(10 nodes) ERAD pathway network (Salpingoeca rosetta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTSG_01086	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (244 aa)
	PTSG_02184	RING-type domain-containing protein. (539 aa)
	PTSG_06926	Uncharacterized protein. (403 aa)
	PTSG_06462	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (304 aa)
	PTSG_12692	Uncharacterized protein. (1009 aa)
	PTSG_08313	Uncharacterized protein. (176 aa)
	PTSG_12705	Uncharacterized protein. (447 aa)
	PTSG_12809	Uncharacterized protein. (491 aa)
	PTSG_09518	RING-type domain-containing protein. (233 aa)
	PTSG_10082	Erlin-1. (321 aa)

Your Current Organism:

Salpingoeca rosetta

NCBI taxonomy Id: 946362
Other names: Proterospongia sp. ATCC 50818, S. rosetta, Salpingoeca rosetta ATCC 50818, Salpingoeca rosetta ATCC50818, Salpingoeca rosetta Dayel et al. 2011, Salpingoeca sp. ATCC 50818, Salpingoeca sp. ATCC50818

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PTSG_01086	PTSG_02184	F2U0S0	F2U1G4	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	RING-type domain-containing protein.	0.997
PTSG_01086	PTSG_06462	F2U0S0	F2UFV7	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.994
PTSG_01086	PTSG_06926	F2U0S0	F2UF73	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Uncharacterized protein.	0.871
PTSG_01086	PTSG_08313	F2U0S0	F2UJC2	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Uncharacterized protein.	0.871
PTSG_01086	PTSG_09518	F2U0S0	F2UL85	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	RING-type domain-containing protein.	0.821
PTSG_01086	PTSG_10082	F2U0S0	F2UPF6	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Erlin-1.	0.675
PTSG_01086	PTSG_12692	F2U0S0	F2UI80	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Uncharacterized protein.	0.871
PTSG_01086	PTSG_12705	F2U0S0	F2UJC4	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Uncharacterized protein.	0.871
PTSG_01086	PTSG_12809	F2U0S0	F2UL24	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Uncharacterized protein.	0.991
PTSG_02184	PTSG_01086	F2U1G4	F2U0S0	RING-type domain-containing protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.997
PTSG_02184	PTSG_06462	F2U1G4	F2UFV7	RING-type domain-containing protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.998
PTSG_02184	PTSG_06926	F2U1G4	F2UF73	RING-type domain-containing protein.	Uncharacterized protein.	0.862
PTSG_02184	PTSG_08313	F2U1G4	F2UJC2	RING-type domain-containing protein.	Uncharacterized protein.	0.862
PTSG_02184	PTSG_09518	F2U1G4	F2UL85	RING-type domain-containing protein.	RING-type domain-containing protein.	0.473
PTSG_02184	PTSG_12692	F2U1G4	F2UI80	RING-type domain-containing protein.	Uncharacterized protein.	0.862
PTSG_02184	PTSG_12705	F2U1G4	F2UJC4	RING-type domain-containing protein.	Uncharacterized protein.	0.862
PTSG_02184	PTSG_12809	F2U1G4	F2UL24	RING-type domain-containing protein.	Uncharacterized protein.	0.997
PTSG_06462	PTSG_01086	F2UFV7	F2U0S0	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.994
PTSG_06462	PTSG_02184	F2UFV7	F2U1G4	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	RING-type domain-containing protein.	0.998
PTSG_06462	PTSG_06926	F2UFV7	F2UF73	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	Uncharacterized protein.	0.879

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