetyltransferase; COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins. (179 aa) |
| | EGA65942.1 | Hypothetical protein; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle; Belongs to the methyltransferase superfamily. RsmD family. (200 aa) |
| | rpoH | RNA polymerase factor sigma-32; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (285 aa) |
| | EGA63664.1 | Hypothetical protein; COG1561 Uncharacterized stress-induced protein. (288 aa) |
| | rph | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (238 aa) |
| | rpmB | COG0227 Ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (78 aa) |
| | rpmG | COG0267 Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (56 aa) |
| | pheS | COG0016 Phenylalanyl-tRNA synthetase alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (327 aa) |
| | pheT | phenylalanyl-tRNA synthetase subunit beta; COG0073 EMAP domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (801 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (345 aa) |
| | smpB | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (161 aa) |
| | EGA64824.1 | RNA methyltransferase, TrmH family; COG0566 rRNA methylases. (244 aa) |
| | EGA64898.1 | COG1186 Protein chain release factor B. (137 aa) |
| | EGA63717.1 | Elongation factor Tu. (38 aa) |
| | EGA67185.1 | COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (299 aa) |
| | EGA67227.1 | LysR family substrate binding transcriptional regulator; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (302 aa) |
| | EGA67230.1 | tRNA-binding protein; COG0073 EMAP domain. (110 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (378 aa) |
| | EGA67254.1 | COG1145 Ferredoxin. (84 aa) |
| | EGA67288.1 | Hypothetical protein; COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1. (269 aa) |
| | rlmN | Ribosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (375 aa) |
| | hisS | COG0124 Histidyl-tRNA synthetase. (412 aa) |
| | EGA67297.1 | COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain. (288 aa) |
| | EGA67307.1 | COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (289 aa) |
| | EGA67314.1 | Putative translation factor; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (320 aa) |
| | mnmC | Bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the C-terminal section; belongs to the DAO family. (672 aa) |
| | infA | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa) |
| | EGA63623.1 | COG0724 RNA-binding proteins (RRM domain). (149 aa) |
| | trmA | tRNA (uracil-5-)-methyltransferase; Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA). (369 aa) |
| | EGA66701.1 | Elongation factor Tu; COG0050 GTPases - translation elongation factors. (40 aa) |
| | nusG | Transcription antitermination protein NusG; Participates in transcription elongation, termination and antitermination. (182 aa) |
| | rplK | 50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (142 aa) |
| | rplA | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (233 aa) |
| | rplJ | 50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (164 aa) |
| | rplL | 50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1342 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1400 aa) |
| | EGA65920.1 | Ribosomal large subunit pseudouridine synthase A; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (245 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (952 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (860 aa) |
| | fusA-2 | Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (695 aa) |
| | EGA64113.1 | HesB family protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. (107 aa) |
| | trmJ | rRNA methylase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. (241 aa) |
| | cmoM | Putative S-adenosyl-L-methionine-dependent methyltransferase; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family. (260 aa) |
| | EGA65637.1 | COG4067 Uncharacterized protein conserved in archaea. (239 aa) |
| | cmoB | tRNA mo(5)U34 methyltransferase; Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethoxyuridine (cmo5U) at position 34 in tRNAs. (323 aa) |
| | cmoA | Hypothetical protein; Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM). (245 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (592 aa) |
| | EGA65643.1 | Ribosomal large subunit pseudouridine synthase E; COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. (230 aa) |
| | rluD | 23S rRNA pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (326 aa) |
| | rpmJ-2 | COG0257 Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (41 aa) |
| | rpmE2 | COG0254 Ribosomal protein L31. (86 aa) |
| | EGA63587.1 | Hypothetical protein. (231 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (571 aa) |
| | tilS | tRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (439 aa) |
| | EGA63610.1 | Chaperone protein skp; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. (169 aa) |
| | frr | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa) |
| | tsf | Elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (280 aa) |
| | rpsB | COG0052 Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (242 aa) |
| | EGA64373.1 | COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins. (172 aa) |
| | rplY | 50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. (92 aa) |
| | EGA64425.1 | Ribosomal small subunit pseudouridine synthase A; COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. (233 aa) |
| | rlmJ | Putative DNA (exogenous) processing protein; Specifically methylates the adenine in position 2030 of 23S rRNA. (279 aa) |
| | EGA64718.1 | Hypothetical protein. (72 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (419 aa) |
| | EGA63832.1 | COG0564 Pseudouridylate synthases, 23S RNA-specific. (240 aa) |
| | thiI | tRNA s(4)U8 sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa) |
| | EGA63841.1 | DNA-binding transcriptional activator GcvA; COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (302 aa) |
| | rlmM | Putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily. (363 aa) |
| | rsmH | 16S rRNA m(4)C1402 methyltranserfase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (316 aa) |
| | rsmI | Tetrapyrrole (Corrin-Porphyrin) methylase family protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (287 aa) |
| | rpsI | COG0103 Ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (130 aa) |
| | rplM | 50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa) |
| | truB | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (315 aa) |
| | rbfA | Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (136 aa) |
| | infB | Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (895 aa) |
| | nusA | Transcription elongation factor NusA; Participates in both transcription termination and antitermination. (495 aa) |
| | mnmA | tRNA-specific 2-thiouridylase MnmA; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (378 aa) |
| | EGA63975.1 | Pseudouridine synthase Rlu family protein; COG0564 Pseudouridylate synthases, 23S RNA-specific. (231 aa) |
| | EGA63976.1 | Methyltransferase; COG1092 Predicted SAM-dependent methyltransferases; Belongs to the methyltransferase superfamily. (310 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (686 aa) |
