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dnaJ dnaJ OHU18162.1 OHU18162.1 rnj rnj nrdR nrdR OHU19256.1 OHU19256.1 OHU19108.1 OHU19108.1 uvrA uvrA OHU19060.1 OHU19060.1 hisI hisI hisD hisD ileS ileS ribBA ribBA OHU18898.1 OHU18898.1 priA priA pyrC pyrC alaS alaS OHU19361.1 OHU19361.1 mutM mutM gltX gltX OHU22494.1 OHU22494.1 OHU22431.1 OHU22431.1 cobB cobB OHU22378.1 OHU22378.1 OHU22908.1 OHU22908.1 OHU22257.1 OHU22257.1 add add OHU22190.1 OHU22190.1 OHU22862.1 OHU22862.1 rpsN rpsN rpoC rpoC htpX htpX OHU21911.1 OHU21911.1 mtcA1 mtcA1 thiC thiC OHU22794.1 OHU22794.1 dnaJ-2 dnaJ-2 OHU21635.1 OHU21635.1 OHU21593.1 OHU21593.1 OHU21574.1 OHU21574.1 OHU21502.1 OHU21502.1 OHU21497.1 OHU21497.1 metE metE OHU22743.1 OHU22743.1 OHU21360.1 OHU21360.1 OHU21163.1 OHU21163.1 OHU21127.1 OHU21127.1 OHU21067.1 OHU21067.1 tadA tadA OHU22658.1 OHU22658.1 OHU20937.1 OHU20937.1 OHU20825.1 OHU20825.1 ftsH ftsH folE folE OHU20780.1 OHU20780.1 cysS cysS OHU26823.1 OHU26823.1 OHU26888.1 OHU26888.1 mshC mshC BKG76_07095 BKG76_07095 OHU31500.1 OHU31500.1 OHU31138.1 OHU31138.1 OHU31120.1 OHU31120.1 OHU31051.1 OHU31051.1 mca mca mshB mshB OHU30680.1 OHU30680.1 OHU30595.1 OHU30595.1 OHU30592.1 OHU30592.1 clpX clpX ybeY ybeY dnaG dnaG OHU31360.1 OHU31360.1 OHU31355.1 OHU31355.1 OHU31337.1 OHU31337.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaJMolecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (381 aa)
OHU18162.1Carbonic anhydrase; Derived by automated computational analysis using gene prediction method: Protein Homology. (749 aa)
rnjRibonuclease J; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (563 aa)
nrdRTranscriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (154 aa)
OHU19256.1Transcriptional repressor; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Fur family. (152 aa)
OHU19108.1DNA-3-methyladenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (493 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (984 aa)
OHU19060.1PIG-L family deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (116 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (449 aa)
ileSisoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1072 aa)
ribBABifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (417 aa)
OHU18898.1Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (340 aa)
priAPrimosome assembly protein PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (671 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (433 aa)
alaSalanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (891 aa)
OHU19361.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (373 aa)
mutMDNA-formamidopyrimidine glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (286 aa)
gltXglutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (500 aa)
OHU22494.1Methionine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa)
OHU22431.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
cobBNAD-dependent deacylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sirtuin family. Class III subfamily. (248 aa)
OHU22378.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
OHU22908.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
OHU22257.1Mannose-6-phosphate isomerase, class I; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
addAdenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (362 aa)
OHU22190.1Cytidine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
OHU22862.1Type VII secretion protein EccE; Derived by automated computational analysis using gene prediction method: Protein Homology. (544 aa)
rpsN30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rpoCDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1315 aa)
htpXZinc metalloprotease HtpX; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase M48B family. (290 aa)
OHU21911.1Mycothiol conjugate amidase Mca; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
mtcA1Carbonic anhydrase; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (546 aa)
OHU22794.1Class II fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (347 aa)
dnaJ-2Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (394 aa)
OHU21635.1Aryl-alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa)
OHU21593.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
OHU21574.1RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (110 aa)
OHU21502.1Metallopeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (494 aa)
OHU21497.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (756 aa)
OHU22743.1Galactose-1-phosphate uridylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
OHU21360.1DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPG family. (254 aa)
OHU21163.1tRNA-specific adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
OHU21127.1PHP domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa)
OHU21067.1Cold-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (578 aa)
tadAtRNA-specific adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (152 aa)
OHU22658.1tRNA glutamyl-Q(34) synthetase GluQRS; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
OHU20937.1Transcriptional repressor; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Fur family. (142 aa)
OHU20825.1Peptidase M1; Derived by automated computational analysis using gene prediction method: Protein Homology. (450 aa)
ftsHCell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (755 aa)
folEGTP cyclohydrolase I FolE; Derived by automated computational analysis using gene prediction method: Protein Homology. (204 aa)
OHU20780.1Carbonic anhydrase; Derived by automated computational analysis using gene prediction method: Protein Homology. (204 aa)
cysScysteine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (470 aa)
OHU26823.1Anti-sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
OHU26888.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1251 aa)
mshCcysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. (416 aa)
BKG76_07095stearoyl-CoA 9-desaturase; Incomplete; too short partial abutting assembly gap; missing start and stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (153 aa)
OHU31500.1M18 family aminopeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
OHU31138.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa)
OHU31120.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
OHU31051.1Endonuclease VIII; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPG family. (287 aa)
mcaMycothiol conjugate amidase Mca; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily. (289 aa)
mshBN-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway. (278 aa)
OHU30680.1Peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
OHU30595.1Derived by automated computational analysis using gene prediction method: Protein Homology. (853 aa)
OHU30592.1DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPG family. (265 aa)
clpXATP-dependent protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (426 aa)
ybeYrRNA maturation RNase YbeY; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (170 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (634 aa)
OHU31360.1D-alanyl-D-alanine dipeptidase; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. (217 aa)
OHU31355.1S-(hydroxymethyl)mycothiol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa)
OHU31337.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
Your Current Organism:
Mycobacteroides franklinii
NCBI taxonomy Id: 948102
Other names: ATCC BAA-2149, DSM 45524, M. franklinii, Mycobacterium franklinii, Mycobacterium franklinii Nogueira et al. 2015, Mycobacterium sp. CV02, Mycobacteroides franklinii (Nogueira et al. 2015) Gupta et al. 2018, strain CV002
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