(97 nodes) Negative regulation of signal transduction network (Salpingoeca rosetta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTSG_00975	3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
	PTSG_11108	AGC/DMPK protein kinase. (1837 aa)
	PTSG_10551	Uncharacterized protein; Belongs to the BI1 family. (335 aa)
	PTSG_10914	TKL protein kinase. (2214 aa)
	PTSG_10751	Uncharacterized protein. (298 aa)
	PTSG_10732	Uncharacterized protein. (155 aa)
	PTSG_10712	SH2 domain-containing protein. (494 aa)
	PTSG_10793	TK protein kinase, variant; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1438 aa)
	PTSG_10052	Senescence domain-containing protein. (404 aa)
	PTSG_12971	Uncharacterized protein. (772 aa)
	PTSG_09266	Major vault protein. (853 aa)
	PTSG_09400	Rab7 GTPase. (206 aa)
	PTSG_09303	PPM-type phosphatase domain-containing protein. (378 aa)
	PTSG_09628	Uncharacterized protein. (357 aa)
	PTSG_09506	Uncharacterized protein. (553 aa)
	PTSG_08747	TK/HMTK protein kinase. (1274 aa)
	PTSG_08671	Uncharacterized protein. (777 aa)
	PTSG_08579	RB_A domain-containing protein. (816 aa)
	PTSG_08572	TK protein kinase. (571 aa)
	PTSG_07297	Uncharacterized protein. (241 aa)
	PTSG_07451	WD_REPEATS_REGION domain-containing protein. (764 aa)
	PTSG_07384	Ras-GAP domain-containing protein. (1011 aa)
	PTSG_07382	Arrestin_C domain-containing protein. (858 aa)
	PTSG_07380	Uncharacterized protein. (761 aa)
	PTSG_08136	JmjC domain-containing protein. (776 aa)
	PTSG_08081	Uncharacterized protein. (129 aa)
	PTSG_07730	Camk/mapkapk/mapkapk protein kinase. (437 aa)
	PTSG_07725	TK/HMTK protein kinase. (701 aa)
	PTSG_12605	TK/ABL protein kinase. (2625 aa)
	PTSG_07550	TK protein kinase. (1773 aa)
	PTSG_07791	SH2 domain-containing protein. (1053 aa)
	PTSG_06495	Uncharacterized protein. (328 aa)
	PTSG_06594	PPM-type phosphatase domain-containing protein. (572 aa)
	PTSG_06902	Uncharacterized protein. (696 aa)
	PTSG_06757	Uncharacterized protein. (354 aa)
	PTSG_06747	Uncharacterized protein. (952 aa)
	PTSG_07140	TK/HMTK protein kinase. (589 aa)
	PTSG_07139	TK/HMTK protein kinase. (535 aa)
	PTSG_07022	Uncharacterized protein. (527 aa)
	PTSG_07015	FCP1 homology domain-containing protein. (797 aa)
	PTSG_06061	SAM domain-containing protein. (920 aa)
	PTSG_05911	Uncharacterized protein. (296 aa)
	PTSG_05822	RING-type domain-containing protein. (636 aa)
	PTSG_05814	PH domain-containing protein. (436 aa)
	PTSG_06379	Nucleoside diphosphate kinase; Belongs to the NDK family. (169 aa)
	PTSG_12431	BTB domain-containing protein. (1033 aa)
	PTSG_06320	CDT1 domain-containing protein. (793 aa)
	PTSG_06415	TK/ABL protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (699 aa)
	PTSG_06413	Sortilin. (1168 aa)
	PTSG_05587	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (2878 aa)
	PTSG_05534	Uncharacterized protein. (253 aa)
	PTSG_05229	PH domain-containing protein. (287 aa)
	PTSG_05259	SAM domain-containing protein. (581 aa)
	PTSG_04856	SAM domain-containing protein. (710 aa)
	PTSG_04961	AGC/NDR protein kinase. (833 aa)
	PTSG_04921	Uncharacterized protein. (588 aa)
	PTSG_04885	Dual specificity phosphatase 6. (447 aa)
	PTSG_04334	Phosphatase 1B. (609 aa)
	PTSG_04555	PPM-type phosphatase domain-containing protein. (365 aa)
	PTSG_03973	Uncharacterized protein. (91 aa)
	PTSG_03898	SH2 domain-containing protein. (455 aa)
	PTSG_04223	TK protein kinase. (1700 aa)
	PTSG_04107	SAM domain and HD domain-containing protein 1. (580 aa)
	PTSG_03756	Uncharacterized protein. (540 aa)
	PTSG_03705	Uncharacterized protein. (180 aa)
	PTSG_03808	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (208 aa)
	PTSG_03766	Camk/mapkapk/mapkapk protein kinase. (461 aa)
	PTSG_03406	UBIQUITIN_CONJUGAT_2 domain-containing protein. (270 aa)
	PTSG_03351	SH2 domain-containing protein. (954 aa)
	PTSG_03234	TK/HMTK protein kinase. (703 aa)
	PTSG_02847	TK/HMTK protein kinase. (1184 aa)
	PTSG_02611	PDZ domain-containing protein. (931 aa)
	PTSG_02076	Tryparedoxin. (181 aa)
	PTSG_11870	Uncharacterized protein. (731 aa)
	PTSG_01208	Uncharacterized protein. (768 aa)
	PTSG_01193	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (831 aa)
	PTSG_01549	Legumain. (456 aa)
	PTSG_01525	Uncharacterized protein. (634 aa)
	PTSG_01996	OTU domain-containing protein. (408 aa)
	PTSG_01982	TFIIS N-terminal domain-containing protein. (335 aa)
	PTSG_01981	C3H1-type domain-containing protein. (391 aa)
	PTSG_01922	Uncharacterized protein. (957 aa)
	PTSG_01790	Guanine nucleotide binding protein. (312 aa)
	PTSG_01771	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (650 aa)
	PTSG_01770	Uncharacterized protein. (265 aa)
	PTSG_01002	Uncharacterized protein. (609 aa)
	PTSG_00939	PH domain-containing protein. (272 aa)
	PTSG_00935	Uncharacterized protein; Belongs to the BI1 family. (258 aa)
	PTSG_11638	Uncharacterized protein. (1560 aa)
	PTSG_00669	Uncharacterized protein. (2865 aa)
	PTSG_11599	Uncharacterized protein. (624 aa)
	PTSG_00516	Uncharacterized protein. (6014 aa)
	PTSG_00458	ULK/ULK protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	PTSG_00317	Uncharacterized protein. (1543 aa)
	PTSG_00206	Uncharacterized protein. (340 aa)
	PTSG_00189	JmjC domain-containing protein. (334 aa)
	PTSG_00161	Uncharacterized protein. (459 aa)

