(13 nodes) Xenobiotics, and Cellular glucuronidation network (Callithrix jacchus)

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Your Input:
	CYP2D19	Cytochrome P450 2D19; Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. (497 aa)
	CYP26B1	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
	CYP2E1	Uncharacterized protein; Belongs to the cytochrome P450 family. (528 aa)
	CYP26C1	Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
	LOC100391186	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
	CYP2C76	Cytochrome P450 2C76; Belongs to the cytochrome P450 family. (489 aa)
	CYP1A2	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (516 aa)
	UGT2A3	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (527 aa)
	CYP2S1	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (503 aa)
	AKR1C1	Aldo-keto reductase family 1 member C1. (323 aa)
	CYP3A21	Cytochrome P450 3A21; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (527 aa)
	CYP2A13	Cytochrome P450 family 2 subfamily A member 13; Belongs to the cytochrome P450 family. (494 aa)
	LOC100414245	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. (551 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKR1C1	CYP2A13	ENSCJAP00000038023	ENSCJAP00000076429	Aldo-keto reductase family 1 member C1.	Cytochrome P450 family 2 subfamily A member 13; Belongs to the cytochrome P450 family.	0.904
AKR1C1	CYP2D19	ENSCJAP00000038023	ENSCJAP00000004200	Aldo-keto reductase family 1 member C1.	Cytochrome P450 2D19; Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes.	0.905
AKR1C1	CYP2E1	ENSCJAP00000038023	ENSCJAP00000008934	Aldo-keto reductase family 1 member C1.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.919
AKR1C1	LOC100391186	ENSCJAP00000038023	ENSCJAP00000018401	Aldo-keto reductase family 1 member C1.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.933
AKR1C1	LOC100414245	ENSCJAP00000038023	ENSCJAP00000078450	Aldo-keto reductase family 1 member C1.	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	0.930
AKR1C1	UGT2A3	ENSCJAP00000038023	ENSCJAP00000034892	Aldo-keto reductase family 1 member C1.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.910
CYP1A2	CYP26B1	ENSCJAP00000032736	ENSCJAP00000006973	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	0.948
CYP1A2	CYP26C1	ENSCJAP00000032736	ENSCJAP00000016129	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family.	0.926
CYP1A2	CYP2A13	ENSCJAP00000032736	ENSCJAP00000076429	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 family 2 subfamily A member 13; Belongs to the cytochrome P450 family.	0.950
CYP1A2	CYP2C76	ENSCJAP00000032736	ENSCJAP00000029395	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 2C76; Belongs to the cytochrome P450 family.	0.937
CYP1A2	CYP2D19	ENSCJAP00000032736	ENSCJAP00000004200	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 2D19; Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes.	0.419
CYP1A2	CYP2E1	ENSCJAP00000032736	ENSCJAP00000008934	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.961
CYP1A2	CYP2S1	ENSCJAP00000032736	ENSCJAP00000037342	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family.	0.931
CYP1A2	CYP3A21	ENSCJAP00000032736	ENSCJAP00000047441	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Cytochrome P450 3A21; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.964
CYP1A2	LOC100391186	ENSCJAP00000032736	ENSCJAP00000018401	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.960
CYP1A2	LOC100414245	ENSCJAP00000032736	ENSCJAP00000078450	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.	0.963
CYP1A2	UGT2A3	ENSCJAP00000032736	ENSCJAP00000034892	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.959
CYP26B1	CYP1A2	ENSCJAP00000006973	ENSCJAP00000032736	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	0.948
CYP26B1	CYP26C1	ENSCJAP00000006973	ENSCJAP00000016129	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family.	0.918
CYP26B1	CYP2C76	ENSCJAP00000006973	ENSCJAP00000029395	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 2C76; Belongs to the cytochrome P450 family.	0.933