STRINGSTRING
OHU18950.1 OHU18950.1 carB carB carA carA OHU18880.1 OHU18880.1 pdxT pdxT OHU22554.1 OHU22554.1 leuD leuD leuC leuC leuB leuB OHU22539.1 OHU22539.1 ilvC ilvC OHU22525.1 OHU22525.1 OHU22524.1 OHU22524.1 OHU22494.1 OHU22494.1 OHU22934.1 OHU22934.1 OHU22444.1 OHU22444.1 OHU22926.1 OHU22926.1 OHU22919.1 OHU22919.1 OHU22360.1 OHU22360.1 OHU22299.1 OHU22299.1 OHU22298.1 OHU22298.1 OHU22291.1 OHU22291.1 OHU22905.1 OHU22905.1 sseA_1 sseA_1 OHU22204.1 OHU22204.1 OHU22179.1 OHU22179.1 metXA metXA folD folD guaA guaA OHU22141.1 OHU22141.1 OHU22140.1 OHU22140.1 glmS glmS OHU22862.1 OHU22862.1 OHU22092.1 OHU22092.1 OHU22078.1 OHU22078.1 OHU22852.1 OHU22852.1 OHU22851.1 OHU22851.1 mtnP mtnP OHU21932.1 OHU21932.1 proC proC dtd dtd OHU21730.1 OHU21730.1 metZ metZ OHU21647.1 OHU21647.1 OHU21613.1 OHU21613.1 OHU21516.1 OHU21516.1 OHU21515.1 OHU21515.1 ilvD ilvD OHU21444.1 OHU21444.1 metE metE OHU21435.1 OHU21435.1 OHU21351.1 OHU21351.1 OHU21307.1 OHU21307.1 OHU21306.1 OHU21306.1 OHU21272.1 OHU21272.1 trpG trpG OHU21148.1 OHU21148.1 OHU21132.1 OHU21132.1 gltD gltD OHU21118.1 OHU21118.1 pheA pheA OHU21097.1 OHU21097.1 serS serS OHU21026.1 OHU21026.1 OHU21025.1 OHU21025.1 OHU21023.1 OHU21023.1 OHU21006.1 OHU21006.1 OHU22661.1 OHU22661.1 OHU20962.1 OHU20962.1 OHU20956.1 OHU20956.1 leuA leuA OHU20942.1 OHU20942.1 asd asd egtC egtC egtD egtD OHU20877.1 OHU20877.1 OHU22634.1 OHU22634.1 panD panD OHU26875.1 OHU26875.1 OHU26852.1 OHU26852.1 OHU26897.1 OHU26897.1 OHU26888.1 OHU26888.1 OHU26767.1 OHU26767.1 OHU26763.1 OHU26763.1 purQ purQ purF purF OHU31273.1 OHU31273.1 OHU31255.1 OHU31255.1 OHU31207.1 OHU31207.1 serC serC OHU31145.1 OHU31145.1 OHU31048.1 OHU31048.1 OHU31042.1 OHU31042.1 OHU31016.1 OHU31016.1 arcA_1 arcA_1 OHU30984.1 OHU30984.1 lysA-2 lysA-2 OHU31436.1 OHU31436.1 OHU30921.1 OHU30921.1 OHU30919.1 OHU30919.1 cbs cbs OHU30911.1 OHU30911.1 OHU31435.1 OHU31435.1 glyA glyA OHU30868.1 OHU30868.1 OHU30847.1 OHU30847.1 OHU31417.1 OHU31417.1 OHU30798.1 OHU30798.1 dapD dapD OHU30794.1 OHU30794.1 lysA lysA OHU30717.1 OHU30717.1 OHU30716.1 OHU30716.1 thrB thrB OHU30680.1 OHU30680.1 cysO cysO cysM cysM OHU31384.1 OHU31384.1 proB proB proA proA cysH cysH OHU30384.1 OHU30384.1 OHU31342.1 OHU31342.1 glnA_2 glnA_2 gcvT gcvT OHU30361.1 OHU30361.1 OHU30351.1 OHU30351.1 trpD trpD OHU30326.1 OHU30326.1 OHU31648.1 OHU31648.1 cobQ cobQ cobB-2 cobB-2 OHU18164.1 OHU18164.1 dapB dapB folA folA dapA dapA OHU18264.1 OHU18264.1 OHU18262.1 OHU18262.1 dapF dapF gcvH gcvH gcvP gcvP OHU19271.1 OHU19271.1 OHU19247.1 OHU19247.1 OHU19240.1 OHU19240.1 OHU19237.1 OHU19237.1 OHU19236.1 OHU19236.1 ilvD-2 ilvD-2 OHU19200.1 OHU19200.1 pyrG pyrG argH argH argG argG argR argR OHU19115.1 OHU19115.1 argD argD argB argB argJ argJ argC argC OHU19091.1 OHU19091.1 trpA trpA trpB trpB trpC trpC trpE trpE priA-2 priA-2 hisH hisH ilvA ilvA OHU19391.1 OHU19391.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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OHU18950.1Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (417 aa)
carBCarbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family. (1112 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (376 aa)
OHU18880.1Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
pdxTGlutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (193 aa)
OHU22554.1Cystathionine gamma-lyase; Catalyzes the formation of cysteine and 2-oxobutanoate from cystathionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (199 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (480 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (337 aa)
OHU22539.1Phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
OHU22525.1Acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (167 aa)
OHU22524.1Acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (617 aa)
OHU22494.1Methionine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa)
OHU22934.1Dihydrodipicolinate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (369 aa)
OHU22444.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
OHU22926.1Phosphoserine phosphatase SerB; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
OHU22919.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
OHU22360.1Acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (547 aa)
OHU22299.1TIGR02569 family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
OHU22298.1Adenylyltransferase/sulfurtransferase MoeZ; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
OHU22291.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
OHU22905.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (445 aa)
sseA_1Sulfurtransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
OHU22204.1N-acyl-L-amino acid amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
OHU22179.1Bifunctional o-acetylhomoserine/o-acetylserine sulfhydrylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (442 aa)
metXAHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (365 aa)
folDBifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (281 aa)
guaAGlutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. (522 aa)
OHU22141.1Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (397 aa)
