STRINGSTRING
TNF TNF PPP1CC PPP1CC LDLR LDLR DICER1 DICER1 F7GTI5_CALJA F7GTI5_CALJA F7FS90_CALJA F7FS90_CALJA IL6 IL6 GJC2 GJC2 NR2E1 NR2E1 TREM2 TREM2 GPR37L1 GPR37L1 SYNJ1 SYNJ1 ID4 ID4 SLC7A5 SLC7A5 RNF10 RNF10 RNF112 RNF112 IL6ST IL6ST MTOR MTOR SKI SKI HES5 HES5 SOX8 SOX8 MBD1 MBD1 NKX6-1 NKX6-1 TTBK1 TTBK1 DUSP10 DUSP10 LRP2 LRP2 DLX2 DLX2 RB1 RB1 ABCC8 ABCC8 LIN28A LIN28A NKX6-2 NKX6-2 EZH2 EZH2 LIF LIF F6SK74_CALJA F6SK74_CALJA DAAM2 DAAM2 NOTCH1 NOTCH1 MDK MDK SERPINE2 SERPINE2 F7IMV6_CALJA F7IMV6_CALJA TNFRSF1B TNFRSF1B SIRT2 SIRT2 NF1 NF1 MECP2 MECP2 TMEM98 TMEM98 TENM4 TENM4 ZNF488 ZNF488 HDAC2 HDAC2 EGR2 EGR2 SOX10 SOX10 BMP2 BMP2 ENSCJAP00000072238 ENSCJAP00000072238 ENSCJAP00000072111 ENSCJAP00000072111 ASPA ASPA ENSCJAP00000070626 ENSCJAP00000070626 DAG1 DAG1 TSPO TSPO ENSCJAP00000067889 ENSCJAP00000067889 SPINT1 SPINT1 CERS2 CERS2 GFAP GFAP SOX11 SOX11 CLCF1 CLCF1 ENSCJAP00000064549 ENSCJAP00000064549 NTF3 NTF3 LINGO1 LINGO1 ACY3 ACY3 ENSCJAP00000077270 ENSCJAP00000077270 ENSCJAP00000077524 ENSCJAP00000077524 LOC100388273 LOC100388273 HDAC1 HDAC1 IL34 IL34 F7FT97_CALJA F7FT97_CALJA F7F298_CALJA F7F298_CALJA ATOH1 ATOH1 F7I9C7_CALJA F7I9C7_CALJA SHH SHH RHEB RHEB TGFB1 TGFB1 NF2 NF2 F2 F2 GSX2 GSX2 E2F1 E2F1 CTNNB1 CTNNB1 PITX3 PITX3 PTPRZ1 PTPRZ1 LYN LYN PLAG1 PLAG1 PRPF19 PRPF19 IL1B IL1B UFL1 UFL1 LOC100410496 LOC100410496 NR1D1 NR1D1 DLX1 DLX1 NTN1 NTN1 TP73 TP73 OLIG2 OLIG2 MAG MAG PRKCI PRKCI ZNF365 ZNF365 PTN PTN ENSCJAP00000054025 ENSCJAP00000054025 ENSCJAP00000053892 ENSCJAP00000053892 NOG NOG VEGFC VEGFC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (232 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
LDLRLow density lipoprotein receptor. (844 aa)
DICER1Endoribonuclease Dicer isoform 1; Belongs to the helicase family. Dicer subfamily. (1922 aa)
F7GTI5_CALJAUncharacterized protein. (599 aa)
F7FS90_CALJAUncharacterized protein. (314 aa)
IL6Interleukin 6. (212 aa)
GJC2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (439 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (421 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (388 aa)
GPR37L1G protein-coupled receptor 37 like 1. (481 aa)
SYNJ1Synaptojanin 1. (1610 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
SLC7A5Solute carrier family 7 member 5. (328 aa)
RNF10Ring finger protein 10. (816 aa)
RNF112RING finger protein 112. (631 aa)
IL6STInterleukin-6 receptor subunit beta isoform 1. (915 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SKISKI proto-oncogene. (729 aa)
HES5Hes family bHLH transcription factor 5. (162 aa)
SOX8SRY-box transcription factor 8. (538 aa)
MBD1Uncharacterized protein. (692 aa)
NKX6-1NK6 homeobox 1. (366 aa)
TTBK1Tau tubulin kinase 1. (1320 aa)
DUSP10Dual specificity protein phosphatase 10 isoform a; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
LRP2LDL receptor related protein 2. (4656 aa)
DLX2Distal-less homeobox 2. (329 aa)
RB1Retinoblastoma-associated protein. (927 aa)
ABCC8ATP binding cassette subfamily C member 8. (1582 aa)
LIN28ALin-28 homolog A. (209 aa)
NKX6-2NK6 homeobox 2. (278 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
LIFLIF interleukin 6 family cytokine. (241 aa)
F6SK74_CALJAUncharacterized protein. (593 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1126 aa)
