STRINGSTRING
RAD54B RAD54B PAXIP1 PAXIP1 RAD52 RAD52 RPA3 RPA3 RAD9A RAD9A RPA1 RPA1 ATR ATR MUS81 MUS81 ATRIP ATRIP TDRD3 TDRD3 MRE11 MRE11 GEN1 GEN1 RAD9B RAD9B SLF1 SLF1 BARD1 BARD1 DMC1 DMC1 WRN WRN BRCA1 BRCA1 RECQL5 RECQL5 EME2 EME2 HUS1 HUS1 MEIOB MEIOB RMI2 RMI2 RAD17 RAD17 XRCC3 XRCC3 EXO1 EXO1 BRCA2 BRCA2 EME1 EME1 DNA2 DNA2 SPO11 SPO11 SLX4 SLX4 TOP3B TOP3B FBH1 FBH1 RAD51 RAD51 RAD54L RAD54L RECQL4 RECQL4 RMI1 RMI1 F7FKC4_CALJA F7FKC4_CALJA FANCM FANCM TP53BP1 TP53BP1 BLM BLM LOC100398346 LOC100398346 TOP3A TOP3A RPA2 RPA2 LOC100385843 LOC100385843 RAD1 RAD1 RAD51B RAD51B RBBP8 RBBP8 ENSCJAP00000063462 ENSCJAP00000063462 XRCC2 XRCC2 RAD51D RAD51D ENSCJAP00000071263 ENSCJAP00000071263 ENSCJAP00000071556 ENSCJAP00000071556 ENSCJAP00000072156 ENSCJAP00000072156 PALB2 PALB2 NBN NBN ENSCJAP00000077268 ENSCJAP00000077268 TOPBP1 TOPBP1 BRIP1 BRIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAD54BUncharacterized protein. (910 aa)
PAXIP1PAX interacting protein 1. (1053 aa)
RAD52RAD52 homolog, DNA repair protein. (419 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (628 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
MUS81MUS81 structure-specific endonuclease subunit. (551 aa)
ATRIPATR-interacting protein isoform 1. (790 aa)
TDRD3Tudor domain containing 3. (744 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (909 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (428 aa)
SLF1Ankyrin repeat domain-containing protein 32. (1059 aa)
BARD1BRCA1 associated RING domain 1. (853 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (339 aa)
WRNWRN RecQ like helicase. (1433 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1830 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (990 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (372 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
MEIOBMeiosis specific with OB-fold. (470 aa)
RMI2Uncharacterized protein. (84 aa)
RAD17Cell cycle checkpoint protein RAD17 isoform 2. (681 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa)
EXO1Exonuclease 1. (852 aa)
BRCA2BRCA2 DNA repair associated. (3409 aa)
EME1Essential meiotic structure-specific endonuclease 1. (584 aa)
DNA2DNA replication helicase/nuclease 2. (987 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (396 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1830 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
FBH1F-box only protein 18 isoform 2. (1045 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
RAD54LDNA repair and recombination protein RAD54-like. (746 aa)
RECQL4RecQ like helicase 4. (1204 aa)
RMI1RecQ-mediated genome instability protein 1. (625 aa)
F7FKC4_CALJAFHA domain-containing protein. (300 aa)
FANCMFA complementation group M. (2043 aa)
TP53BP1Tumor protein p53 binding protein 1. (1971 aa)
BLMBLM RecQ like helicase. (1415 aa)
LOC100398346RAD50 homolog isoform 1 (Predicted). (1312 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
RPA2RPA_C domain-containing protein. (355 aa)
LOC100385843Uncharacterized protein. (147 aa)
RAD1RAD1 checkpoint DNA exonuclease. (283 aa)
RAD51BRAD51 paralog B. (383 aa)
RBBP8RB binding protein 8, endonuclease. (872 aa)
ENSCJAP00000063462RECA_2 domain-containing protein. (204 aa)
XRCC2DNA repair protein XRCC2. (280 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (328 aa)
ENSCJAP00000071263Helicase ATP-binding domain-containing protein. (88 aa)
ENSCJAP00000071556Uncharacterized protein. (70 aa)
ENSCJAP00000072156Uncharacterized protein. (76 aa)
PALB2Partner and localizer of BRCA2. (1182 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (748 aa)
ENSCJAP00000077268Uncharacterized protein. (146 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1563 aa)
BRIP1Uncharacterized protein. (213 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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