(52 nodes) Phosphatidylinositol signaling system network (Salpingoeca rosetta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTSG_00008	PIPK domain-containing protein. (243 aa)
	PTSG_00009	PIPK domain-containing protein. (357 aa)
	PTSG_00581	Uncharacterized protein. (149 aa)
	PTSG_01584	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1309 aa)
	PTSG_01614	Calmodulin. (143 aa)
	PTSG_01647	Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (329 aa)
	PTSG_01664	Myotubularin phosphatase domain-containing protein. (419 aa)
	PTSG_01705	Uncharacterized protein. (111 aa)
	PTSG_11778	Uncharacterized protein. (146 aa)
	PTSG_01192	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha. (1006 aa)
	PTSG_02105	Inositol-1-monophosphatase. (281 aa)
	PTSG_02155	Kinase; Belongs to the inositol phosphokinase (IPK) family. (388 aa)
	PTSG_11860	Uncharacterized protein. (271 aa)
	PTSG_02362	Phosphoinositide phospholipase C. (963 aa)
	PTSG_02403	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (206 aa)
	PTSG_02412	Uncharacterized protein. (1147 aa)
	PTSG_02075	Phosphoinositide 3-kinase; Belongs to the PI3/PI4-kinase family. (883 aa)
	PTSG_02873	IPPc domain-containing protein. (675 aa)
	PTSG_03091	Uncharacterized protein. (144 aa)
	PTSG_03792	Calmodulin. (136 aa)
	PTSG_03830	Phosphoinositide phospholipase C. (1321 aa)
	PTSG_04801	Uncharacterized protein. (952 aa)
	PTSG_04821	Uncharacterized protein. (149 aa)
	PTSG_05114	Pik4ca protein; Belongs to the PI3/PI4-kinase family. (1924 aa)
	PTSG_05582	Inositol polyphosphate-5-phosphatase. (462 aa)
	PTSG_05649	Uncharacterized protein. (106 aa)
	PTSG_06340	Calmodulin; Belongs to the calmodulin family. (149 aa)
	PTSG_05869	Uncharacterized protein. (784 aa)
	PTSG_05905	Calmodulin 1. (171 aa)
	PTSG_12561	IPPc domain-containing protein. (1392 aa)
	PTSG_06711	Phosphatidate cytidylyltransferase; Belongs to the CDS family. (432 aa)
	PTSG_06567	SAC domain-containing protein. (407 aa)
	PTSG_07791	SH2 domain-containing protein. (1053 aa)
	PTSG_12655	Uncharacterized protein. (2898 aa)
	PTSG_07403	Diacylglycerol kinase. (1206 aa)
	PTSG_12579	CDP-diacylglycerol--inositol 3-phosphatidyltransferase. (231 aa)
	PTSG_08277	Kinase; Belongs to the inositol phosphokinase (IPK) family. (375 aa)
	PTSG_08619	SAC domain-containing protein. (1224 aa)
	PTSG_09606	Phosphoinositide phospholipase C. (1174 aa)
	PTSG_09611	Non-specific serine/threonine protein kinase. (727 aa)
	PTSG_09301	Phosphoinositide-3-kinase catalytic gamma polypeptide; Belongs to the PI3/PI4-kinase family. (1916 aa)
	PTSG_09381	Phosphatidylinositol kinase. (396 aa)
	PTSG_12885	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (867 aa)
	PTSG_09229	EF-hand domain-containing protein. (155 aa)
	PTSG_09234	Myotubularin. (656 aa)
	PTSG_09259	Diacylglycerol kinase. (1091 aa)
	PTSG_10021	IPPc domain-containing protein. (509 aa)
	PTSG_10376	Uncharacterized protein. (869 aa)
	PTSG_10560	Uncharacterized protein. (415 aa)
	PTSG_11094	Kinase; Belongs to the histidine acid phosphatase family. (1344 aa)
	PTSG_11029	Pik4cb protein; Belongs to the PI3/PI4-kinase family. (933 aa)
	PTSG_13185	Uncharacterized protein. (142 aa)

Your Current Organism:

Salpingoeca rosetta

NCBI taxonomy Id: 946362
Other names: Proterospongia sp. ATCC 50818, S. rosetta, Salpingoeca rosetta ATCC 50818, Salpingoeca rosetta ATCC50818, Salpingoeca rosetta Dayel et al. 2011, Salpingoeca sp. ATCC 50818, Salpingoeca sp. ATCC50818

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PTSG_00008	PTSG_00009	F2TV96	F2TV97	PIPK domain-containing protein.	PIPK domain-containing protein.	0.901
PTSG_00008	PTSG_01192	F2TV96	F2U129	PIPK domain-containing protein.	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha.	0.900
PTSG_00008	PTSG_01664	F2TV96	F2TYL0	PIPK domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.900
PTSG_00008	PTSG_02075	F2TV96	F2U2K1	PIPK domain-containing protein.	Phosphoinositide 3-kinase; Belongs to the PI3/PI4-kinase family.	0.920
PTSG_00008	PTSG_02362	F2TV96	F2U1Z4	PIPK domain-containing protein.	Phosphoinositide phospholipase C.	0.932
PTSG_00008	PTSG_02412	F2TV96	F2U247	PIPK domain-containing protein.	Uncharacterized protein.	0.900
PTSG_00008	PTSG_02873	F2TV96	F2U3K6	PIPK domain-containing protein.	IPPc domain-containing protein.	0.904
PTSG_00008	PTSG_03830	F2TV96	F2U5I3	PIPK domain-containing protein.	Phosphoinositide phospholipase C.	0.922
PTSG_00008	PTSG_04801	F2TV96	F2U9R0	PIPK domain-containing protein.	Uncharacterized protein.	0.913
PTSG_00008	PTSG_05114	F2TV96	F2UAJ9	PIPK domain-containing protein.	Pik4ca protein; Belongs to the PI3/PI4-kinase family.	0.527
PTSG_00008	PTSG_05869	F2TV96	F2UD10	PIPK domain-containing protein.	Uncharacterized protein.	0.915
PTSG_00008	PTSG_08619	F2TV96	F2UK72	PIPK domain-containing protein.	SAC domain-containing protein.	0.917
PTSG_00008	PTSG_09234	F2TV96	F2UN43	PIPK domain-containing protein.	Myotubularin.	0.914
PTSG_00008	PTSG_09606	F2TV96	F2ULH4	PIPK domain-containing protein.	Phosphoinositide phospholipase C.	0.912
PTSG_00008	PTSG_10021	F2TV96	F2UPA0	PIPK domain-containing protein.	IPPc domain-containing protein.	0.904
PTSG_00008	PTSG_10376	F2TV96	F2UR48	PIPK domain-containing protein.	Uncharacterized protein.	0.900
PTSG_00008	PTSG_10560	F2TV96	F2URQ0	PIPK domain-containing protein.	Uncharacterized protein.	0.912
PTSG_00008	PTSG_11029	F2TV96	F2USH5	PIPK domain-containing protein.	Pik4cb protein; Belongs to the PI3/PI4-kinase family.	0.553
PTSG_00008	PTSG_12561	F2TV96	F2UEG5	PIPK domain-containing protein.	IPPc domain-containing protein.	0.906
PTSG_00008	PTSG_12655	F2TV96	F2UGR5	PIPK domain-containing protein.	Uncharacterized protein.	0.918

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