NOTCH1Notch receptor 1. (2551 aa)
MDKMidkine isoform a. (144 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
F7IMV6_CALJAUncharacterized protein. (146 aa)
TNFRSF1BTNF receptor superfamily member 1B. (462 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
NF1Neurofibromin 1. (2839 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (497 aa)
TMEM98Transmembrane protein 98. (226 aa)
TENM4Teneurin transmembrane protein 4. (2769 aa)
ZNF488Zinc finger protein 488. (233 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (491 aa)
EGR2Early growth response 2. (486 aa)
SOX10Transcription factor SOX-10. (467 aa)
BMP2Bone morphogenetic protein 2. (401 aa)
ENSCJAP00000072238Homeobox domain-containing protein. (270 aa)
ENSCJAP00000072111PRC2_HTH_1 domain-containing protein. (366 aa)
ASPAAspartoacylase. (313 aa)
ENSCJAP00000070626Uncharacterized protein. (225 aa)
DAG1Dystroglycan preproprotein. (895 aa)
TSPOTranslocator protein. (203 aa)
ENSCJAP00000067889Hist_deacetyl domain-containing protein. (209 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (531 aa)
CERS2Ceramide synthase 2. (380 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (504 aa)
SOX11Transcription factor SOX. (448 aa)
CLCF1Cardiotrophin-like cytokine factor 1 isoform 1. (225 aa)
ENSCJAP00000064549Uncharacterized protein. (118 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (292 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (654 aa)
ACY3Aminoacylase 3. (202 aa)
ENSCJAP00000077270Homeobox domain-containing protein. (263 aa)
ENSCJAP00000077524CSP domain-containing protein. (234 aa)
LOC100388273CCHC-type domain-containing protein. (207 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (540 aa)
IL34Interleukin 34. (242 aa)
F7FT97_CALJAHomeobox domain-containing protein. (286 aa)
F7F298_CALJACSP domain-containing protein. (208 aa)
ATOH1Atonal bHLH transcription factor 1. (354 aa)
F7I9C7_CALJACCHC-type domain-containing protein. (209 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (477 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NF2Merlin isoform 1. (595 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
GSX2GS homeobox 2. (305 aa)
E2F1E2F transcription factor 1. (439 aa)
CTNNB1Catenin beta 1. (774 aa)
PITX3Homeobox protein. (302 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2279 aa)
LYNTyrosine-protein kinase. (491 aa)
PLAG1PLAG1 zinc finger. (500 aa)
PRPF19Pre-mRNA-processing factor 19. (504 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
UFL1UFM1 specific ligase 1. (791 aa)
LOC100410496Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (614 aa)
DLX1Homeobox protein DLX-1 isoform 1. (255 aa)
NTN1Netrin-1. (604 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (635 aa)
OLIG2Oligodendrocyte lineage transcription factor 2 (Predicted). (323 aa)
MAGMyelin associated glycoprotein. (637 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
ZNF365Zinc finger protein 365. (436 aa)
PTNUncharacterized protein. (182 aa)
ENSCJAP00000054025CCHC-type domain-containing protein. (211 aa)
ENSCJAP00000053892BAR domain-containing protein. (420 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (402 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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