(118 nodes) RHO GTPase cycle, and EPH-Ephrin signaling network (Salpingoeca rosetta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTSG_00038	Uncharacterized protein. (1250 aa)
	PTSG_00040	Uncharacterized protein. (966 aa)
	PTSG_00107	Protein kinase domain-containing protein. (180 aa)
	PTSG_00196	Uncharacterized protein. (1233 aa)
	PTSG_00306	ARHA protein. (191 aa)
	PTSG_00346	TK protein kinase. (973 aa)
	PTSG_00372	Uncharacterized protein. (1659 aa)
	PTSG_00515	L-plastin. (629 aa)
	PTSG_00652	Plexin-A4 protein. (2078 aa)
	PTSG_00831	Uncharacterized protein. (642 aa)
	PTSG_11656	CUE domain-containing protein. (912 aa)
	PTSG_00915	SECA_MOTOR_DEAD domain-containing protein. (1877 aa)
	PTSG_11758	Uncharacterized protein. (565 aa)
	PTSG_11774	Uncharacterized protein. (186 aa)
	PTSG_01821	Uncharacterized protein. (1113 aa)
	PTSG_01931	Uncharacterized protein. (570 aa)
	PTSG_01307	Uncharacterized protein. (320 aa)
	PTSG_01339	SH3 domain-containing protein. (867 aa)
	PTSG_01373	Uncharacterized protein. (1362 aa)
	PTSG_01394	Ras-GEF domain-containing protein. (1407 aa)
	PTSG_01477	Non-specific serine/threonine protein kinase. (503 aa)
	PTSG_01554	Cofilin; Belongs to the actin-binding proteins ADF family. (140 aa)
	PTSG_01146	Uncharacterized protein. (1194 aa)
	PTSG_01216	E3 ubiquitin-protein ligase. (910 aa)
	PTSG_02177	Uncharacterized protein. (787 aa)
	PTSG_02449	Uncharacterized protein. (348 aa)
	PTSG_02542	SH3 domain-containing protein. (391 aa)
	PTSG_02093	Uncharacterized protein. (961 aa)
	PTSG_02104	Uncharacterized protein. (183 aa)
	PTSG_02586	Reggie 1b; Belongs to the band 7/mec-2 family. Flotillin subfamily. (438 aa)
	PTSG_02660	Uncharacterized protein. (503 aa)
	PTSG_02806	Profilin; Belongs to the profilin family. (129 aa)
	PTSG_02984	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (192 aa)
	PTSG_11974	Non-specific serine/threonine protein kinase. (1740 aa)
	PTSG_11992	Uncharacterized protein. (362 aa)
	PTSG_12020	Uncharacterized protein. (1346 aa)
	PTSG_12026	Uncharacterized protein. (409 aa)
	PTSG_03557	Endophilin. (327 aa)
	PTSG_03604	SH3 domain-containing protein. (472 aa)
	PTSG_03696	Uncharacterized protein. (1495 aa)
	PTSG_04167	Uncharacterized protein. (189 aa)
	PTSG_03925	Uncharacterized protein. (301 aa)
	PTSG_03928	Uncharacterized protein. (289 aa)
	PTSG_12100	Uncharacterized protein. (846 aa)
	PTSG_04062	Uncharacterized protein. (374 aa)
	PTSG_04584	TK/RTKC protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (2249 aa)
	PTSG_12191	TK/RTKC protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (2478 aa)
	PTSG_04362	Uncharacterized protein. (1809 aa)
	PTSG_12168	Uncharacterized protein. (1777 aa)
	PTSG_04512	Myosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1062 aa)
	PTSG_12248	Uncharacterized protein. (520 aa)
	PTSG_04848	BAR domain-containing protein. (249 aa)
	PTSG_04851	Profilin; Belongs to the profilin family. (128 aa)
	PTSG_05106	Beta actin; Belongs to the actin family. (2078 aa)
	PTSG_12260	Uncharacterized protein. (1183 aa)
	PTSG_05118	F-BAR domain-containing protein. (279 aa)
	PTSG_05191	Uncharacterized protein. (177 aa)
	PTSG_05221	Uncharacterized protein. (423 aa)
	PTSG_05464	Uncharacterized protein. (1104 aa)
	PTSG_05517	DH domain-containing protein. (378 aa)
	PTSG_05571	PDZ domain-containing protein. (455 aa)
	PTSG_05588	Calponin-homology (CH) domain-containing protein. (114 aa)
	PTSG_05616	WH2 domain-containing protein. (354 aa)
	PTSG_06411	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (178 aa)
	PTSG_06187	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (172 aa)
	PTSG_06287	SECA_MOTOR_DEAD domain-containing protein. (1800 aa)
	PTSG_06317	Beta-actin 2; Belongs to the actin family. (375 aa)
	PTSG_06383	Flotillin 1; Belongs to the band 7/mec-2 family. Flotillin subfamily. (426 aa)
	PTSG_05851	Uncharacterized protein. (756 aa)
	PTSG_05878	Uncharacterized protein. (463 aa)
	PTSG_05879	Actin; Belongs to the actin family. (1647 aa)
	PTSG_06029	Serine/threonine protein kinase. (302 aa)
	PTSG_06036	Uncharacterized protein. (494 aa)
	PTSG_07003	Uncharacterized protein. (933 aa)
	PTSG_07054	TK protein kinase. (1453 aa)
	PTSG_12558	GMFB protein; Belongs to the actin-binding proteins ADF family. GMF subfamily. (140 aa)
	PTSG_07236	TKL/LISK/LIMK protein kinase. (881 aa)
	PTSG_06733	Rac GTPase. (191 aa)
	PTSG_06787	WH2 domain-containing protein. (539 aa)
	PTSG_06844	Uncharacterized protein. (1161 aa)
	PTSG_06902	Uncharacterized protein. (696 aa)
	PTSG_12505	Uncharacterized protein; Belongs to the actin family. (411 aa)
	PTSG_06933	FH2 domain-containing protein. (695 aa)
	PTSG_06934	Drf_GBD domain-containing protein. (179 aa)
	PTSG_06982	BRICK 1 protein. (133 aa)
	PTSG_06685	Rho1 GTPase. (193 aa)
	PTSG_06501	TK protein kinase. (1588 aa)
	PTSG_07959	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1698 aa)
	PTSG_07580	Uncharacterized protein. (1502 aa)
	PTSG_07621	SH3 domain-containing protein. (418 aa)
	PTSG_08192	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (457 aa)
	PTSG_12696	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (391 aa)
	PTSG_07384	Ras-GAP domain-containing protein. (1011 aa)
	PTSG_07365	Beta-centractin; Belongs to the actin family. (376 aa)
	PTSG_12757	AGC/DMPK/ROCK protein kinase. (4089 aa)
	PTSG_08756	Uncharacterized protein. (799 aa)
	PTSG_09554	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (295 aa)
	PTSG_08994	Rho-GAP domain-containing protein. (676 aa)
	PTSG_09015	Uncharacterized protein. (1625 aa)
	PTSG_12828	OrfB_Zn_ribbon domain-containing protein. (1534 aa)
	PTSG_09327	Act-Frag_cataly domain-containing protein. (666 aa)
	PTSG_09415	PH domain-containing protein. (990 aa)
	PTSG_09872	Uncharacterized protein. (462 aa)
	PTSG_09943	Uncharacterized protein. (484 aa)
	PTSG_10427	Uncharacterized protein. (3457 aa)
	PTSG_10428	Profilin; Belongs to the profilin family. (127 aa)
	PTSG_10429	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (379 aa)
	PTSG_13048	Calponin-homology (CH) domain-containing protein. (1971 aa)
	PTSG_10788	Adenylyl cyclase-associated protein; Belongs to the CAP family. (468 aa)
	PTSG_10140	ADF-H domain-containing protein. (637 aa)
	PTSG_10198	Uncharacterized protein. (192 aa)
	PTSG_10315	Uncharacterized protein. (1406 aa)
	PTSG_10906	WD_REPEATS_REGION domain-containing protein. (664 aa)
	PTSG_11059	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (2061 aa)
	PTSG_11108	AGC/DMPK protein kinase. (1837 aa)
	PTSG_11002	Rho-GAP domain-containing protein. (560 aa)
	PTSG_11390	Uncharacterized protein. (132 aa)
	PTSG_13212	ANK_REP_REGION domain-containing protein. (317 aa)

