(5 nodes) SUMO is conjugated to E1 (UBA2:SAE1), and HLH domain binding network (Callithrix jacchus)

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Your Input:
	SUMO3	Small ubiquitin-related modifier. (103 aa)
	SAE1	SUMO-activating enzyme subunit 1 isoform a. (346 aa)
	UBA2	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (639 aa)
	UBE2I	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	SUMO1	Small ubiquitin-related modifier. (106 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SAE1	SUMO1	ENSCJAP00000021276	ENSCJAP00000062736	SUMO-activating enzyme subunit 1 isoform a.	Small ubiquitin-related modifier.	0.965
SAE1	SUMO3	ENSCJAP00000021276	ENSCJAP00000019420	SUMO-activating enzyme subunit 1 isoform a.	Small ubiquitin-related modifier.	0.963
SAE1	UBA2	ENSCJAP00000021276	ENSCJAP00000051017	SUMO-activating enzyme subunit 1 isoform a.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.998
SAE1	UBE2I	ENSCJAP00000021276	ENSCJAP00000062635	SUMO-activating enzyme subunit 1 isoform a.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.971
SUMO1	SAE1	ENSCJAP00000062736	ENSCJAP00000021276	Small ubiquitin-related modifier.	SUMO-activating enzyme subunit 1 isoform a.	0.965
SUMO1	SUMO3	ENSCJAP00000062736	ENSCJAP00000019420	Small ubiquitin-related modifier.	Small ubiquitin-related modifier.	0.910
SUMO1	UBA2	ENSCJAP00000062736	ENSCJAP00000051017	Small ubiquitin-related modifier.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.940
SUMO1	UBE2I	ENSCJAP00000062736	ENSCJAP00000062635	Small ubiquitin-related modifier.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.987
SUMO3	SAE1	ENSCJAP00000019420	ENSCJAP00000021276	Small ubiquitin-related modifier.	SUMO-activating enzyme subunit 1 isoform a.	0.963
SUMO3	SUMO1	ENSCJAP00000019420	ENSCJAP00000062736	Small ubiquitin-related modifier.	Small ubiquitin-related modifier.	0.910
SUMO3	UBA2	ENSCJAP00000019420	ENSCJAP00000051017	Small ubiquitin-related modifier.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.944
SUMO3	UBE2I	ENSCJAP00000019420	ENSCJAP00000062635	Small ubiquitin-related modifier.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.995
UBA2	SAE1	ENSCJAP00000051017	ENSCJAP00000021276	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	SUMO-activating enzyme subunit 1 isoform a.	0.998
UBA2	SUMO1	ENSCJAP00000051017	ENSCJAP00000062736	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	Small ubiquitin-related modifier.	0.940
UBA2	SUMO3	ENSCJAP00000051017	ENSCJAP00000019420	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	Small ubiquitin-related modifier.	0.944
UBA2	UBE2I	ENSCJAP00000051017	ENSCJAP00000062635	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.994
UBE2I	SAE1	ENSCJAP00000062635	ENSCJAP00000021276	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	SUMO-activating enzyme subunit 1 isoform a.	0.971
UBE2I	SUMO1	ENSCJAP00000062635	ENSCJAP00000062736	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Small ubiquitin-related modifier.	0.987
UBE2I	SUMO3	ENSCJAP00000062635	ENSCJAP00000019420	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Small ubiquitin-related modifier.	0.995
UBE2I	UBA2	ENSCJAP00000062635	ENSCJAP00000051017	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.994