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OHU18939.1 OHU18939.1 bioA bioA OHU19003.1 OHU19003.1 bioD bioD bioB bioB OHU19135.1 OHU19135.1 OHU19278.1 OHU19278.1 OHU18171.1 OHU18171.1 OHU18202.1 OHU18202.1 cobB-2 cobB-2 OHU18212.1 OHU18212.1 cobQ cobQ panB panB cobS cobS cobT cobT OHU30357.1 OHU30357.1 cobD cobD OHU18907.1 OHU18907.1 OHU31389.1 OHU31389.1 OHU31400.1 OHU31400.1 OHU30928.1 OHU30928.1 OHU31459.1 OHU31459.1 OHU31043.1 OHU31043.1 OHU31052.1 OHU31052.1 pdxH pdxH OHU31160.1 OHU31160.1 serC serC OHU31269.1 OHU31269.1 OHU26848.1 OHU26848.1 OHU26849.1 OHU26849.1 OHU26903.1 OHU26903.1 OHU26850.1 OHU26850.1 OHU26851.1 OHU26851.1 OHU26853.1 OHU26853.1 panD panD panC panC OHU20799.1 OHU20799.1 OHU20800.1 OHU20800.1 OHU20801.1 OHU20801.1 OHU20947.1 OHU20947.1 OHU20956.1 OHU20956.1 OHU21119.1 OHU21119.1 OHU21296.1 OHU21296.1 OHU21371.1 OHU21371.1 thiE thiE OHU22799.1 OHU22799.1 OHU21744.1 OHU21744.1 thiG thiG OHU21759.1 OHU21759.1 thiC thiC OHU22051.1 OHU22051.1 OHU22059.1 OHU22059.1 OHU22395.1 OHU22395.1 OHU22449.1 OHU22449.1 OHU22521.1 OHU22521.1 thiL thiL dxs dxs OHU18764.1 OHU18764.1 OHU18790.1 OHU18790.1 OHU18792.1 OHU18792.1 pdxS pdxS pdxT pdxT OHU18898.1 OHU18898.1 OHU30486.1 OHU30486.1 ribBA ribBA ribH ribH OHU18910.1 OHU18910.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OHU18939.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (110 aa)
bioAAdenosylmethionine--8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (454 aa)
OHU19003.18-amino-7-oxononanoate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (225 aa)
bioBBiotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (336 aa)
OHU19135.1Thiamine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (394 aa)
OHU19278.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
OHU18171.1Riboflavin biosynthesis protein RibF; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (320 aa)
OHU18202.1uroporphyrinogen-III C-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
cobB-2Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (443 aa)
OHU18212.1cob(I)yrinic acid a,c-diamide adenosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (204 aa)
cobQCobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (504 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (281 aa)
cobSadenosylcobinamide-GDP ribazoletransferase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (252 aa)
cobTNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (352 aa)
OHU30357.1Adenosylcobinamide kinase/adenosylcobinamide phosphate guanyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
cobDCobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (314 aa)
OHU18907.1Riboflavin synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
OHU31389.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
OHU31400.1ATP:cob(I)alamin adenosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Cob(I)alamin adenosyltransferase family. (191 aa)
OHU30928.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (129 aa)
OHU31459.1Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
OHU31043.1Cobalamin biosynthesis protein CobW; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
OHU31052.1precorrin-6A synthase (deacetylating); Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (215 aa)
OHU31160.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (154 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (371 aa)
OHU31269.14-amino-4-deoxychorismate lyase; Catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
OHU26848.1Cobalamin biosynthesis bifunctional protein CbiET; Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa)
OHU26849.1Precorrin-4 C(11)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
OHU26903.1cobalt-precorrin-6A reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
OHU26850.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the precorrin methyltransferase family. (492 aa)
OHU26851.1precorrin-8X methylmutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
OHU26853.1Cobaltochelatase subunit CobN; Derived by automated computational analysis using gene prediction method: Protein Homology. (1211 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (140 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (310 aa)
OHU20799.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
OHU20800.1Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (126 aa)
OHU20801.1Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (350 aa)
OHU20947.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
OHU20956.1Glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa)
OHU21119.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
OHU21296.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (334 aa)
OHU21371.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (133 aa)
thiEThiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (223 aa)
OHU22799.1Glycine oxidase ThiO; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
OHU21744.1Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology. (65 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (262 aa)
OHU21759.1Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (546 aa)
OHU22051.1Mycofactocin system creatininase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
OHU22059.1Pyridoxamine 5'-phosphate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
OHU22395.1Cobalamin biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
OHU22449.1SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
OHU22521.1Aspartate aminotransferase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (461 aa)
thiLThiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (313 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (641 aa)
OHU18764.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa)
OHU18790.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (342 aa)
OHU18792.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (304 aa)
pdxTGlutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (193 aa)
OHU18898.1Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (340 aa)
OHU30486.1Aspartate aminotransferase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (464 aa)
ribBABifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (417 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (160 aa)
OHU18910.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (147 aa)
Your Current Organism:
Mycobacteroides franklinii
NCBI taxonomy Id: 948102
Other names: ATCC BAA-2149, DSM 45524, M. franklinii, Mycobacterium franklinii, Mycobacterium franklinii Nogueira et al. 2015, Mycobacterium sp. CV02, Mycobacteroides franklinii (Nogueira et al. 2015) Gupta et al. 2018, strain CV002
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