(34 nodes) Regulation of striated muscle cell apoptotic process network (Callithrix jacchus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSCJAP00000039892	Heat shock transcription factor 1. (557 aa)
	LTK	Tyrosine-protein kinase receptor. (863 aa)
	GATA6	GATA binding protein 6. (592 aa)
	PPP1R10	Protein phosphatase 1 regulatory subunit 10. (925 aa)
	NOL3	Nucleolar protein 3. (220 aa)
	PDPK1	3-phosphoinositide-dependent protein kinase 1 isoform 1. (556 aa)
	MDK	Midkine isoform a. (144 aa)
	KIFAP3	Kinesin associated protein 3. (827 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1481 aa)
	NRG1	Neuregulin 1. (713 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	MYOCD	Myocardin isoform 1. (982 aa)
	F7HBH1_CALJA	Protein kinase domain-containing protein. (285 aa)
	POU4F2	POU domain protein. (408 aa)
	AMBRA1	Uncharacterized protein. (473 aa)
	BNIP3	BCL2 interacting protein 3. (257 aa)
	NKX2-5	NK2 homeobox 5. (324 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	ENSCJAP00000078398	Uncharacterized protein. (78 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (622 aa)
	ENSCJAP00000073684	Uncharacterized protein. (81 aa)
	CAMK2D	Protein kinase domain-containing protein. (608 aa)
	RGL2	Ral guanine nucleotide dissociation stimulator like 2. (779 aa)
	ENSCJAP00000070721	Uncharacterized protein. (84 aa)
	BMP7	Bone morphogenetic protein 7. (430 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (338 aa)
	SIRT4	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
	NUPR1	Nuclear protein 1 isoform b. (82 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (270 aa)
	ENSCJAP00000053016	WD_REPEATS_REGION domain-containing protein. (1298 aa)
	GATA4	GATA binding protein 4. (442 aa)
	SFRP2	Secreted frizzled related protein 2. (538 aa)
	FNDC1	Fibronectin type III domain containing 1. (1880 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	ATG5	ENSCJAP00000003870	ENSCJAP00000011649	Uncharacterized protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.702
AMBRA1	BNIP3	ENSCJAP00000003870	ENSCJAP00000000372	Uncharacterized protein.	BCL2 interacting protein 3.	0.590
ATG5	AMBRA1	ENSCJAP00000011649	ENSCJAP00000003870	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.702
ATG5	BNIP3	ENSCJAP00000011649	ENSCJAP00000000372	Autophagy protein 5; Involved in autophagic vesicle formation.	BCL2 interacting protein 3.	0.685
ATG5	ENSCJAP00000053016	ENSCJAP00000011649	ENSCJAP00000053016	Autophagy protein 5; Involved in autophagic vesicle formation.	WD_REPEATS_REGION domain-containing protein.	0.700
ATG5	SIRT4	ENSCJAP00000011649	ENSCJAP00000062853	Autophagy protein 5; Involved in autophagic vesicle formation.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.445
BMP7	SMAD4	ENSCJAP00000070399	ENSCJAP00000056533	Bone morphogenetic protein 7.	Mothers against decapentaplegic homolog.	0.592
BNIP3	AMBRA1	ENSCJAP00000000372	ENSCJAP00000003870	BCL2 interacting protein 3.	Uncharacterized protein.	0.590
BNIP3	ATG5	ENSCJAP00000000372	ENSCJAP00000011649	BCL2 interacting protein 3.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.685
BNIP3	ENSCJAP00000053016	ENSCJAP00000000372	ENSCJAP00000053016	BCL2 interacting protein 3.	WD_REPEATS_REGION domain-containing protein.	0.533
CAMK2D	ENSCJAP00000039892	ENSCJAP00000071439	ENSCJAP00000039892	Protein kinase domain-containing protein.	Heat shock transcription factor 1.	0.407
ENSCJAP00000039892	CAMK2D	ENSCJAP00000039892	ENSCJAP00000071439	Heat shock transcription factor 1.	Protein kinase domain-containing protein.	0.407
ENSCJAP00000039892	F7HBH1_CALJA	ENSCJAP00000039892	ENSCJAP00000006408	Heat shock transcription factor 1.	Protein kinase domain-containing protein.	0.407
ENSCJAP00000053016	ATG5	ENSCJAP00000053016	ENSCJAP00000011649	WD_REPEATS_REGION domain-containing protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.700
ENSCJAP00000053016	BNIP3	ENSCJAP00000053016	ENSCJAP00000000372	WD_REPEATS_REGION domain-containing protein.	BCL2 interacting protein 3.	0.533
F7HBH1_CALJA	ENSCJAP00000039892	ENSCJAP00000006408	ENSCJAP00000039892	Protein kinase domain-containing protein.	Heat shock transcription factor 1.	0.407
GATA4	HAND2	ENSCJAP00000052123	ENSCJAP00000074938	GATA binding protein 4.	Heart and neural crest derivatives expressed 2.	0.894
GATA4	HEY2	ENSCJAP00000052123	ENSCJAP00000067830	GATA binding protein 4.	Hes related family bHLH transcription factor with YRPW motif 2.	0.468
GATA4	MYOCD	ENSCJAP00000052123	ENSCJAP00000008618	GATA binding protein 4.	Myocardin isoform 1.	0.571
GATA4	NKX2-5	ENSCJAP00000052123	ENSCJAP00000075732	GATA binding protein 4.	NK2 homeobox 5.	0.956