(26 nodes) HDR through Homologous Recombination (HRR), and Sensing of DNA Double Strand Breaks network (Besnoitia besnoiti)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	BESB_030630	Uncharacterized protein. (290 aa)
	BESB_029200	3'-5' exonuclease domain-containing protein. (642 aa)
	BESB_018170	ATP-dependent DNA helicase, RecQ family protein. (1677 aa)
	BESB_085170	Uncharacterized protein. (651 aa)
	BESB_077250	RecF/RecN/SMC N terminal domain-containing protein. (1603 aa)
	BESB_012460	XPA_C domain-containing protein. (199 aa)
	BESB_027980	Mre11 DNA-binding domain-containing protein. (1201 aa)
	BESB_028350	Uncharacterized protein. (2896 aa)
	BESB_028370	Toprim domain-containing protein. (1604 aa)
	BESB_017590	ERCC4 domain-containing protein. (2024 aa)
	BESB_024390	Uncharacterized protein. (519 aa)
	BESB_060120	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (789 aa)
	BESB_076070	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (6188 aa)
	BESB_047800	RMI1_N domain-containing protein. (615 aa)
	BESB_064970	XPG N-terminal domain-containing protein. (2012 aa)
	BESB_047870	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (835 aa)
	BESB_066030	OB-fold nucleic acid binding domain-containing protein. (515 aa)
	BESB_069160	Meiotic recombination protein DMC1 family protein; Belongs to the RecA family. (349 aa)
	BESB_002290	ERCC4 domain-containing protein. (1377 aa)
	BESB_004290	DNA repair protein rad10 subfamily protein. (373 aa)
	BESB_054470	RMI1_N domain-containing protein. (835 aa)
	BESB_046480	BRCA-2_OB1 domain-containing protein. (4044 aa)
	BESB_048180	ATP-dependent DNA helicase, RecQ family protein. (1632 aa)
	BESB_038190	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (352 aa)
	BESB_036910	Replication protein A subunit. (786 aa)
	BESB_004930	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (7366 aa)

Your Current Organism:

Besnoitia besnoiti

NCBI taxonomy Id: 94643
Other names: B. besnoiti

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BESB_002290	BESB_004290	A0A2A9MH78	A0A2A9MHS0	ERCC4 domain-containing protein.	DNA repair protein rad10 subfamily protein.	0.981
BESB_002290	BESB_004930	A0A2A9MH78	A0A2A9MQA6	ERCC4 domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.788
BESB_002290	BESB_012460	A0A2A9MH78	A0A2A9M611	ERCC4 domain-containing protein.	XPA_C domain-containing protein.	0.952
BESB_002290	BESB_017590	A0A2A9MH78	A0A2A9M826	ERCC4 domain-containing protein.	ERCC4 domain-containing protein.	0.963
BESB_002290	BESB_018170	A0A2A9MH78	A0A2A9M3H8	ERCC4 domain-containing protein.	ATP-dependent DNA helicase, RecQ family protein.	0.921
BESB_002290	BESB_024390	A0A2A9MH78	A0A2A9M8I7	ERCC4 domain-containing protein.	Uncharacterized protein.	0.921
BESB_002290	BESB_027980	A0A2A9MH78	A0A2A9M6V4	ERCC4 domain-containing protein.	Mre11 DNA-binding domain-containing protein.	0.822
BESB_002290	BESB_028350	A0A2A9MH78	A0A2A9M7M8	ERCC4 domain-containing protein.	Uncharacterized protein.	0.730
BESB_002290	BESB_028370	A0A2A9MH78	A0A2A9M7R5	ERCC4 domain-containing protein.	Toprim domain-containing protein.	0.871
BESB_002290	BESB_029200	A0A2A9MH78	A0A2A9M0I3	ERCC4 domain-containing protein.	3'-5' exonuclease domain-containing protein.	0.995
BESB_002290	BESB_030630	A0A2A9MH78	A0A2A9LZN2	ERCC4 domain-containing protein.	Uncharacterized protein.	0.772
BESB_002290	BESB_036910	A0A2A9MH78	A0A2A9MN20	ERCC4 domain-containing protein.	Replication protein A subunit.	0.840
BESB_002290	BESB_038190	A0A2A9MH78	A0A2A9MLY1	ERCC4 domain-containing protein.	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily.	0.972
BESB_002290	BESB_046480	A0A2A9MH78	A0A2A9MKE7	ERCC4 domain-containing protein.	BRCA-2_OB1 domain-containing protein.	0.775
BESB_002290	BESB_047800	A0A2A9MH78	A0A2A9MDK6	ERCC4 domain-containing protein.	RMI1_N domain-containing protein.	0.890
BESB_002290	BESB_047870	A0A2A9MH78	A0A2A9MF34	ERCC4 domain-containing protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.888
BESB_002290	BESB_048180	A0A2A9MH78	A0A2A9MKU4	ERCC4 domain-containing protein.	ATP-dependent DNA helicase, RecQ family protein.	0.921
BESB_002290	BESB_054470	A0A2A9MH78	A0A2A9MIK6	ERCC4 domain-containing protein.	RMI1_N domain-containing protein.	0.890
BESB_002290	BESB_060120	A0A2A9MH78	A0A2A9MAW4	ERCC4 domain-containing protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.871
BESB_002290	BESB_064970	A0A2A9MH78	A0A2A9MEU4	ERCC4 domain-containing protein.	XPG N-terminal domain-containing protein.	0.965