STRINGSTRING
PDCD10 PDCD10 EGR3 EGR3 ENSCJAP00000078739 ENSCJAP00000078739 XDH XDH JUND JUND RGCC RGCC FGF7 FGF7 CYBA CYBA FLT4 FLT4 PROK1 PROK1 BMP2 BMP2 ANG ANG FGFR1 FGFR1 ENSCJAP00000072686 ENSCJAP00000072686 ATOH8 ATOH8 IGF2 IGF2 VEGFA VEGFA F3 F3 AKT1 AKT1 THBS1 THBS1 THBS4 THBS4 ENSCJAP00000070441 ENSCJAP00000070441 ALOX5 ALOX5 BMP4 BMP4 PLXNB3 PLXNB3 APELA APELA ITGA4 ITGA4 NRARP NRARP AGGF1 AGGF1 JUN JUN PDGFB PDGFB SPARC SPARC ATP5IF1 ATP5IF1 FLT1 FLT1 ZNF580 ZNF580 SYNJ2BP SYNJ2BP PRKD2 PRKD2 DLL4 DLL4 MEF2C MEF2C JCAD JCAD ALDH1A2 ALDH1A2 FUT1 FUT1 ENSCJAP00000056700 ENSCJAP00000056700 VASH2 VASH2 FGF10 FGF10 VEGFC VEGFC TNF TNF VEGFD VEGFD PROX1 PROX1 SIRT1 SIRT1 KRIT1 KRIT1 NRP2 NRP2 AGTR1 AGTR1 TNFSF12 TNFSF12 FUT2 FUT2 BMP6 BMP6 VASH1 VASH1 GATA2 GATA2 PGF PGF ENG ENG ITGB3 ITGB3 HIF1A HIF1A IL12B IL12B SP1 SP1 IL10 IL10 TEK TEK KDR KDR VEGFB VEGFB PLCG1 PLCG1 NR4A1 NR4A1 ACVRL1 ACVRL1 LEP LEP LRG1 LRG1 MYDGF MYDGF AKT3 AKT3 CCL24 CCL24 GHRL GHRL CXCL12 CXCL12 AIMP1 AIMP1 PTPRM PTPRM SIRT6 SIRT6 PDPK1 PDPK1 NF1 NF1 NRP1 NRP1 GDF2 GDF2 HTR2B HTR2B APOE APOE COL4A3 COL4A3 VIP VIP NRAS NRAS FGFBP1 FGFBP1 SCG2 SCG2 MDK MDK MMRN2 MMRN2 TGFBR1 TGFBR1 PPP1R16B PPP1R16B DBH DBH SEMA5A SEMA5A LOC100395383 LOC100395383 WNT5A WNT5A ARNT ARNT ECM1 ECM1 ADAM17 ADAM17 PRKD1 PRKD1 PRL PRL STAT1 STAT1 CAV2 CAV2 BMPR2 BMPR2 SULF1 SULF1 TNMD TNMD EGF EGF CNMD CNMD EMC10 EMC10 TIE1 TIE1 RPTOR RPTOR GHSR GHSR CCR3 CCR3 TBC1D31 TBC1D31 HMOX1 HMOX1 PIK3CD PIK3CD STAT5A STAT5A IL12A IL12A STAT3 STAT3 PRKCA PRKCA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDCD10Programmed cell death protein 10. (212 aa)
EGR3Early growth response protein 3 isoform 1. (387 aa)
ENSCJAP00000078739Uncharacterized protein. (176 aa)
XDHXanthine dehydrogenase. (1333 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (318 aa)
RGCCRegulator of cell cycle. (161 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CYBAUncharacterized protein. (223 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1366 aa)
PROK1Prokineticin 1. (105 aa)
BMP2Bone morphogenetic protein 2. (401 aa)
ANGRibonuclease A A1; Belongs to the pancreatic ribonuclease family. (146 aa)
FGFR1Fibroblast growth factor receptor. (885 aa)
ENSCJAP00000072686Uncharacterized protein. (174 aa)
ATOH8Atonal bHLH transcription factor 8. (352 aa)
IGF2Insulin like growth factor 2. (348 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (411 aa)
F3Coagulation factor III, tissue factor. (282 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (459 aa)
THBS1Thrombospondin 1. (1178 aa)
THBS4Uncharacterized protein. (1022 aa)
ENSCJAP00000070441TSP C-terminal domain-containing protein. (199 aa)
ALOX5Arachidonate 5-lipoxygenase. (737 aa)
BMP4Bone morphogenetic protein 4 preproprotein. (408 aa)
PLXNB3Plexin B3. (2035 aa)
APELAUncharacterized protein. (54 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
NRARPNotch-regulated ankyrin repeat-containing protein. (114 aa)
AGGF1Uncharacterized protein. (719 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
ATP5IF1ATPase inhibitor, mitochondrial isoform 1. (106 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
ZNF580Zinc finger protein 580. (172 aa)
SYNJ2BPSynaptojanin-2-binding protein. (145 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (888 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (718 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform 3. (483 aa)
JCADJunctional cadherin 5 associated. (1364 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (365 aa)
ENSCJAP00000056700Uncharacterized protein. (355 aa)
VASH2Vasohibin 2. (373 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (402 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (232 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (356 aa)
PROX1Prospero homeobox protein 1. (737 aa)
SIRT1Sirtuin 1. (753 aa)
KRIT1Krev interaction trapped protein 1 isoform 1. (736 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (387 aa)
TNFSF12TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (263 aa)
FUT2L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (343 aa)
BMP6Bone morphogenetic protein 6. (504 aa)
VASH1Vasohibin-1. (365 aa)
GATA2Endothelial transcription factor GATA-2 isoform 1. (480 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (225 aa)
ENGEndoglin. (655 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
SP1Transcription factor Sp1 isoform a. (784 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
TEKTEK receptor tyrosine kinase. (1074 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
VEGFBVascular endothelial growth factor B isoform VEGFB-186; Belongs to the PDGF/VEGF growth factor family. (207 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (826 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
MYDGFMyeloid derived growth factor. (173 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
GHRLAppetite-regulating hormone isoform 1 preproprotein. (117 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (306 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1501 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform 1. (355 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform 1. (556 aa)
NF1Neurofibromin 1. (2839 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (927 aa)
GDF2Growth differentiation factor 2. (426 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
APOEApolipoprotein E. (320 aa)
COL4A3Collagen type IV alpha 3 chain. (1661 aa)
VIPVIP peptides isoform 1 preproprotein. (170 aa)
NRASGTPase NRas. (189 aa)
FGFBP1Fibroblast growth factor binding protein 1. (234 aa)
SCG2Secretogranin II. (579 aa)
MDKMidkine isoform a. (144 aa)
MMRN2Multimerin 2. (949 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (856 aa)
DBHDopamine beta-hydroxylase. (621 aa)
SEMA5ASemaphorin 5A. (1074 aa)
LOC100395383ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform 1. (789 aa)
ECM1Extracellular matrix protein 1 isoform 1. (544 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17 preproprotein. (824 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
PRLGrowth hormone A1. (227 aa)
STAT1Signal transducer and activator of transcription. (791 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
SULF1Sulfatase 1. (1133 aa)
TNMDTenomodulin. (317 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
CNMDChondromodulin. (402 aa)
EMC10ER membrane protein complex subunit 10. (262 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
GHSRGhrelin receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (371 aa)
TBC1D31TBC1 domain family member 31. (1210 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
STAT5ASignal transducer and activator of transcription. (796 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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