STRINGSTRING
XRCC3 XRCC3 F7HXM5_CALJA F7HXM5_CALJA SMC5 SMC5 RPA1 RPA1 CCNE1 CCNE1 ATR ATR RIF1 RIF1 F6R7Y8_CALJA F6R7Y8_CALJA F6R7K4_CALJA F6R7K4_CALJA DKC1 DKC1 PIF1 PIF1 RUVBL1 RUVBL1 INO80D INO80D PARP3 PARP3 TINF2 TINF2 INO80E INO80E SMC6 SMC6 ACTR8 ACTR8 UCHL5 UCHL5 TNKS1BP1 TNKS1BP1 APEX1 APEX1 TEP1 TEP1 ATM ATM XRCC4 XRCC4 WRN WRN NSMCE2 NSMCE2 ACTL6A ACTL6A MAD2L2 MAD2L2 TERF2IP TERF2IP TERF1 TERF1 ENSCJAP00000071556 ENSCJAP00000071556 ZNF827 ZNF827 ENSCJAP00000070775 ENSCJAP00000070775 ENSCJAP00000069695 ENSCJAP00000069695 ENSCJAP00000068735 ENSCJAP00000068735 XRCC5 XRCC5 ENSCJAP00000068313 ENSCJAP00000068313 ENSCJAP00000068201 ENSCJAP00000068201 TERT TERT ENSCJAP00000067310 ENSCJAP00000067310 PCNA PCNA ENSCJAP00000064692 ENSCJAP00000064692 NHP2 NHP2 DCLRE1B DCLRE1B STN1 STN1 ENSCJAP00000063462 ENSCJAP00000063462 ZSCAN4 ZSCAN4 ENSCJAP00000061515 ENSCJAP00000061515 RTEL1 RTEL1 C5H20orf196 C5H20orf196 ENSCJAP00000060185 ENSCJAP00000060185 NOP10-2 NOP10-2 ENSCJAP00000058536 ENSCJAP00000058536 SP100 SP100 XRCC6 XRCC6 ENSCJAP00000058369 ENSCJAP00000058369 ENSCJAP00000058353 ENSCJAP00000058353 NOP10 NOP10 ENSCJAP00000056608 ENSCJAP00000056608 ENSCJAP00000056213 ENSCJAP00000056213 ZNF365 ZNF365 NFRKB NFRKB ZBTB48 ZBTB48 LOC100398346 LOC100398346 BLM BLM F7FKC4_CALJA F7FKC4_CALJA H9KXV8_CALJA H9KXV8_CALJA RUVBL2 RUVBL2 RECQL4 RECQL4 MCRS1 MCRS1 RAD51 RAD51 INO80 INO80 RFC1 RFC1 SLX4 SLX4 UPF1 UPF1 DCLRE1A DCLRE1A DNA2 DNA2 F7I3K9_CALJA F7I3K9_CALJA TFPT TFPT BRCA2 BRCA2 POT1 POT1 EXO1 EXO1 ACD ACD ERCC4 ERCC4 TERF2 TERF2 WRAP53 WRAP53 HUS1 HUS1 TELO2 TELO2 CTC1 CTC1 ORAOV1 ORAOV1 CCNE2 CCNE2 F7HDR0_CALJA F7HDR0_CALJA RPA3 RPA3 ERCC1 ERCC1 ENSCJAP00000075769 ENSCJAP00000075769 NBN NBN SMARCAL1 SMARCAL1 ENSCJAP00000075418 ENSCJAP00000075418 PRKDC PRKDC PARP1 PARP1 ENSCJAP00000072156 ENSCJAP00000072156 FBXO4 FBXO4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa)
F7HXM5_CALJAKu domain-containing protein. (345 aa)
SMC5Structural maintenance of chromosomes 5. (1102 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (628 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
RIF1Replication timing regulatory factor 1. (2463 aa)
F6R7Y8_CALJAUncharacterized protein; Belongs to the CGI121/TPRKB family. (98 aa)
F6R7K4_CALJAUncharacterized protein; Belongs to the CGI121/TPRKB family. (190 aa)
DKC1Dyskerin pseudouridine synthase 1. (562 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
INO80DINO80 complex subunit D. (1027 aa)
PARP3Poly [ADP-ribose] polymerase. (563 aa)
TINF2TERF1 interacting nuclear factor 2. (449 aa)
INO80EINO80 complex subunit E. (244 aa)
SMC6Structural maintenance of chromosomes 6. (1039 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (630 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (454 aa)
TNKS1BP1182 kDa tankyrase-1-binding protein. (1731 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
TEP1Telomerase associated protein 1. (2623 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
XRCC4DNA repair protein XRCC4 isoform 1. (334 aa)
WRNWRN RecQ like helicase. (1433 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (261 aa)
ACTL6AActin-like protein 6A isoform 1; Belongs to the actin family. (429 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
TERF2IPTelomeric repeat-binding factor 2-interacting protein 1. (399 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (452 aa)
ENSCJAP00000071556Uncharacterized protein. (70 aa)
ZNF827Zinc finger protein 827. (1351 aa)
ENSCJAP00000070775Ribosomal_L7Ae domain-containing protein. (111 aa)
ENSCJAP00000069695Ku domain-containing protein. (325 aa)
