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thyA thyA OHU18211.1 OHU18211.1 pyrH pyrH OHU18240.1 OHU18240.1 OHU22564.1 OHU22564.1 OHU30396.1 OHU30396.1 OHU30515.1 OHU30515.1 ndk ndk OHU30573.1 OHU30573.1 OHU30598.1 OHU30598.1 OHU30626.1 OHU30626.1 OHU30738.1 OHU30738.1 OHU30788.1 OHU30788.1 OHU31415.1 OHU31415.1 fas6_1 fas6_1 OHU30809.1 OHU30809.1 OHU31033.1 OHU31033.1 OHU31102.1 OHU31102.1 OHU31149.1 OHU31149.1 OHU31486.1 OHU31486.1 OHU31304.1 OHU31304.1 OHU28951.1 OHU28951.1 pyrD pyrD OHU20969.1 OHU20969.1 tgt tgt tadA tadA OHU21222.1 OHU21222.1 OHU21340.1 OHU21340.1 OHU21470.1 OHU21470.1 OHU21505.1 OHU21505.1 dcd dcd OHU21701.1 OHU21701.1 pyrE pyrE OHU21761.1 OHU21761.1 OHU21858.1 OHU21858.1 OHU21876.1 OHU21876.1 OHU21921.1 OHU21921.1 groS groS OHU22190.1 OHU22190.1 OHU22191.1 OHU22191.1 upp upp OHU22881.1 OHU22881.1 OHU22222.1 OHU22222.1 OHU22225.1 OHU22225.1 tmk tmk OHU22400.1 OHU22400.1 nrdI nrdI OHU22402.1 OHU22402.1 nrdF2 nrdF2 OHU22537.1 OHU22537.1 dut dut OHU18783.1 OHU18783.1 pyrR pyrR pyrB pyrB pyrC pyrC OHU18880.1 OHU18880.1 carA carA carB carB pyrF pyrF OHU18891.1 OHU18891.1 OHU18892.1 OHU18892.1 pyrG pyrG cmk cmk OHU19144.1 OHU19144.1 OHU19179.1 OHU19179.1 nrdR nrdR thyX thyX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (266 aa)
OHU18211.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa)
OHU18240.1Aminodeoxychorismate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
OHU22564.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
OHU30396.1HNH endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
OHU30515.1Cytidine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (108 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (136 aa)
OHU30573.1Transglycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (106 aa)
OHU30598.1HNH endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa)
OHU30626.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
OHU30738.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (441 aa)
OHU30788.1HNH endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (110 aa)
OHU31415.1Rossman fold protein, TIGR00730 family; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LOG family. (188 aa)
fas6_1Rossman fold protein, TIGR00730 family; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LOG family. (250 aa)
OHU30809.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa)
OHU31033.1Isochorismatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
OHU31102.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (453 aa)
OHU31149.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the major facilitator superfamily. (470 aa)
OHU31486.1Resuscitation-promoting factor RpfA; Derived by automated computational analysis using gene prediction method: Protein Homology. (366 aa)
OHU31304.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (478 aa)
OHU28951.1HNH endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
pyrDDihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (353 aa)
OHU20969.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)
tgttRNA-guanine(34) transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form [...] (406 aa)
tadAtRNA-specific adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (152 aa)
OHU21222.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0301 (AlgH) family. (208 aa)
OHU21340.1HNH endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
OHU21470.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
OHU21505.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
dcddCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (189 aa)
OHU21701.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (190 aa)
OHU21761.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (578 aa)
OHU21858.1Resuscitation-promoting factor RpfA; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
OHU21876.1Restriction endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
OHU21921.1Ribonucleotide-diphosphate reductase subunit beta; Catalyzes the rate-limiting step in dNTP synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
groSCo-chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (99 aa)
OHU22190.1Cytidine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
OHU22191.1Thymidine phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (213 aa)
OHU22881.1Purine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
OHU22222.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (505 aa)
OHU22225.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (438 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa)
OHU22400.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (437 aa)
nrdIRibonucleotide reductase assembly protein NrdI; Probably involved in ribonucleotide reductase function. (146 aa)
OHU22402.1Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (722 aa)
nrdF2Class 1b ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (324 aa)
OHU22537.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (442 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (156 aa)
OHU18783.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (501 aa)
pyrRBifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (182 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (317 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (433 aa)
OHU18880.1Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (376 aa)
carBCarbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family. (1112 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (282 aa)
OHU18891.1Acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
OHU18892.1Dihydropyrimidinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (568 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa)
OHU19144.1Lectin; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
OHU19179.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
nrdRTranscriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (154 aa)
thyXFAD-dependent thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (250 aa)
Your Current Organism:
Mycobacteroides franklinii
NCBI taxonomy Id: 948102
Other names: ATCC BAA-2149, DSM 45524, M. franklinii, Mycobacterium franklinii, Mycobacterium franklinii Nogueira et al. 2015, Mycobacterium sp. CV02, Mycobacteroides franklinii (Nogueira et al. 2015) Gupta et al. 2018, strain CV002
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