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map-3 map-3 OHU31400.1 OHU31400.1 tig tig OHU30556.1 OHU30556.1 OHU30552.1 OHU30552.1 OHU30528.1 OHU30528.1 OHU30523.1 OHU30523.1 cobD cobD OHU30398.1 OHU30398.1 OHU30393.1 OHU30393.1 OHU30390.1 OHU30390.1 cobS cobS cobT cobT OHU30357.1 OHU30357.1 OHU30348.1 OHU30348.1 OHU30805.1 OHU30805.1 OHU30849.1 OHU30849.1 OHU31052.1 OHU31052.1 OHU28939.1 OHU28939.1 OHU26847.1 OHU26847.1 OHU26848.1 OHU26848.1 OHU26849.1 OHU26849.1 OHU26903.1 OHU26903.1 OHU26850.1 OHU26850.1 OHU26851.1 OHU26851.1 OHU26852.1 OHU26852.1 OHU26853.1 OHU26853.1 OHU22600.1 OHU22600.1 mhuD mhuD OHU20804.1 OHU20804.1 OHU20900.1 OHU20900.1 OHU20901.1 OHU20901.1 OHU20902.1 OHU20902.1 OHU22658.1 OHU22658.1 OHU21099.1 OHU21099.1 OHU21105.1 OHU21105.1 OHU22669.1 OHU22669.1 map map OHU21315.1 OHU21315.1 OHU21354.1 OHU21354.1 OHU21607.1 OHU21607.1 OHU21608.1 OHU21608.1 OHU21726.1 OHU21726.1 hemA hemA hemC hemC OHU21936.1 OHU21936.1 OHU21937.1 OHU21937.1 hemL hemL OHU21954.1 OHU21954.1 OHU22048.1 OHU22048.1 OHU22049.1 OHU22049.1 map-2 map-2 OHU22303.1 OHU22303.1 OHU22304.1 OHU22304.1 OHU22449.1 OHU22449.1 gltX gltX OHU22547.1 OHU22547.1 hemE hemE OHU19341.1 OHU19341.1 OHU18760.1 OHU18760.1 OHU18844.1 OHU18844.1 ctaB ctaB OHU18939.1 OHU18939.1 OHU18941.1 OHU18941.1 OHU18969.1 OHU18969.1 OHU18971.1 OHU18971.1 hemH hemH OHU19050.1 OHU19050.1 OHU19400.1 OHU19400.1 OHU19165.1 OHU19165.1 OHU19316.1 OHU19316.1 OHU18202.1 OHU18202.1 cobB-2 cobB-2 OHU18212.1 OHU18212.1 OHU18213.1 OHU18213.1 cobQ cobQ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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map-3Type I methionyl aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (267 aa)
OHU31400.1ATP:cob(I)alamin adenosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Cob(I)alamin adenosyltransferase family. (191 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (488 aa)
OHU30556.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
OHU30552.1Histidine phosphatase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate mutase family. (221 aa)
OHU30528.1Cobalamin biosynthesis protein CbiX; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
OHU30523.1Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (391 aa)
cobDCobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (314 aa)
OHU30398.1Bifunctional RNase H/acid phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa)
OHU30393.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (320 aa)
OHU30390.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
cobSadenosylcobinamide-GDP ribazoletransferase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (252 aa)
cobTNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (352 aa)
OHU30357.1Adenosylcobinamide kinase/adenosylcobinamide phosphate guanyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
OHU30348.1PPOX class F420-dependent enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (145 aa)
OHU30805.1Monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (102 aa)
OHU30849.1Copper oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (506 aa)
OHU31052.1precorrin-6A synthase (deacetylating); Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
OHU28939.1PPOX class F420-dependent enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (143 aa)
OHU26847.1PPOX class F420-dependent enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (141 aa)
OHU26848.1Cobalamin biosynthesis bifunctional protein CbiET; Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa)
OHU26849.1Precorrin-4 C(11)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
OHU26903.1cobalt-precorrin-6A reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
OHU26850.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the precorrin methyltransferase family. (492 aa)
OHU26851.1precorrin-8X methylmutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
OHU26852.1precorrin-3B synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
OHU26853.1Cobaltochelatase subunit CobN; Derived by automated computational analysis using gene prediction method: Protein Homology. (1211 aa)
OHU22600.1AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
mhuDAntibiotic biosynthesis monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
OHU20804.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (522 aa)
OHU20900.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
OHU20901.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
OHU20902.1AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
OHU22658.1tRNA glutamyl-Q(34) synthetase GluQRS; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
OHU21099.1Histidine phosphatase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
OHU21105.1Bacterioferritin; Iron-storage protein. (185 aa)
OHU22669.1Bacterioferritin; Iron-storage protein. (181 aa)
mapType I methionyl aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (255 aa)
OHU21315.1Biliverdin-producing heme oxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
OHU21354.1DNA starvation/stationary phase protection protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Dps family. (163 aa)
OHU21607.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (375 aa)
OHU21608.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (352 aa)
OHU21726.1F420-dependent protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (131 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (443 aa)
hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (307 aa)
OHU21936.1Bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (549 aa)
OHU21937.1Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. (327 aa)
hemLGlutamate-1-semialdehyde-2,1-aminomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
OHU21954.1Pyridoxamine 5-phosphate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
OHU22048.1Mycofactocin system protein MftB; Derived by automated computational analysis using gene prediction method: Protein Homology. (101 aa)
OHU22049.1Mycofactocin radical SAM maturase; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
map-2Type I methionyl aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (264 aa)
OHU22303.1uroporphyrinogen-III synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
OHU22304.1Cobalamin biosynthesis protein CbiX; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
OHU22449.1SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
gltXglutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (500 aa)
OHU22547.1PPOX class F420-dependent enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (364 aa)
OHU19341.1Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (460 aa)
OHU18760.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
OHU18844.1Glutamate-1-semialdehyde 2,1-aminomutase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (406 aa)
ctaBProtoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (311 aa)
OHU18939.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (110 aa)
OHU18941.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
OHU18969.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
OHU18971.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (340 aa)
OHU19050.1Glutamate-1-semialdehyde 2,1-aminomutase; Catalyzes the formation of 5-aminovulinate from (S)-4-amino-5-oxopentanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa)
OHU19400.1Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
OHU19165.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
OHU19316.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (630 aa)
OHU18202.1uroporphyrinogen-III C-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
cobB-2Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (443 aa)
OHU18212.1cob(I)yrinic acid a,c-diamide adenosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (204 aa)
OHU18213.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (628 aa)
cobQCobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (504 aa)
Your Current Organism:
Mycobacteroides franklinii
NCBI taxonomy Id: 948102
Other names: ATCC BAA-2149, DSM 45524, M. franklinii, Mycobacterium franklinii, Mycobacterium franklinii Nogueira et al. 2015, Mycobacterium sp. CV02, Mycobacteroides franklinii (Nogueira et al. 2015) Gupta et al. 2018, strain CV002
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