ENSCJAP00000068735SAP domain-containing protein. (555 aa)
XRCC5X-ray repair cross complementing 5. (800 aa)
ENSCJAP00000068313Yae1_N domain-containing protein. (332 aa)
ENSCJAP00000068201Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (964 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (287 aa)
ENSCJAP00000067310annotation not available (225 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ENSCJAP00000064692HORMA domain-containing protein. (211 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
DCLRE1BDNA cross-link repair 1B. (530 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
ENSCJAP00000063462RECA_2 domain-containing protein. (204 aa)
ZSCAN4Zinc finger and SCAN domain-containing protein 4. (433 aa)
ENSCJAP00000061515Uncharacterized protein. (64 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1309 aa)
C5H20orf196Uncharacterized protein. (62 aa)
ENSCJAP00000060185Uncharacterized protein; Belongs to the CGI121/TPRKB family. (180 aa)
NOP10-2H/ACA ribonucleoprotein complex subunit 3. (64 aa)
ENSCJAP00000058536Uncharacterized protein. (331 aa)
SP100SP100 nuclear antigen. (880 aa)
XRCC6X-ray repair cross-complementing protein 6. (609 aa)
ENSCJAP00000058369Cyclin_C domain-containing protein; Belongs to the cyclin family. (358 aa)
ENSCJAP00000058353SAP domain-containing protein. (225 aa)
NOP10H/ACA ribonucleoprotein complex subunit 3. (64 aa)
ENSCJAP00000056608Uncharacterized protein. (64 aa)
ENSCJAP00000056213Uncharacterized protein. (92 aa)
ZNF365Zinc finger protein 365. (436 aa)
NFRKBNuclear factor related to kappaB binding protein. (1311 aa)
ZBTB48Zinc finger and BTB domain-containing protein 48. (685 aa)
LOC100398346RAD50 homolog isoform 1 (Predicted). (1312 aa)
BLMBLM RecQ like helicase. (1415 aa)
F7FKC4_CALJAFHA domain-containing protein. (300 aa)
H9KXV8_CALJARibonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (462 aa)
RECQL4RecQ like helicase 4. (1204 aa)
MCRS1Microspherule protein 1. (475 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
INO80INO80 complex ATPase subunit. (1556 aa)
RFC1Replication factor C subunit 1. (1147 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1830 aa)
UPF1UPF1 RNA helicase and ATPase. (1129 aa)
DCLRE1ADNA cross-link repair 1A. (1046 aa)
DNA2DNA replication helicase/nuclease 2. (987 aa)
F7I3K9_CALJASAP domain-containing protein. (225 aa)
TFPTTCF3 fusion partner. (254 aa)
BRCA2BRCA2 DNA repair associated. (3409 aa)
POT1Protection of telomeres 1. (617 aa)
EXO1Exonuclease 1. (852 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (480 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (535 aa)
WRAP53WD repeat containing antisense to TP53. (549 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
TELO2Telomere maintenance 2. (837 aa)
CTC1CST telomere replication complex component 1. (1217 aa)
ORAOV1Uncharacterized protein. (71 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
F7HDR0_CALJARuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (453 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
ERCC1Uncharacterized protein. (356 aa)
ENSCJAP00000075769Ku domain-containing protein. (323 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (748 aa)
SMARCAL1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (957 aa)
ENSCJAP00000075418G-patch domain-containing protein. (314 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4134 aa)
PARP1Poly [ADP-ribose] polymerase. (1040 aa)
ENSCJAP00000072156Uncharacterized protein. (76 aa)
FBXO4F-box only protein 4 isoform 1. (387 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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