(16 nodes) Telomere maintenance via recombination network (Callithrix jacchus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ERCC1	Uncharacterized protein. (356 aa)
	SMC5	Structural maintenance of chromosomes 5. (1102 aa)
	F6R7Y8_CALJA	Uncharacterized protein; Belongs to the CGI121/TPRKB family. (98 aa)
	F6R7K4_CALJA	Uncharacterized protein; Belongs to the CGI121/TPRKB family. (190 aa)
	SMC6	Structural maintenance of chromosomes 6. (1039 aa)
	TEP1	Telomerase associated protein 1. (2623 aa)
	XRCC4	DNA repair protein XRCC4 isoform 1. (334 aa)
	NSMCE2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (261 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
	XRCC3	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa)
	BRCA2	BRCA2 DNA repair associated. (3409 aa)
	RAD51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
	ENSCJAP00000060185	Uncharacterized protein; Belongs to the CGI121/TPRKB family. (180 aa)
	ENSCJAP00000063462	RECA_2 domain-containing protein. (204 aa)
	ENSCJAP00000071556	Uncharacterized protein. (70 aa)
	ENSCJAP00000072156	Uncharacterized protein. (76 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA2	ENSCJAP00000063462	ENSCJAP00000034250	ENSCJAP00000063462	BRCA2 DNA repair associated.	RECA_2 domain-containing protein.	0.964
BRCA2	ENSCJAP00000071556	ENSCJAP00000034250	ENSCJAP00000071556	BRCA2 DNA repair associated.	Uncharacterized protein.	0.988
BRCA2	ENSCJAP00000072156	ENSCJAP00000034250	ENSCJAP00000072156	BRCA2 DNA repair associated.	Uncharacterized protein.	0.889
BRCA2	ERCC1	ENSCJAP00000034250	ENSCJAP00000076581	BRCA2 DNA repair associated.	Uncharacterized protein.	0.667
BRCA2	ERCC4	ENSCJAP00000034250	ENSCJAP00000029448	BRCA2 DNA repair associated.	ERCC excision repair 4, endonuclease catalytic subunit.	0.695
BRCA2	RAD51	ENSCJAP00000034250	ENSCJAP00000038743	BRCA2 DNA repair associated.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.998
BRCA2	SMC5	ENSCJAP00000034250	ENSCJAP00000002903	BRCA2 DNA repair associated.	Structural maintenance of chromosomes 5.	0.460
BRCA2	SMC6	ENSCJAP00000034250	ENSCJAP00000013636	BRCA2 DNA repair associated.	Structural maintenance of chromosomes 6.	0.442
BRCA2	XRCC3	ENSCJAP00000034250	ENSCJAP00000031596	BRCA2 DNA repair associated.	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	0.972
ENSCJAP00000063462	BRCA2	ENSCJAP00000063462	ENSCJAP00000034250	RECA_2 domain-containing protein.	BRCA2 DNA repair associated.	0.964
ENSCJAP00000063462	ENSCJAP00000071556	ENSCJAP00000063462	ENSCJAP00000071556	RECA_2 domain-containing protein.	Uncharacterized protein.	0.883
ENSCJAP00000063462	ENSCJAP00000072156	ENSCJAP00000063462	ENSCJAP00000072156	RECA_2 domain-containing protein.	Uncharacterized protein.	0.883
ENSCJAP00000063462	ERCC1	ENSCJAP00000063462	ENSCJAP00000076581	RECA_2 domain-containing protein.	Uncharacterized protein.	0.613
ENSCJAP00000063462	ERCC4	ENSCJAP00000063462	ENSCJAP00000029448	RECA_2 domain-containing protein.	ERCC excision repair 4, endonuclease catalytic subunit.	0.828
ENSCJAP00000063462	NSMCE2	ENSCJAP00000063462	ENSCJAP00000023159	RECA_2 domain-containing protein.	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.	0.554
ENSCJAP00000063462	SMC5	ENSCJAP00000063462	ENSCJAP00000002903	RECA_2 domain-containing protein.	Structural maintenance of chromosomes 5.	0.571
ENSCJAP00000063462	SMC6	ENSCJAP00000063462	ENSCJAP00000013636	RECA_2 domain-containing protein.	Structural maintenance of chromosomes 6.	0.714
ENSCJAP00000063462	XRCC3	ENSCJAP00000063462	ENSCJAP00000031596	RECA_2 domain-containing protein.	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	0.943
ENSCJAP00000071556	BRCA2	ENSCJAP00000071556	ENSCJAP00000034250	Uncharacterized protein.	BRCA2 DNA repair associated.	0.988
ENSCJAP00000071556	ENSCJAP00000063462	ENSCJAP00000071556	ENSCJAP00000063462	Uncharacterized protein.	RECA_2 domain-containing protein.	0.883