OHU22140.1Glutamate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the group II decarboxylase family. (472 aa)
glmSGlutamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (621 aa)
OHU22862.1Type VII secretion protein EccE; Derived by automated computational analysis using gene prediction method: Protein Homology. (544 aa)
OHU22092.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (424 aa)
OHU22078.1Glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (450 aa)
OHU22852.1N-dimethylarginine dimethylaminohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
OHU22851.1Ornithine--oxo-acid transaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (406 aa)
mtnPMethylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (257 aa)
OHU21932.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (299 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (143 aa)
OHU21730.1GNAT family N-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (410 aa)
OHU21647.1Hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (317 aa)
OHU21613.1Tartrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
OHU21516.1acetyl/propionyl-CoA carboxylase subuit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (653 aa)
OHU21515.1methylcrotonoyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (525 aa)
ilvDDihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (567 aa)
OHU21444.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (756 aa)
OHU21435.1Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
OHU21351.1Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa)
OHU21307.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (83 aa)
OHU21306.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (142 aa)
OHU21272.1Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
trpGAminodeoxychorismate/anthranilate synthase component II; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
OHU21148.1Sulfurtransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (278 aa)
OHU21132.1Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1534 aa)
gltDGlutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (488 aa)
OHU21118.1L-gulono-1,4-lactone oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
pheAPrephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (308 aa)
OHU21097.1Pyruvate oxidase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (579 aa)
serSserine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (418 aa)
OHU21026.13-isopropylmalate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
OHU21025.13-isopropylmalate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LeuD family. (184 aa)
OHU21023.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (629 aa)
OHU21006.1Dihydrodipicolinate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
OHU22661.1Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
OHU20962.1Aminoglycoside phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
OHU20956.1Glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (608 aa)
OHU20942.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (421 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (345 aa)
egtCErgothioneine biosynthesis protein EgtC; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. (226 aa)
egtDDimethylhistidine N-methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (318 aa)
OHU20877.1Lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
OHU22634.1Inhibition of morphological differentiation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (140 aa)
OHU26875.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (536 aa)
OHU26852.1precorrin-3B synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
OHU26897.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (566 aa)
OHU26888.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1251 aa)
OHU26767.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (451 aa)
OHU26763.1Glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (450 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (224 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (504 aa)
OHU31273.1Dihydrodipicolinate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
OHU31255.1Sulfurtransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
OHU31207.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (371 aa)
OHU31145.1Aminoglycoside phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
OHU31048.1Dihydrodipicolinate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
OHU31042.1Dihydrodipicolinate synthase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DapA family. (295 aa)
OHU31016.1acetyl-CoA carboxylase carboxyltransferase subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (531 aa)
arcA_1Arginine deiminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
OHU30984.1GNAT family N-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
lysA-2Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (448 aa)
OHU31436.13-hydroxyisobutyrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HIBADH-related family. (293 aa)
OHU30921.13-hydroxyisobutyryl-CoA hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa)
