STRINGSTRING
TGFBR3 TGFBR3 HGF HGF WNT2 WNT2 CAV2 CAV2 JARID2 JARID2 SMAD1 SMAD1 KPNA1 KPNA1 TBX5 TBX5 NOTCH1 NOTCH1 NDRG4 NDRG4 TGFB2 TGFB2 ARID2 ARID2 TENM4 TENM4 BMP10 BMP10 MEGF10 MEGF10 SHH SHH GATA6 GATA6 PEG10 PEG10 SAV1 SAV1 FOXC2 FOXC2 DIPK2A DIPK2A HEY2 HEY2 RGAG4 RGAG4 ENSCJAP00000071558 ENSCJAP00000071558 FGF9 FGF9 NKX2-5 NKX2-5 RTL1 RTL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFBR3Transforming growth factor beta receptor type 3 isoform a. (851 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (813 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1240 aa)
SMAD1Mothers against decapentaplegic homolog. (469 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (562 aa)
TBX5T-box transcription factor TBX5 isoform 1. (518 aa)
NOTCH1Notch receptor 1. (2551 aa)
NDRG4NDRG family member 4. (391 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ARID2AT-rich interaction domain 2. (1836 aa)
TENM4Teneurin transmembrane protein 4. (2769 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
MEGF10Multiple EGF like domains 10. (1142 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (477 aa)
GATA6GATA binding protein 6. (592 aa)
PEG10CCHC-type domain-containing protein. (783 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
FOXC2Forkhead box C2. (501 aa)
DIPK2ADivergent protein kinase domain 2A. (481 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (338 aa)
RGAG4Retrotransposon gag domain-containing protein 4. (563 aa)
ENSCJAP00000071558TGF_BETA_2 domain-containing protein. (151 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (332 aa)
NKX2-5NK2 homeobox 5. (324 aa)
RTL1Retrotransposon Gag like 1. (1359 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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