(66 nodes) Nucleic acid-binding, OB-fold network (Salpingoeca rosetta)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PTSG_05708	Rpt3-PA; Belongs to the AAA ATPase family. (405 aa)
	PTSG_05609	Ribosomal protein S28. (66 aa)
	PTSG_12399	Eukaryotic translation initiation factor 5A. (150 aa)
	PTSG_06148	Uncharacterized protein. (106 aa)
	PTSG_06376	RNB domain-containing protein. (925 aa)
	PTSG_05806	Eukaryotic translation initiation factor 2 subunit 1. (301 aa)
	PTSG_05810	KH_dom_type_1 domain-containing protein. (264 aa)
	PTSG_05821	Uncharacterized protein. (147 aa)
	PTSG_06055	Uncharacterized protein. (166 aa)
	PTSG_12525	Uncharacterized protein. (974 aa)
	PTSG_07053	Uncharacterized protein. (856 aa)
	PTSG_07071	DNA helicase; Belongs to the MCM family. (705 aa)
	PTSG_12543	DNA helicase; Belongs to the MCM family. (1619 aa)
	PTSG_06672	Uncharacterized protein. (765 aa)
	PTSG_06492	Lysine--tRNA ligase. (498 aa)
	PTSG_07952	Uncharacterized protein. (3252 aa)
	PTSG_08018	Ribosomal protein L8. (255 aa)
	PTSG_08033	DNA replication licensing factor MCM9; Belongs to the MCM family. (1237 aa)
	PTSG_12677	OB domain-containing protein. (167 aa)
	PTSG_08758	Asparaginyl-tRNA synthetase. (608 aa)
	PTSG_08790	TYR_PHOSPHATASE_2 domain-containing protein. (812 aa)
	PTSG_09444	26S proteasome subunit ATPase 4; Belongs to the AAA ATPase family. (309 aa)
	PTSG_12966	Uncharacterized protein. (2005 aa)
	PTSG_10860	Uncharacterized protein. (95 aa)
	PTSG_10945	DNA ligase. (1246 aa)
	PTSG_10947	Replication protein A subunit. (601 aa)
	PTSG_11230	Ribosomal protein S23e; Belongs to the universal ribosomal protein uS12 family. (143 aa)
	PTSG_00362	Uncharacterized protein. (484 aa)
	PTSG_11588	DNA helicase; Belongs to the MCM family. (813 aa)
	PTSG_00566	S1 motif domain-containing protein. (171 aa)
	PTSG_11661	DNA ligase. (1437 aa)
	PTSG_11681	40S ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family. (156 aa)
	PTSG_01071	Lysine--tRNA ligase. (796 aa)
	PTSG_01772	26S protease regulatory subunit 7. (262 aa)
	PTSG_01777	Peptidase 26S subunit; Belongs to the AAA ATPase family. (411 aa)
	PTSG_01303	AA_TRNA_LIGASE_II domain-containing protein. (695 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (725 aa)
	PTSG_11709	Uncharacterized protein. (122 aa)
	PTSG_01490	RPA_C domain-containing protein. (294 aa)
	PTSG_01110	Zinc finger protein. (266 aa)
	PTSG_01195	Minichromosomal maintenance factor; Belongs to the MCM family. (858 aa)
	PTSG_01203	Mcm10 domain-containing protein. (786 aa)
	PTSG_01222	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (140 aa)
	PTSG_02359	Rrp4-PA. (301 aa)
	PTSG_02410	RNB domain-containing protein; Belongs to the RNR ribonuclease family. (1023 aa)
	PTSG_02420	ECR1_N domain-containing protein. (178 aa)
	PTSG_02422	Uncharacterized protein. (64 aa)
	PTSG_02505	Mitotic control protein dis3; Belongs to the RNR ribonuclease family. (1066 aa)
	PTSG_02565	Minichromosome maintenance protein 8; Belongs to the MCM family. (1051 aa)
	PTSG_02587	Telo_bind domain-containing protein. (743 aa)
	PTSG_02848	DEAH box polypeptide 8. (1288 aa)
	PTSG_03377	Uncharacterized protein. (146 aa)
	PTSG_03715	Eukaryotic translation initiation factor 4C; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (154 aa)
	PTSG_04225	S1 motif domain-containing protein. (1774 aa)
	PTSG_03953	26S proteasome regulatory complex ATPase RPT4; Belongs to the AAA ATPase family. (391 aa)
	PTSG_04050	Uncharacterized protein. (117 aa)
	PTSG_04052	DNA ligase. (1207 aa)
	PTSG_04653	30S ribosomal protein S17; Belongs to the universal ribosomal protein uS17 family. (100 aa)
	PTSG_04316	DNA helicase; Belongs to the MCM family. (862 aa)
	PTSG_04498	Aspartyl-tRNA synthetase. (535 aa)
	PTSG_04881	Asparaginyl-tRNA synthetase. (506 aa)
	PTSG_05019	Uncharacterized protein. (660 aa)
	PTSG_04760	Proteasome 26S subunit; Belongs to the AAA ATPase family. (424 aa)
	PTSG_05411	Uncharacterized protein. (203 aa)
	PTSG_05144	DNA ligase. (664 aa)
	PTSG_12335	Uncharacterized protein. (350 aa)

