(32 nodes) Histone phosphorylation network (Callithrix jacchus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MST1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
	VRK3	VRK serine/threonine kinase 3. (514 aa)
	PKN1	Protein kinase N1. (945 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (574 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	AURKA	Aurora kinase A; Belongs to the protein kinase superfamily. (401 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (552 aa)
	BAZ1B	Bromodomain adjacent to zinc finger domain 1B. (1482 aa)
	RPS6KA5	Ribosomal protein S6 kinase. (802 aa)
	RPS6KA4	Ribosomal protein S6 kinase. (772 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (306 aa)
	HASPIN	Histone H3 associated protein kinase. (791 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
	VRK1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (402 aa)
	HIPK4	Homeodomain interacting protein kinase 4. (616 aa)
	ENSCJAP00000075918	Protein kinase domain-containing protein. (253 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	ENSCJAP00000069470	Protein kinase domain-containing protein. (393 aa)
	ENSCJAP00000064549	Uncharacterized protein. (118 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (345 aa)
	ENSCJAP00000062353	Protein kinase domain-containing protein. (229 aa)
	AURKB	Aurora kinase B; Belongs to the protein kinase superfamily. (345 aa)
	INCENP	Inner centromere protein. (910 aa)
	CDK1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
	AURKC	Aurora kinase C isoform 1; Belongs to the protein kinase superfamily. (309 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	VRK2	Serine/threonine-protein kinase VRK2 isoform 1. (510 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	VPRBP	DDB1 and CUL4 associated factor 1. (1510 aa)
	CCNA2	Cyclin-A2; Belongs to the cyclin family. (432 aa)
	NEK11	NIMA related kinase 11. (643 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	CCNA2	ENSCJAP00000018844	ENSCJAP00000005501	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin-A2; Belongs to the cyclin family.	0.744
ATM	CDK1	ENSCJAP00000018844	ENSCJAP00000060226	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.687
ATM	CDK2	ENSCJAP00000018844	ENSCJAP00000063619	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.802
ATM	ENSCJAP00000062353	ENSCJAP00000018844	ENSCJAP00000062353	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein kinase domain-containing protein.	0.539
ATM	HIPK4	ENSCJAP00000018844	ENSCJAP00000051188	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Homeodomain interacting protein kinase 4.	0.504
ATM	PRKAA1	ENSCJAP00000018844	ENSCJAP00000013705	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Non-specific serine/threonine protein kinase.	0.594
AURKA	AURKB	ENSCJAP00000020758	ENSCJAP00000051311	Aurora kinase A; Belongs to the protein kinase superfamily.	Aurora kinase B; Belongs to the protein kinase superfamily.	0.702
AURKA	AURKC	ENSCJAP00000020758	ENSCJAP00000000030	Aurora kinase A; Belongs to the protein kinase superfamily.	Aurora kinase C isoform 1; Belongs to the protein kinase superfamily.	0.690
AURKA	CCNA2	ENSCJAP00000020758	ENSCJAP00000005501	Aurora kinase A; Belongs to the protein kinase superfamily.	Cyclin-A2; Belongs to the cyclin family.	0.876
AURKA	CDK1	ENSCJAP00000020758	ENSCJAP00000060226	Aurora kinase A; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.844
AURKA	CDK2	ENSCJAP00000020758	ENSCJAP00000063619	Aurora kinase A; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.694
AURKA	ENSCJAP00000062353	ENSCJAP00000020758	ENSCJAP00000062353	Aurora kinase A; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.833
AURKA	HASPIN	ENSCJAP00000020758	ENSCJAP00000041932	Aurora kinase A; Belongs to the protein kinase superfamily.	Histone H3 associated protein kinase.	0.480
AURKA	INCENP	ENSCJAP00000020758	ENSCJAP00000058048	Aurora kinase A; Belongs to the protein kinase superfamily.	Inner centromere protein.	0.965
AURKB	AURKA	ENSCJAP00000051311	ENSCJAP00000020758	Aurora kinase B; Belongs to the protein kinase superfamily.	Aurora kinase A; Belongs to the protein kinase superfamily.	0.702
AURKB	AURKC	ENSCJAP00000051311	ENSCJAP00000000030	Aurora kinase B; Belongs to the protein kinase superfamily.	Aurora kinase C isoform 1; Belongs to the protein kinase superfamily.	0.630
AURKB	CCNA2	ENSCJAP00000051311	ENSCJAP00000005501	Aurora kinase B; Belongs to the protein kinase superfamily.	Cyclin-A2; Belongs to the cyclin family.	0.890
AURKB	CDK1	ENSCJAP00000051311	ENSCJAP00000060226	Aurora kinase B; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.893
AURKB	CDK2	ENSCJAP00000051311	ENSCJAP00000063619	Aurora kinase B; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.643
AURKB	ENSCJAP00000062353	ENSCJAP00000051311	ENSCJAP00000062353	Aurora kinase B; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.892