Your Current Organism:

Salpingoeca rosetta

NCBI taxonomy Id: 946362
Other names: Proterospongia sp. ATCC 50818, S. rosetta, Salpingoeca rosetta ATCC 50818, Salpingoeca rosetta ATCC50818, Salpingoeca rosetta Dayel et al. 2011, Salpingoeca sp. ATCC 50818, Salpingoeca sp. ATCC50818

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PTSG_00038	PTSG_00306	F2TVC6	F2TW39	Uncharacterized protein.	ARHA protein.	0.644
PTSG_00038	PTSG_01339	F2TVC6	F2U023	Uncharacterized protein.	SH3 domain-containing protein.	0.654
PTSG_00038	PTSG_02984	F2TVC6	F2U3X5	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.691
PTSG_00038	PTSG_03604	F2TVC6	F2U627	Uncharacterized protein.	SH3 domain-containing protein.	0.951
PTSG_00038	PTSG_05464	F2TVC6	F2UBA5	Uncharacterized protein.	Uncharacterized protein.	0.988
PTSG_00038	PTSG_05851	F2TVC6	F2UCZ2	Uncharacterized protein.	Uncharacterized protein.	0.973
PTSG_00038	PTSG_06187	F2TVC6	F2UC72	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.	0.671
PTSG_00038	PTSG_06411	F2TVC6	F2UBY5	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.	0.645
PTSG_00038	PTSG_06685	F2TVC6	F2UFQ0	Uncharacterized protein.	Rho1 GTPase.	0.552
PTSG_00038	PTSG_06733	F2TVC6	F2UEM7	Uncharacterized protein.	Rac GTPase.	0.644
PTSG_00038	PTSG_06787	F2TVC6	F2UET2	Uncharacterized protein.	WH2 domain-containing protein.	0.923
PTSG_00038	PTSG_06902	F2TVC6	F2UF48	Uncharacterized protein.	Uncharacterized protein.	0.793
PTSG_00038	PTSG_06982	F2TVC6	F2UFD3	Uncharacterized protein.	BRICK 1 protein.	0.953
PTSG_00038	PTSG_07003	F2TVC6	F2UDR6	Uncharacterized protein.	Uncharacterized protein.	0.958
PTSG_00038	PTSG_07621	F2TVC6	F2UHA5	Uncharacterized protein.	SH3 domain-containing protein.	0.799
PTSG_00038	PTSG_09554	F2TVC6	F2ULC0	Uncharacterized protein.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.719
PTSG_00038	PTSG_10198	F2TVC6	F2UQL1	Uncharacterized protein.	Uncharacterized protein.	0.644
PTSG_00038	PTSG_10429	F2TVC6	F2UPM5	Uncharacterized protein.	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.649
PTSG_00038	PTSG_11758	F2TVC6	F2TYD2	Uncharacterized protein.	Uncharacterized protein.	0.723
PTSG_00038	PTSG_12248	F2TVC6	F2U9C9	Uncharacterized protein.	Uncharacterized protein.	0.923

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