OHU30919.1Methylmalonate-semialdehyde dehydrogenase (acylating); Derived by automated computational analysis using gene prediction method: Protein Homology. (505 aa)
cbsCystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
OHU30911.1Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
OHU31435.1Threonine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (414 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (487 aa)
OHU30868.1Alanine racemase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
OHU30847.1Pyridoxal-5'-phosphate-dependent protein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
OHU31417.11-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (556 aa)
OHU30798.1Proline dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (315 aa)
OHU30794.1Succinyl-diaminopimelate desuccinylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (470 aa)
OHU30717.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (437 aa)
OHU30716.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (355 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (339 aa)
OHU30680.1Peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
cysOMolybdopterin synthase sulfur carrier subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (90 aa)
cysMCysteine synthase B; Catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
OHU31384.1NAD-glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1556 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (368 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (438 aa)
cysHPhosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (240 aa)
OHU30384.1Type I glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (446 aa)
OHU31342.1Benzoylformate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (537 aa)
glnA_2Type I glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (368 aa)
OHU30361.1Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
OHU30351.1Asparagine synthase (glutamine-hydrolyzing); Derived by automated computational analysis using gene prediction method: Protein Homology. (642 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (355 aa)
OHU30326.1Methylenetetrahydrofolate reductase [NAD(P)H]; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (326 aa)
OHU31648.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa)
cobQCobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (504 aa)
cobB-2Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (443 aa)
OHU18164.1Alanine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the AlaDH/PNT family. (371 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (227 aa)
folADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (163 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (281 aa)
OHU18264.1N-acetylglutamate synthase; Catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetyltransferase family. (162 aa)
OHU18262.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (295 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (131 aa)
gcvPGlycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (945 aa)
OHU19271.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
OHU19247.1Sulfite reductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (580 aa)
OHU19240.1Sulfite reductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (538 aa)
OHU19237.13-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (214 aa)
OHU19236.13-isopropylmalate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (466 aa)
ilvD-2Dihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (600 aa)
OHU19200.1Molybdopterin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (1376 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (568 aa)
argHArgininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
argGArgininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa)
argRArginine repressor; Regulates arginine biosynthesis genes. (162 aa)
OHU19115.1Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (312 aa)
argDAspartate aminotransferase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (401 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (290 aa)
argJBifunctional ornithine acetyltransferase/N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (404 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (347 aa)
OHU19091.1Peptidase M20; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (262 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (419 aa)
trpCIndole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. (272 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (511 aa)
priA-2Phosphoribosyl isomerase A; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (243 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (413 aa)
OHU19391.1L-asparaginase; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa)
Your Current Organism:
Mycobacteroides franklinii
NCBI taxonomy Id: 948102
Other names: ATCC BAA-2149, DSM 45524, M. franklinii, Mycobacterium franklinii, Mycobacterium franklinii Nogueira et al. 2015, Mycobacterium sp. CV02, Mycobacteroides franklinii (Nogueira et al. 2015) Gupta et al. 2018, strain CV002
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