Your Current Organism:

Salpingoeca rosetta

NCBI taxonomy Id: 946362
Other names: Proterospongia sp. ATCC 50818, S. rosetta, Salpingoeca rosetta ATCC 50818, Salpingoeca rosetta ATCC50818, Salpingoeca rosetta Dayel et al. 2011, Salpingoeca sp. ATCC 50818, Salpingoeca sp. ATCC50818

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PTSG_00317	PTSG_11638	F2TW52	F2TXD7	Uncharacterized protein.	Uncharacterized protein.	0.932
PTSG_00516	PTSG_01193	F2TWP4	F2U130	Uncharacterized protein.	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.445
PTSG_00516	PTSG_02847	F2TWP4	F2U3H9	Uncharacterized protein.	TK/HMTK protein kinase.	0.445
PTSG_00516	PTSG_03234	F2TWP4	F2U4L6	Uncharacterized protein.	TK/HMTK protein kinase.	0.445
PTSG_00516	PTSG_03406	F2TWP4	F2U539	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.679
PTSG_00516	PTSG_03898	F2TWP4	F2U771	Uncharacterized protein.	SH2 domain-containing protein.	0.445
PTSG_00516	PTSG_04223	F2TWP4	F2U6Y3	Uncharacterized protein.	TK protein kinase.	0.445
PTSG_00516	PTSG_05587	F2TWP4	F2UBM6	Uncharacterized protein.	TK protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.445
PTSG_00516	PTSG_06415	F2TWP4	F2UBY9	Uncharacterized protein.	TK/ABL protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.445
PTSG_00516	PTSG_07139	F2TWP4	F2UE61	Uncharacterized protein.	TK/HMTK protein kinase.	0.445
PTSG_00516	PTSG_07140	F2TWP4	F2UE62	Uncharacterized protein.	TK/HMTK protein kinase.	0.445
PTSG_00516	PTSG_07451	F2TWP4	F2UIR8	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.467
PTSG_00516	PTSG_07550	F2TWP4	F2UH34	Uncharacterized protein.	TK protein kinase.	0.445
PTSG_00516	PTSG_07725	F2TWP4	F2UHL1	Uncharacterized protein.	TK/HMTK protein kinase.	0.445
PTSG_00516	PTSG_08572	F2TWP4	F2UK27	Uncharacterized protein.	TK protein kinase.	0.445
PTSG_00516	PTSG_08747	F2TWP4	F2UKK5	Uncharacterized protein.	TK/HMTK protein kinase.	0.445
PTSG_00516	PTSG_10712	F2TWP4	F2UQ60	Uncharacterized protein.	SH2 domain-containing protein.	0.445
PTSG_00516	PTSG_10793	F2TWP4	F2UPY0	Uncharacterized protein.	TK protein kinase, variant; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.445
PTSG_00516	PTSG_12605	F2TWP4	F2UH35	Uncharacterized protein.	TK/ABL protein kinase.	0.445
PTSG_00935	PTSG_10551	F2TXX4	F2URP0	Uncharacterized protein; Belongs to the BI1 family.	Uncharacterized protein; Belongs to the BI1 family.	0.629

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