STRINGSTRING
PAXIP1 PAXIP1 RAD52 RAD52 RPA3 RPA3 RAD9A RAD9A RPA1 RPA1 ATR ATR ATRIP ATRIP TDRD3 TDRD3 MRE11 MRE11 RAD9B RAD9B SLF1 SLF1 BARD1 BARD1 WRN WRN RECQL5 RECQL5 HUS1 HUS1 MEIOB MEIOB RMI2 RMI2 RAD17 RAD17 EXO1 EXO1 DNA2 DNA2 TOP3B TOP3B RECQL4 RECQL4 RMI1 RMI1 FANCM FANCM TP53BP1 TP53BP1 BLM BLM LOC100398346 LOC100398346 TOP3A TOP3A RPA2 RPA2 LOC100385843 LOC100385843 RAD1 RAD1 NBN NBN TOPBP1 TOPBP1 BRIP1 BRIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAXIP1PAX interacting protein 1. (1053 aa)
RAD52RAD52 homolog, DNA repair protein. (419 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (628 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
ATRIPATR-interacting protein isoform 1. (790 aa)
TDRD3Tudor domain containing 3. (744 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (428 aa)
SLF1Ankyrin repeat domain-containing protein 32. (1059 aa)
BARD1BRCA1 associated RING domain 1. (853 aa)
WRNWRN RecQ like helicase. (1433 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (990 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
MEIOBMeiosis specific with OB-fold. (470 aa)
RMI2Uncharacterized protein. (84 aa)
RAD17Cell cycle checkpoint protein RAD17 isoform 2. (681 aa)
EXO1Exonuclease 1. (852 aa)
DNA2DNA replication helicase/nuclease 2. (987 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
RECQL4RecQ like helicase 4. (1204 aa)
RMI1RecQ-mediated genome instability protein 1. (625 aa)
FANCMFA complementation group M. (2043 aa)
TP53BP1Tumor protein p53 binding protein 1. (1971 aa)
BLMBLM RecQ like helicase. (1415 aa)
LOC100398346RAD50 homolog isoform 1 (Predicted). (1312 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
RPA2RPA_C domain-containing protein. (355 aa)
LOC100385843Uncharacterized protein. (147 aa)
RAD1RAD1 checkpoint DNA exonuclease. (283 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (748 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1563 aa)
BRIP1Uncharacterized protein. (213 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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