STRINGSTRING
TGFBR2 TGFBR2 BMPR2 BMPR2 EFNA1 EFNA1 TBX5 TBX5 NOTCH1 NOTCH1 CCN1 CCN1 ZFPM1 ZFPM1 TGFB2 TGFB2 ACVR1 ACVR1 MDM4 MDM4 BMPR1A BMPR1A GATA4 GATA4 SLIT3 SLIT3 SMAD6 SMAD6 SMAD4 SMAD4 HEY1 HEY1 OLFM1 OLFM1 ENSCJAP00000065950 ENSCJAP00000065950 SOX4 SOX4 HEY2 HEY2 ENSCJAP00000071558 ENSCJAP00000071558 BMP2 BMP2 HEYL HEYL ENSCJAP00000078049 ENSCJAP00000078049
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
EFNA1Ephrin-A1 isoform a; Belongs to the ephrin family. (205 aa)
TBX5T-box transcription factor TBX5 isoform 1. (518 aa)
NOTCH1Notch receptor 1. (2551 aa)
CCN1Cellular communication network factor 1. (381 aa)
ZFPM1Zinc finger protein, FOG family member 1. (992 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
GATA4GATA binding protein 4. (442 aa)
SLIT3Slit homolog 3 protein isoform 2. (1523 aa)
SMAD6Mothers against decapentaplegic homolog. (498 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
HEY1Hairy/enhancer-of-split related with YRPW motif protein 1 isoform b. (308 aa)
OLFM1Olfactomedin 1. (485 aa)
ENSCJAP00000065950Noelin-1 domain-containing protein. (129 aa)
SOX4Transcription factor SOX. (472 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (338 aa)
ENSCJAP00000071558TGF_BETA_2 domain-containing protein. (151 aa)
BMP2Bone morphogenetic protein 2. (401 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
ENSCJAP00000078049Uncharacterized protein. (161 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.