Your Current Organism:

Salpingoeca rosetta

NCBI taxonomy Id: 946362
Other names: Proterospongia sp. ATCC 50818, S. rosetta, Salpingoeca rosetta ATCC 50818, Salpingoeca rosetta ATCC50818, Salpingoeca rosetta Dayel et al. 2011, Salpingoeca sp. ATCC 50818, Salpingoeca sp. ATCC50818

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCM7	PTSG_01195	F2TZZ7	F2U132	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Minichromosomal maintenance factor; Belongs to the MCM family.	0.999
MCM7	PTSG_01203	F2TZZ7	F2U140	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Mcm10 domain-containing protein.	0.994
MCM7	PTSG_01490	F2TZZ7	F2U0H7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	RPA_C domain-containing protein.	0.806
MCM7	PTSG_02565	F2TZZ7	F2U2N4	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Minichromosome maintenance protein 8; Belongs to the MCM family.	0.954
MCM7	PTSG_04052	F2TZZ7	F2U7M8	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.753
MCM7	PTSG_04316	F2TZZ7	F2U872	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	PTSG_05019	F2TZZ7	F2U9A1	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Uncharacterized protein.	0.400
MCM7	PTSG_05144	F2TZZ7	F2UAM4	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.400
MCM7	PTSG_07071	F2TZZ7	F2UDZ1	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	PTSG_08033	F2TZZ7	F2UHT3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA replication licensing factor MCM9; Belongs to the MCM family.	0.988
MCM7	PTSG_10945	F2TZZ7	F2US92	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.400
MCM7	PTSG_10947	F2TZZ7	F2US95	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Replication protein A subunit.	0.755
MCM7	PTSG_11588	F2TZZ7	F2TWK1	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	PTSG_11661	F2TZZ7	F2TXY4	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.648
MCM7	PTSG_12543	F2TZZ7	F2UEA6	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
PTSG_00566	PTSG_01222	F2TWU7	F2U160	S1 motif domain-containing protein.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.999
PTSG_00566	PTSG_04225	F2TWU7	F2U6Y5	S1 motif domain-containing protein.	S1 motif domain-containing protein.	0.935
PTSG_00566	PTSG_05411	F2TWU7	F2UAC9	S1 motif domain-containing protein.	Uncharacterized protein.	0.471
PTSG_00566	PTSG_08790	F2TWU7	F2UKP9	S1 motif domain-containing protein.	TYR_PHOSPHATASE_2 domain-containing protein.	0.736
PTSG_00566	PTSG_11661	F2TWU7	F2TXY4	S1 motif domain-containing protein.	DNA ligase.	0.944

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