(32 nodes) Cholesterol transport network (Tinamus guttatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	N309_04870	Hepatic triacylglycerol lipase. (442 aa)
	N309_08426	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta. (363 aa)
	N309_07683	Niemann-Pick C1 protein. (1259 aa)
	N309_01469	Podocan. (314 aa)
	N309_09861	ATP-binding cassette sub-family G member 4. (642 aa)
	N309_11282	ATP-binding cassette sub-family G member 8. (654 aa)
	N309_10380	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (280 aa)
	N309_12669	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (505 aa)
	N309_02591	Synaptotagmin-7. (600 aa)
	N309_14805	LIM domain and actin-binding protein 1. (740 aa)
	N309_00822	Vacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family. (121 aa)
	N309_13969	Protein ARV1. (235 aa)
	N309_11126	StAR-related lipid transfer protein 4. (207 aa)
	N309_08927	Two pore calcium channel protein 2. (698 aa)
	N309_05576	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1471 aa)
	N309_05068	Vacuolar protein sorting-associated protein 4B. (149 aa)
	N309_08613	Epididymal secretory protein E1. (122 aa)
	N309_07898	MLN64 N-terminal domain. (227 aa)
	N309_00698	Low-density lipoprotein receptor-related protein 6. (1508 aa)
	N309_00419	StAR-related lipid transfer protein 5. (162 aa)
	N309_00294	StAR-related lipid transfer protein 3. (176 aa)
	N309_05695	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha. (358 aa)
	N309_07501	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (555 aa)
	N309_00732	Vacuolar protein sorting-associated protein 4A. (107 aa)
	N309_05067	Vacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (180 aa)
	N309_13207	Low density lipoprotein receptor adapter protein 1. (149 aa)
	N309_05045	Oxysterol-binding protein; Belongs to the OSBP family. (469 aa)
	N309_12164	ATP-binding cassette sub-family G member 1. (579 aa)
	N309_05060	LisH domain and HEAT repeat-containing protein KIAA1468. (1044 aa)
	N309_13154	Uncharacterized protein. (178 aa)
	N309_01619	Apolipoprotein B-100. (4528 aa)
	N309_10701	Xin actin-binding repeat-containing protein 2. (88 aa)

Your Current Organism:

Tinamus guttatus

NCBI taxonomy Id: 94827
Other names: T. guttatus, white-throated tinamou

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N309_00294	N309_00419	A0A099Z377	A0A099Z396	StAR-related lipid transfer protein 3.	StAR-related lipid transfer protein 5.	0.548
N309_00294	N309_07683	A0A099Z377	A0A099YPK4	StAR-related lipid transfer protein 3.	Niemann-Pick C1 protein.	0.402
N309_00294	N309_07898	A0A099Z377	A0A099Z7C0	StAR-related lipid transfer protein 3.	MLN64 N-terminal domain.	0.859
N309_00294	N309_08613	A0A099Z377	A0A099ZDL1	StAR-related lipid transfer protein 3.	Epididymal secretory protein E1.	0.545
N309_00294	N309_10380	A0A099Z377	A0A099ZMR6	StAR-related lipid transfer protein 3.	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.	0.979
N309_00294	N309_11126	A0A099Z377	A0A099YVA5	StAR-related lipid transfer protein 3.	StAR-related lipid transfer protein 4.	0.597
N309_00419	N309_00294	A0A099Z396	A0A099Z377	StAR-related lipid transfer protein 5.	StAR-related lipid transfer protein 3.	0.548
N309_00419	N309_10380	A0A099Z396	A0A099ZMR6	StAR-related lipid transfer protein 5.	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.	0.547
N309_00698	N309_01619	A0A099Z6R5	A0A099ZAE5	Low-density lipoprotein receptor-related protein 6.	Apolipoprotein B-100.	0.595
N309_00698	N309_04870	A0A099Z6R5	A0A099Z7M5	Low-density lipoprotein receptor-related protein 6.	Hepatic triacylglycerol lipase.	0.455
N309_00698	N309_13207	A0A099Z6R5	A0A099Z0D8	Low-density lipoprotein receptor-related protein 6.	Low density lipoprotein receptor adapter protein 1.	0.758
N309_00732	N309_00822	A0A099Z261	A0A099YZN9	Vacuolar protein sorting-associated protein 4A.	Vacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family.	0.899
N309_00732	N309_05067	A0A099Z261	A0A099Z166	Vacuolar protein sorting-associated protein 4A.	Vacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family.	0.928
N309_00822	N309_00732	A0A099YZN9	A0A099Z261	Vacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family.	Vacuolar protein sorting-associated protein 4A.	0.899
N309_00822	N309_05068	A0A099YZN9	A0A099YYL0	Vacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family.	Vacuolar protein sorting-associated protein 4B.	0.899
N309_01619	N309_00698	A0A099ZAE5	A0A099Z6R5	Apolipoprotein B-100.	Low-density lipoprotein receptor-related protein 6.	0.595
N309_01619	N309_04870	A0A099ZAE5	A0A099Z7M5	Apolipoprotein B-100.	Hepatic triacylglycerol lipase.	0.868
N309_01619	N309_05576	A0A099ZAE5	A0A099YZL2	Apolipoprotein B-100.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.622
N309_01619	N309_08613	A0A099ZAE5	A0A099ZDL1	Apolipoprotein B-100.	Epididymal secretory protein E1.	0.705
N309_01619	N309_12669	A0A099ZAE5	A0A099ZMD2	Apolipoprotein B-100.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.822